Cargando…

Novel screening system revealed that intracellular cholesterol trafficking can be a good target for colon cancer prevention

In conventional research methods for cancer prevention, cell proliferation and apoptosis have been intensively targeted rather than the protection of normal or benign tumor cells from malignant transformation. In this study, we aimed to identify candidate colon cancer chemopreventive drugs based on...

Descripción completa

Detalles Bibliográficos
Autores principales:	Miyamoto, Shingo, Narita, Takumi, Komiya, Masami, Fujii, Gen, Hamoya, Takahiro, Nakanishi, Ruri, Tamura, Shuya, Kurokawa, Yurie, Takahashi, Maiko, Mutoh, Michihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470178/ https://www.ncbi.nlm.nih.gov/pubmed/30996256 http://dx.doi.org/10.1038/s41598-019-42363-y

Ejemplares similares

Preventive Effects of Heat-Killed Enterococcus faecalis Strain EC-12 on Mouse Intestinal Tumor Development
por: Miyamoto, Shingo, et al.
Publicado: (2017)

Inhibition of NF-kappaB transcriptional activity enhances fucoxanthinol-induced apoptosis in colorectal cancer cells
por: Tamura, Shuya, et al.
Publicado: (2019)

The Radical Scavenger NZ-419 Suppresses Intestinal Polyp Development in Apc-Mutant Mice
por: Kurokawa, Yurie, et al.
Publicado: (2020)

Activation of NF-E2 p45-related factor-2 transcription and inhibition of intestinal tumor development by AHCC, a standardized extract of cultured Lentinula edodes mycelia
por: Takahashi, Maiko, et al.
Publicado: (2019)

Theracurmin inhibits intestinal polyp development in Apc‐mutant mice by inhibiting inflammation‐related factors
por: Adachi, Saeko, et al.
Publicado: (2020)

Chemopreventive effects of a low-side-effect antibiotic drug, erythromycin, on mouse intestinal tumors
por: Hamoya, Takahiro, et al.
Publicado: (2017)

Impact of Acetazolamide, a Carbonic Anhydrase Inhibitor, on the Development of Intestinal Polyps in Min Mice
por: Noma, Nobuharu, et al.
Publicado: (2017)

Effects of NSAIDs on the risk factors of colorectal cancer: a mini review
por: Hamoya, Takahiro, et al.
Publicado: (2016)

Suppression of intestinal carcinogenesis in Apc-mutant mice by limonin
por: Shimizu, Satomi, et al.
Publicado: (2015)

Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells and modifies intestinal polyp development in Apc(Min/+) mice
por: Shimizu, Satomi, et al.
Publicado: (2014)

Suppressive effects of the NADPH oxidase inhibitor apocynin on intestinal tumorigenesis in obese KK‐A (y) and Apc mutant Min mice
por: Komiya, Masami, et al.
Publicado: (2015)

Irsogladine maleate, a gastric mucosal protectant, suppresses intestinal polyp development in Apc-mutant mice
por: Onuma, Wakana, et al.
Publicado: (2016)

Induction of MYCN-amplified neuroblastoma differentiation through NMYC suppression using PPAR-γ antagonist
por: Nakao-Ise, Yukako, et al.
Publicado: (2023)

Intracellular Cholesterol Trafficking and Impact in Neurodegeneration
por: Arenas, Fabian, et al.
Publicado: (2017)

Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice
por: Ishigamori, Rikako, et al.
Publicado: (2017)

Sodium salicylate and 5-aminosalicylic acid synergistically inhibit the growth of human colon cancer cells and mouse intestinal polyp-derived cells
por: Takakura, Hideki, et al.
Publicado: (2022)

A marine bio-functional lipid, fucoxanthinol, attenuates human colorectal cancer stem-like cell tumorigenicity and sphere formation
por: Terasaki, Masaru, et al.
Publicado: (2017)

Intestinal Peyer’s patches prevent tumorigenesis in Apc(Min/+) mice
por: Fujimoto, Kyoko, et al.
Publicado: (2015)

ABCA13 dysfunction associated with psychiatric disorders causes impaired cholesterol trafficking
por: Nakato, Mitsuhiro, et al.
Publicado: (2020)

Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid
por: McCauliff, Leslie A, et al.
Publicado: (2019)

Importance of sessile serrated lesions in a patient with familial adenomatous polyposis
por: Watanabe, Motoki, et al.
Publicado: (2021)

Cholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and Cancer
por: Lyu, Junfang, et al.
Publicado: (2019)

Changes to cholesterol trafficking in macrophages by Leishmania parasites infection
por: Semini, Geo, et al.
Publicado: (2017)

Loss of spatacsin impairs cholesterol trafficking and calcium homeostasis
por: Boutry, Maxime, et al.
Publicado: (2019)

Involvement of NADPH oxidases in suppression of cyclooxygenase-2 promoter-dependent transcriptional activities by sesamol
por: Shimizu, Satomi, et al.
Publicado: (2015)

Very Long-Term Treatment with a Lactobacillus Probiotic Preparation, Lactobacillus Casei Strain Shirota, Suppresses Weight Loss in the Elderly
por: Ishikawa, Hideki, et al.
Publicado: (2020)

Novel Insights Into Sterol Uptake and Intracellular Cholesterol Trafficking During Eimeria bovis Macromeront Formation
por: Silva, Liliana M. R., et al.
Publicado: (2022)

Human Adenoviruses, Cholesterol Trafficking, and NF-κB Signaling
por: Cianciola, Nicholas L., et al.
Publicado: (2018)

Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation
por: de la Roche, Marianne, et al.
Publicado: (2018)

Imipramine Inhibits Chikungunya Virus Replication in Human Skin Fibroblasts through Interference with Intracellular Cholesterol Trafficking
por: Wichit, Sineewanlaya, et al.
Publicado: (2017)

Late Endosomal Cholesterol Accumulation Leads to Impaired Intra-Endosomal Trafficking
por: Sobo, Komla, et al.
Publicado: (2007)

Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking
por: Lyu, Junfang, et al.
Publicado: (2018)

Investigating the Role of Cholesterol and Lipid Trafficking in Mitotane Resistance in Adrenocortical Carcinoma
por: Warde, Kate, et al.
Publicado: (2021)

Isolation and characterization of Chinese hamster ovary cell mutants defective in intracellular low density lipoprotein-cholesterol trafficking
Publicado: (1990)

Good Cholesterol Gone Bad? HDL and COVID-19
por: Kluck, George E. G., et al.
Publicado: (2021)

Triglyceride/low-density-lipoprotein cholesterol ratio is the most valuable predictor for increased small, dense LDL in type 2 diabetes patients
por: Ouchi, Gen, et al.
Publicado: (2022)

Nutritional Viewpoints on Eggs and Cholesterol
por: Sugano, Michihiro, et al.
Publicado: (2021)

Glycolipid Trafficking in Drosophila Undergoes Pathway Switching in Response to Aberrant Cholesterol Levels
por: Hortsch, Ralf, et al.
Publicado: (2010)

Sphingosine kinases regulate ER contacts with late endocytic organelles and cholesterol trafficking
por: Palladino, Elisa N. D., et al.
Publicado: (2022)

Sterol Carrier Protein-2, a Nonspecific Lipid-Transfer Protein, in Intracellular Cholesterol Trafficking in Testicular Leydig Cells
por: Li, Nancy C., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_hrn12p8v604cth6lt6p8pugagb