Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt

In sickle cell disease (SCD), prolonged capillary transit times, resulting from reduced peripheral blood flow, increase the likelihood of rigid red cells entrapment in the microvasculature, predisposing to vaso-occlusive crisis. Since changes in peripheral flow are mediated by the autonomic nervous...

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Detalles Bibliográficos
Autores principales: Chalacheva, Patjanaporn, Kato, Roberta M., Shah, Payal, Veluswamy, Saranya, Denton, Christopher C., Sunwoo, John, Thuptimdang, Wanwara, Wood, John C., Detterich, Jon A., Coates, Thomas D., Khoo, Michael C. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470196/
https://www.ncbi.nlm.nih.gov/pubmed/31031633
http://dx.doi.org/10.3389/fphys.2019.00381

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