Cargando…

Hypoglycemia-activated Hypothalamic Microglia Impairs Glucose Counterregulatory Responses

Glucose is a major fuel for the central nervous system and hypoglycemia is a significant homeostatic stressor, which elicits counterregulatory reactions. Hypothalamic metabolic- and stress-related neurons initiate these actions, however recruitment of glia in control such adaptive circuit remain unk...

Descripción completa

Detalles Bibliográficos
Autores principales:	Winkler, Zsuzsanna, Kuti, Dániel, Polyák, Ágnes, Juhász, Balázs, Gulyás, Krisztina, Lénárt, Nikolett, Dénes, Ádám, Ferenczi, Szilamér, Kovács, Krisztina J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470310/ https://www.ncbi.nlm.nih.gov/pubmed/30996341 http://dx.doi.org/10.1038/s41598-019-42728-3

Ejemplares similares

Recruitment of Corticotropin-Releasing Hormone (CRH) Neurons in Categorically Distinct Stress Reactions in the Mouse Brain
por: Horváth, Krisztina, et al.
Publicado: (2023)

The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice
por: Kuti, Dániel, et al.
Publicado: (2022)

Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia
por: Diggs-Andrews, Kelly A., et al.
Publicado: (2010)

Thrombocytosis and Effects of IL-6 Knock-Out in a Colitis-Associated Cancer Model
por: Josa, Valeria, et al.
Publicado: (2020)

Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size
por: Dénes, Ádám, et al.
Publicado: (2011)

Oligomannan Prebiotic Attenuates Immunological, Clinical and Behavioral Symptoms in Mouse Model of Inflammatory Bowel Disease
por: Ferenczi, Szilamér, et al.
Publicado: (2016)

Microglia control the spread of neurotropic virus infection via P2Y12 signalling and recruit monocytes through P2Y12-independent mechanisms
por: Fekete, Rebeka, et al.
Publicado: (2018)

A Parabrachial-Hypothalamic Cholecystokinin Neurocircuit Controls Counterregulatory Responses to Hypoglycemia
por: Garfield, Alastair S., et al.
Publicado: (2014)

Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice
por: Tooke, Benjamin P., et al.
Publicado: (2018)

Differential Changes in Expression of Stress- and Metabolic-Related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal
por: Pintér-Kübler, Bernadett, et al.
Publicado: (2013)

Efficient treatment of a preclinical inflammatory bowel disease model with engineered bacteria
por: Ferenczi, Szilamer, et al.
Publicado: (2020)

Effects of Single and Repeated Oral Doses of Ochratoxin A on the Lipid Peroxidation and Antioxidant Defense Systems in Mouse Kidneys
por: Ferenczi, Szilamér, et al.
Publicado: (2020)

Dissociation Between Hormonal Counterregulatory Responses and Cerebral Glucose Metabolism During Hypoglycemia
por: Lee, John J., et al.
Publicado: (2017)

Hypothalamic Orexin-A Neurons Are Involved in the Response of the Brain Stress System to Morphine Withdrawal
por: Laorden, M. Luisa, et al.
Publicado: (2012)

Hypoglycemia during moderate intensity exercise reduces counterregulatory responses to subsequent hypoglycemia
por: Cade, W. Todd, et al.
Publicado: (2016)

The Medial Amygdalar Nucleus: A Novel Glucose-Sensing Region That Modulates the Counterregulatory Response to Hypoglycemia
por: Zhou, Ligang, et al.
Publicado: (2010)

Effects of Intensive Therapy and Antecedent Hypoglycemia on Counterregulatory Responses to Hypoglycemia in Type 2 Diabetes
por: Davis, Stephen N., et al.
Publicado: (2009)

Relationship Between Hypoglycemia Awareness Status on Clarke/Gold Methods and Counterregulatory Response to Hypoglycemia
por: Rubin, Nathan T, et al.
Publicado: (2022)

BAD Modulates Counterregulatory Responses to Hypoglycemia and Protective Glucoprivic Feeding
por: Osundiji, Mayowa A., et al.
Publicado: (2011)

Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia
por: Gaspari, Sevasti, et al.
Publicado: (2023)

Hypothalamic EphA5 Facilitates Counterregulatory Responses: Possible Role for Bidirectional Signaling Leading to Bistability That Enhances Responsiveness to Hypoglycemia
por: Mobbs, Charles V., et al.
Publicado: (2013)

IL-1 Mediates Chronic Stress-Induced Hyperalgesia Accompanied by Microglia and Astroglia Morphological Changes in Pain-Related Brain Regions in Mice
por: Fülöp, Barbara, et al.
Publicado: (2023)

Comparison of Stress-Induced Changes in Adults and Pups: Is Aldosterone the Main Adrenocortical Stress Hormone during the Perinatal Period in Rats?
por: Varga, János, et al.
Publicado: (2013)

A New Ochratoxin A Biodegradation Strategy Using Cupriavidus basilensis Őr16 Strain
por: Ferenczi, Szilamér, et al.
Publicado: (2014)

Ghrelin does not impact the blunted counterregulatory response to recurrent hypoglycemia in mice
por: Shankar, Kripa, et al.
Publicado: (2023)

Small Decrements in Systemic Glucose Provoke Increases in Hypothalamic Blood Flow Prior to the Release of Counterregulatory Hormones
por: Page, Kathleen A., et al.
Publicado: (2009)

Naloxone, but Not Valsartan, Preserves Responses to Hypoglycemia After Antecedent Hypoglycemia: Role of Metabolic Reprogramming in Counterregulatory Failure
por: Poplawski, Michal M., et al.
Publicado: (2011)

Modulation of β-Adrenergic Receptors in the Ventromedial Hypothalamus Influences Counterregulatory Responses to Hypoglycemia
por: Szepietowska, Barbara, et al.
Publicado: (2011)

Impaired hepatic counterregulatory response to insulin-induced hypoglycemia in hepatic denervated pigs
por: Nielsen, Michael Festersen, et al.
Publicado: (2015)

The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner
por: Tóth, Krisztina, et al.
Publicado: (2022)

Neural pathways that control the glucose counterregulatory response
por: Verberne, Anthony J. M., et al.
Publicado: (2014)

Perifornical Hypothalamic Orexin and Serotonin Modulate the Counterregulatory Response to Hypoglycemic and Glucoprivic Stimuli
por: Otlivanchik, Oleg, et al.
Publicado: (2015)

Effects of Antecedent GABA(A) Activation With Alprazolam on Counterregulatory Responses to Hypoglycemia in Healthy Humans
por: Hedrington, Maka S., et al.
Publicado: (2010)

A New Zearalenone Biodegradation Strategy Using Non-Pathogenic Rhodococcus pyridinivorans K408 Strain
por: Kriszt, Rókus, et al.
Publicado: (2012)

Effects of a Selective Serotonin Reuptake Inhibitor, Fluoxetine, on Counterregulatory Responses to Hypoglycemia in Healthy Individuals
por: Briscoe, Vanessa J., et al.
Publicado: (2008)

Lactate-Induced Release of GABA in the Ventromedial Hypothalamus Contributes to Counterregulatory Failure in Recurrent Hypoglycemia and Diabetes
por: Chan, Owen, et al.
Publicado: (2013)

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke
por: Szalay, Gergely, et al.
Publicado: (2016)

Microglia and Drug-Induced Plasticity in Reward-Related Neuronal Circuits
por: Kovács, Krisztina J.
Publicado: (2012)

Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Counterregulatory Responses to Hypoglycemia in Individuals With Type 1 Diabetes
por: Briscoe, Vanessa J., et al.
Publicado: (2008)

Blunted Counterregulatory Hormone Responses to Hypoglycemia in Young Children and Adolescents With Well-Controlled Type 1 Diabetes
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_3vovi72k2g29h80mtapd25pm16