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PPARδ: A Potential Therapeutic Target for the Treatment of Metabolic Hypertension
High blood pressure and its associated cardiovascular diseases have been major risks for public health. Multiple metabolic risk factors can cause the vascular dysfunction and vascular lesion, and the hypertension due to metabolic disturbances was defined as metabolic hypertension. The members of a s...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470447/ https://www.ncbi.nlm.nih.gov/pubmed/31073415 http://dx.doi.org/10.1155/2019/7809216 |
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author | Jiang, Yanli Li, Qiang Jia, Mengxiao Yan, Zhencheng |
author_facet | Jiang, Yanli Li, Qiang Jia, Mengxiao Yan, Zhencheng |
author_sort | Jiang, Yanli |
collection | PubMed |
description | High blood pressure and its associated cardiovascular diseases have been major risks for public health. Multiple metabolic risk factors can cause the vascular dysfunction and vascular lesion, and the hypertension due to metabolic disturbances was defined as metabolic hypertension. The members of a subfamily of the nuclear receptors, peroxisome proliferator-activated receptors (PPARs), were found to be key regulators of metabolism and vascular function. We provide up-to-date knowledge on the role of subtype PPARδ in the regulation of metabolism and vascular function and the effect of its intervention on the metabolic hypertension management. We hope to give some insights into the development of more effective treatments of metabolic hypertension and its main complications. |
format | Online Article Text |
id | pubmed-6470447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-64704472019-05-09 PPARδ: A Potential Therapeutic Target for the Treatment of Metabolic Hypertension Jiang, Yanli Li, Qiang Jia, Mengxiao Yan, Zhencheng Int J Hypertens Review Article High blood pressure and its associated cardiovascular diseases have been major risks for public health. Multiple metabolic risk factors can cause the vascular dysfunction and vascular lesion, and the hypertension due to metabolic disturbances was defined as metabolic hypertension. The members of a subfamily of the nuclear receptors, peroxisome proliferator-activated receptors (PPARs), were found to be key regulators of metabolism and vascular function. We provide up-to-date knowledge on the role of subtype PPARδ in the regulation of metabolism and vascular function and the effect of its intervention on the metabolic hypertension management. We hope to give some insights into the development of more effective treatments of metabolic hypertension and its main complications. Hindawi 2019-04-03 /pmc/articles/PMC6470447/ /pubmed/31073415 http://dx.doi.org/10.1155/2019/7809216 Text en Copyright © 2019 Yanli Jiang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Jiang, Yanli Li, Qiang Jia, Mengxiao Yan, Zhencheng PPARδ: A Potential Therapeutic Target for the Treatment of Metabolic Hypertension |
title | PPARδ: A Potential Therapeutic Target for the Treatment of Metabolic Hypertension |
title_full | PPARδ: A Potential Therapeutic Target for the Treatment of Metabolic Hypertension |
title_fullStr | PPARδ: A Potential Therapeutic Target for the Treatment of Metabolic Hypertension |
title_full_unstemmed | PPARδ: A Potential Therapeutic Target for the Treatment of Metabolic Hypertension |
title_short | PPARδ: A Potential Therapeutic Target for the Treatment of Metabolic Hypertension |
title_sort | pparδ: a potential therapeutic target for the treatment of metabolic hypertension |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470447/ https://www.ncbi.nlm.nih.gov/pubmed/31073415 http://dx.doi.org/10.1155/2019/7809216 |
work_keys_str_mv | AT jiangyanli ppardapotentialtherapeutictargetforthetreatmentofmetabolichypertension AT liqiang ppardapotentialtherapeutictargetforthetreatmentofmetabolichypertension AT jiamengxiao ppardapotentialtherapeutictargetforthetreatmentofmetabolichypertension AT yanzhencheng ppardapotentialtherapeutictargetforthetreatmentofmetabolichypertension |