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Children under 10 years of age were more affected by the 2018/19 influenza A(H1N1)pdm09 epidemic in Canada: possible cohort effect following the 2009 influenza pandemic
INTRODUCTION: Findings from the community-based Canadian Sentinel Practitioner Surveillance Network (SPSN) suggest children were more affected by the 2018/19 influenza A(H1N1)pdm09 epidemic. AIM: To compare the age distribution of A(H1N1)pdm09 cases in 2018/19 to prior seasonal influenza epidemics i...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470369/ https://www.ncbi.nlm.nih.gov/pubmed/30994107 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.15.1900104 |
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author | Skowronski, Danuta M Leir, Siobhan De Serres, Gaston Murti, Michelle Dickinson, James A Winter, Anne-Luise Olsha, Romy Croxen, Matthew A Drews, Steven J Charest, Hugues Martineau, Christine Sabaiduc, Suzana Bastien, Nathalie Li, Yan Petric, Martin Jassem, Agatha Krajden, Mel Gubbay, Jonathan B |
author_facet | Skowronski, Danuta M Leir, Siobhan De Serres, Gaston Murti, Michelle Dickinson, James A Winter, Anne-Luise Olsha, Romy Croxen, Matthew A Drews, Steven J Charest, Hugues Martineau, Christine Sabaiduc, Suzana Bastien, Nathalie Li, Yan Petric, Martin Jassem, Agatha Krajden, Mel Gubbay, Jonathan B |
author_sort | Skowronski, Danuta M |
collection | PubMed |
description | INTRODUCTION: Findings from the community-based Canadian Sentinel Practitioner Surveillance Network (SPSN) suggest children were more affected by the 2018/19 influenza A(H1N1)pdm09 epidemic. AIM: To compare the age distribution of A(H1N1)pdm09 cases in 2018/19 to prior seasonal influenza epidemics in Canada. METHODS: The age distribution of unvaccinated influenza A(H1N1)pdm09 cases and test-negative controls were compared across A(H1N1)pdm09-dominant epidemics in 2018/19, 2015/16 and 2013/14 and with the general population of SPSN provinces. Similar comparisons were undertaken for influenza A(H3N2)-dominant epidemics. RESULTS: In 2018/19, more influenza A(H1N1)pdm09 cases were under 10 years old than controls (29% vs 16%; p < 0.001). In particular, children aged 5–9 years comprised 14% of cases, greater than their contribution to controls (4%) or the general population (5%) and at least twice their contribution in 2015/16 (7%; p < 0.001) or 2013/14 (5%; p < 0.001). Conversely, children aged 10–19 years (11% of the population) were under-represented among A(H1N1)pdm09 cases versus controls in 2018/19 (7% vs 12%; p < 0.001), 2015/16 (7% vs 13%; p < 0.001) and 2013/14 (9% vs 12%; p = 0.12). CONCLUSION: Children under 10 years old contributed more to outpatient A(H1N1)pdm09 medical visits in 2018/19 than prior seasonal epidemics in Canada. In 2018/19, all children under 10 years old were born after the 2009 A(H1N1)pdm09 pandemic and therefore lacked pandemic-induced immunity. In addition, more than half those born after 2009 now attend school (i.e. 5–9-year-olds), a socio-behavioural context that may enhance transmission and did not apply during prior A(H1N1)pdm09 epidemics. |
format | Online Article Text |
id | pubmed-6470369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | European Centre for Disease Prevention and Control (ECDC) |
record_format | MEDLINE/PubMed |
spelling | pubmed-64703692019-05-01 Children under 10 years of age were more affected by the 2018/19 influenza A(H1N1)pdm09 epidemic in Canada: possible cohort effect following the 2009 influenza pandemic Skowronski, Danuta M Leir, Siobhan De Serres, Gaston Murti, Michelle Dickinson, James A Winter, Anne-Luise Olsha, Romy Croxen, Matthew A Drews, Steven J Charest, Hugues Martineau, Christine Sabaiduc, Suzana Bastien, Nathalie Li, Yan Petric, Martin Jassem, Agatha Krajden, Mel Gubbay, Jonathan B Euro Surveill Research INTRODUCTION: Findings from the community-based Canadian Sentinel Practitioner Surveillance Network (SPSN) suggest children were more affected by the 2018/19 influenza A(H1N1)pdm09 epidemic. AIM: To compare the age distribution of A(H1N1)pdm09 cases in 2018/19 to prior seasonal influenza epidemics in Canada. METHODS: The age distribution of unvaccinated influenza A(H1N1)pdm09 cases and test-negative controls were compared across A(H1N1)pdm09-dominant epidemics in 2018/19, 2015/16 and 2013/14 and with the general population of SPSN provinces. Similar comparisons were undertaken for influenza A(H3N2)-dominant epidemics. RESULTS: In 2018/19, more influenza A(H1N1)pdm09 cases were under 10 years old than controls (29% vs 16%; p < 0.001). In particular, children aged 5–9 years comprised 14% of cases, greater than their contribution to controls (4%) or the general population (5%) and at least twice their contribution in 2015/16 (7%; p < 0.001) or 2013/14 (5%; p < 0.001). Conversely, children aged 10–19 years (11% of the population) were under-represented among A(H1N1)pdm09 cases versus controls in 2018/19 (7% vs 12%; p < 0.001), 2015/16 (7% vs 13%; p < 0.001) and 2013/14 (9% vs 12%; p = 0.12). CONCLUSION: Children under 10 years old contributed more to outpatient A(H1N1)pdm09 medical visits in 2018/19 than prior seasonal epidemics in Canada. In 2018/19, all children under 10 years old were born after the 2009 A(H1N1)pdm09 pandemic and therefore lacked pandemic-induced immunity. In addition, more than half those born after 2009 now attend school (i.e. 5–9-year-olds), a socio-behavioural context that may enhance transmission and did not apply during prior A(H1N1)pdm09 epidemics. European Centre for Disease Prevention and Control (ECDC) 2019-04-11 /pmc/articles/PMC6470369/ /pubmed/30994107 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.15.1900104 Text en This article is copyright of the authors or their affiliated institutions, 2019. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
spellingShingle | Research Skowronski, Danuta M Leir, Siobhan De Serres, Gaston Murti, Michelle Dickinson, James A Winter, Anne-Luise Olsha, Romy Croxen, Matthew A Drews, Steven J Charest, Hugues Martineau, Christine Sabaiduc, Suzana Bastien, Nathalie Li, Yan Petric, Martin Jassem, Agatha Krajden, Mel Gubbay, Jonathan B Children under 10 years of age were more affected by the 2018/19 influenza A(H1N1)pdm09 epidemic in Canada: possible cohort effect following the 2009 influenza pandemic |
title | Children under 10 years of age were more affected by the 2018/19 influenza A(H1N1)pdm09 epidemic in Canada: possible cohort effect following the 2009 influenza pandemic |
title_full | Children under 10 years of age were more affected by the 2018/19 influenza A(H1N1)pdm09 epidemic in Canada: possible cohort effect following the 2009 influenza pandemic |
title_fullStr | Children under 10 years of age were more affected by the 2018/19 influenza A(H1N1)pdm09 epidemic in Canada: possible cohort effect following the 2009 influenza pandemic |
title_full_unstemmed | Children under 10 years of age were more affected by the 2018/19 influenza A(H1N1)pdm09 epidemic in Canada: possible cohort effect following the 2009 influenza pandemic |
title_short | Children under 10 years of age were more affected by the 2018/19 influenza A(H1N1)pdm09 epidemic in Canada: possible cohort effect following the 2009 influenza pandemic |
title_sort | children under 10 years of age were more affected by the 2018/19 influenza a(h1n1)pdm09 epidemic in canada: possible cohort effect following the 2009 influenza pandemic |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470369/ https://www.ncbi.nlm.nih.gov/pubmed/30994107 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.15.1900104 |
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