Intracellular Fe(2+) accumulation in endothelial cells and pericytes induces blood-brain barrier dysfunction in secondary brain injury after brain hemorrhage

After intracranial hemorrhage (ICH), iron is released from the hematoma and induces secondary brain injury. However, the detail effect of iron on blood-brain barrier (BBB) function is still unknown. We investigated whether hemoglobin (Hb), ferrous ammonium sulfate (FAS) or hemin which contains iron...

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Detalles Bibliográficos
Autores principales: Imai, Takahiko, Iwata, Sena, Hirayama, Tasuku, Nagasawa, Hideko, Nakamura, Shinsuke, Shimazawa, Masamitsu, Hara, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470176/
https://www.ncbi.nlm.nih.gov/pubmed/30996325
http://dx.doi.org/10.1038/s41598-019-42370-z

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