Cargando…

Role of TREK-1 in Health and Disease, Focus on the Central Nervous System

TREK-1 is the most studied background K(2P) channel. Its main role is to control cell excitability and maintain the membrane potential below the threshold of depolarization. TREK-1 is multi-regulated by a variety of physical and chemical stimuli which makes it a very promising and challenging target...

Descripción completa

Detalles Bibliográficos
Autores principales:	Djillani, Alaeddine, Mazella, Jean, Heurteaux, Catherine, Borsotto, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470294/ https://www.ncbi.nlm.nih.gov/pubmed/31031627 http://dx.doi.org/10.3389/fphar.2019.00379

Ejemplares similares

Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity
por: Djillani, Alaeddine, et al.
Publicado: (2017)

The Involvement of Sortilin/NTSR3 in Depression as the Progenitor of Spadin and Its Role in the Membrane Expression of TREK-1
por: Mazella, Jean, et al.
Publicado: (2019)

Altered Trek-1 Function in Sortilin Deficient Mice Results in Decreased Depressive-Like Behavior
por: Moreno, Sébastien, et al.
Publicado: (2018)

Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin
por: Hivelin, Céline, et al.
Publicado: (2016)

Editorial: Sortilin and Sortilin Partners in Physiology and Pathologies
por: Mazella, Jean, et al.
Publicado: (2019)

A Human TREK-1/HEK Cell Line: A Highly Efficient Screening Tool for Drug Development in Neurological Diseases
por: Moha ou Maati, Hamid, et al.
Publicado: (2011)

Fluoxetine Protection in Decompression Sickness in Mice is Enhanced by Blocking TREK-1 Potassium Channel with the “spadin” Antidepressant
por: Vallée, Nicolas, et al.
Publicado: (2016)

Spadin, a Sortilin-Derived Peptide, Targeting Rodent TREK-1 Channels: A New Concept in the Antidepressant Drug Design
por: Mazella, Jean, et al.
Publicado: (2010)

Retroinverso analogs of spadin display increased antidepressant effects
por: Veyssiere, Julie, et al.
Publicado: (2014)

Identification and characterization of two zebrafish Twik related potassium channels, Kcnk2a and Kcnk2b
por: Nasr, Nathalie, et al.
Publicado: (2018)

Increased serum levels of sortilin-derived propeptide after electroconvulsive therapy in treatment-resistant depressed patients
por: Roulot, Morgane, et al.
Publicado: (2018)

The Prostacyclin Analogue, Treprostinil, Used in the Treatment of Pulmonary Arterial Hypertension, is a Potent Antagonist of TREK-1 and TREK-2 Potassium Channels
por: Cunningham, Kevin P., et al.
Publicado: (2021)

Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases
por: Tan, Qingyun, et al.
Publicado: (2021)

2-Aminoethoxydiphenyl borate activates the mechanically gated human KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK), and KCNK 10 (TREK-2)
por: Beltrán, Leopoldo, et al.
Publicado: (2013)

TREK channels in Mechanotransduction: a Focus on the Cardiovascular System
por: Herrera-Pérez, Salvador, et al.
Publicado: (2023)

Spadin Selectively Antagonizes Arachidonic Acid Activation of TREK-1 Channels
por: Ma, Ruolin, et al.
Publicado: (2020)

Antiarrhythmic calcium channel blocker verapamil inhibits trek currents in sympathetic neurons
por: Herrera-Pérez, S., et al.
Publicado: (2022)

Synaptotagmin-7 Enhances Facilitation of Ca(v)2.1 Calcium Channels
por: Djillani, Alaeddine, et al.
Publicado: (2022)

Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels
por: Choveau, Frank S, et al.
Publicado: (2021)

Medicinal Cannabis and Central Nervous System Disorders
por: Ortiz, Yuma T., et al.
Publicado: (2022)

Recent Advances in the Use of Focused Ultrasound for Magnetic Resonance Image-Guided Therapeutic Nanoparticle Delivery to the Central Nervous System
por: Fisher, Delaney G., et al.
Publicado: (2019)

The Pharmacological Action of Kaempferol in Central Nervous System Diseases: A Review
por: Silva dos Santos, Jéssica, et al.
Publicado: (2021)

Neuroprotective Mechanisms of Ginsenoside Rb1 in Central Nervous System Diseases
por: Gong, Liang, et al.
Publicado: (2022)

Regulatory mechanisms of tetramethylpyrazine on central nervous system diseases: A review
por: Liu, Yue, et al.
Publicado: (2022)

The Pioglitazone Trek via Human PPAR Gamma: From Discovery to a Medicine at the FDA and Beyond
por: Devchand, Pallavi R., et al.
Publicado: (2018)

Corrigendum: Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels
por: Choveau, Frank S., et al.
Publicado: (2021)

A Review on Central Nervous System Effects of Gastrodin
por: Liu, Yuan, et al.
Publicado: (2018)

TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells
por: Yarishkin, Oleg, et al.
Publicado: (2018)

The Emerging Role of Extracellular Vesicle Derived From Neurons/Neurogliocytes in Central Nervous System Diseases: Novel Insights Into Ischemic Stroke
por: Li, Fan, et al.
Publicado: (2022)

Axon growth inhibition by RhoA/ROCK in the central nervous system
por: Fujita, Yuki, et al.
Publicado: (2014)

Molecular imaging as a guide for the treatment of central nervous system disorders
por: Kim, Euitae, et al.
Publicado: (2013)

The Case for TAAR1 as a Modulator of Central Nervous System Function
por: Rutigliano, Grazia, et al.
Publicado: (2018)

Editorial: Novel therapeutic approaches to treat neuroinflammation in the central nervous system
por: German, Nadezhda A.
Publicado: (2023)

Trabecular Meshwork TREK-1 Channels Function as Polymodal Integrators of Pressure and pH
por: Yarishkin, Oleg, et al.
Publicado: (2019)

Activation of TREK-1, but Not TREK-2, Channel by Mood Stabilizers
por: Kim, Eun-Jin, et al.
Publicado: (2017)

Presynaptic Release-Regulating mGlu1 Receptors in Central Nervous System
por: Pittaluga, Anna
Publicado: (2016)

Advances and Challenges in Intranasal Delivery of Antipsychotic Agents Targeting the Central Nervous System
por: Pandey, Manisha, et al.
Publicado: (2022)

Editorial: Intranasal Delivery of Central Nervous System Active Drugs: Opportunities and Challenges
por: Rodrigues, Márcio, et al.
Publicado: (2022)

Potential therapeutic effects and pharmacological evidence of sinomenine in central nervous system disorders
por: Hong, Hongxiang, et al.
Publicado: (2022)

Hydrogen Sulfide and Endoplasmic Reticulum Stress: A Potential Therapeutic Target for Central Nervous System Degeneration Diseases
por: Zhong, Huimin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4a5nelf59t9ve540ctgre3u9on