Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression

A considerable body of evidence has shown that inflammation plays an important role in the process of stroke rehabilitation and development of poststroke depression (PSD). However, the specific molecular and cellular mechanisms involved remain unclear. In this review, we summarize how neuroinflammat...

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Autores principales: Fang, Meidan, Zhong, Lili, Jin, Xin, Cui, Ranji, Yang, Wei, Gao, Shuohui, Lv, Jing, Li, Bingjin, Liu, Tongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470379/
https://www.ncbi.nlm.nih.gov/pubmed/31031649
http://dx.doi.org/10.3389/fpsyt.2019.00184
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author Fang, Meidan
Zhong, Lili
Jin, Xin
Cui, Ranji
Yang, Wei
Gao, Shuohui
Lv, Jing
Li, Bingjin
Liu, Tongjun
author_facet Fang, Meidan
Zhong, Lili
Jin, Xin
Cui, Ranji
Yang, Wei
Gao, Shuohui
Lv, Jing
Li, Bingjin
Liu, Tongjun
author_sort Fang, Meidan
collection PubMed
description A considerable body of evidence has shown that inflammation plays an important role in the process of stroke rehabilitation and development of poststroke depression (PSD). However, the specific molecular and cellular mechanisms involved remain unclear. In this review, we summarize how neuroinflammation affects stroke rehabilitation and PSD. We mainly focus on the immune/inflammatory response, involving astrocytes, microglia, monocyte-derived macrophages, cytokines (tumor necrosis factor alpha, interleukin 1), and microRNAs (microRNA-124, microRNA 133b). This review provides new insights into the effect of inflammation on the process of stroke rehabilitation and PSD and potentially offer new therapeutic targets of stroke and PSD.
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spelling pubmed-64703792019-04-26 Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression Fang, Meidan Zhong, Lili Jin, Xin Cui, Ranji Yang, Wei Gao, Shuohui Lv, Jing Li, Bingjin Liu, Tongjun Front Psychiatry Psychiatry A considerable body of evidence has shown that inflammation plays an important role in the process of stroke rehabilitation and development of poststroke depression (PSD). However, the specific molecular and cellular mechanisms involved remain unclear. In this review, we summarize how neuroinflammation affects stroke rehabilitation and PSD. We mainly focus on the immune/inflammatory response, involving astrocytes, microglia, monocyte-derived macrophages, cytokines (tumor necrosis factor alpha, interleukin 1), and microRNAs (microRNA-124, microRNA 133b). This review provides new insights into the effect of inflammation on the process of stroke rehabilitation and PSD and potentially offer new therapeutic targets of stroke and PSD. Frontiers Media S.A. 2019-04-11 /pmc/articles/PMC6470379/ /pubmed/31031649 http://dx.doi.org/10.3389/fpsyt.2019.00184 Text en Copyright © 2019 Fang, Zhong, Jin, Cui, Yang, Gao, Lv, Li and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Fang, Meidan
Zhong, Lili
Jin, Xin
Cui, Ranji
Yang, Wei
Gao, Shuohui
Lv, Jing
Li, Bingjin
Liu, Tongjun
Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
title Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
title_full Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
title_fullStr Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
title_full_unstemmed Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
title_short Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
title_sort effect of inflammation on the process of stroke rehabilitation and poststroke depression
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470379/
https://www.ncbi.nlm.nih.gov/pubmed/31031649
http://dx.doi.org/10.3389/fpsyt.2019.00184
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