A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis

Apoptotic death of cells damaged by genotoxic stress requires regulatory input from surrounding tissues. The C. elegans scaffold protein KRI-1, ortholog of mammalian KRIT1/CCM1, permits DNA damage-induced apoptosis of cells in the germline by an unknown cell non-autonomous mechanism. We reveal that...

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Detalles Bibliográficos
Autores principales: Chapman, Eric M., Lant, Benjamin, Ohashi, Yota, Yu, Bin, Schertzberg, Michael, Go, Christopher, Dogra, Deepika, Koskimäki, Janne, Girard, Romuald, Li, Yan, Fraser, Andrew G., Awad, Issam A., Abdelilah-Seyfried, Salim, Gingras, Anne-Claude, Derry, W. Brent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470173/
https://www.ncbi.nlm.nih.gov/pubmed/30996251
http://dx.doi.org/10.1038/s41467-019-09829-z

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