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Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome

Dravet syndrome (DS) is a catastrophic developmental and epileptic encephalopathy characterized by severe, pharmacoresistant seizures and the highest risk of Sudden Unexpected Death in Epilepsy (SUDEP) of all epilepsy syndromes. Here, we investigated the time course of maturation of neuronal GABAerg...

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Detalles Bibliográficos
Autores principales:	Yuan, Yukun, O’Malley, Heather A., Smaldino, Melissa A., Bouza, Alexandra A., Hull, Jacob M., Isom, Lori L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470170/ https://www.ncbi.nlm.nih.gov/pubmed/30996233 http://dx.doi.org/10.1038/s41598-019-42191-0

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