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Synthesis and Biological Evaluation of Fangchinoline Derivatives as Anti-Inflammatory Agents through Inactivation of Inflammasome

Twenty eight 7-substitued fangchinoline analogues, of which twenty two were novel, were synthesized and evaluated for their effect to inhibit lipopolysaccharide/nigericin (LPS/NIG)-induced IL-1β release at both cell and protein levels at the concentration of 5 μM. Among them, compound 6 exhibited pr...

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Detalles Bibliográficos
Autores principales:	Liu, Ting, Zeng, Qingxuan, Zhao, Xiaoqiang, Wei, Wei, Li, Yinghong, Deng, Hongbin, Song, Danqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470529/ https://www.ncbi.nlm.nih.gov/pubmed/30909541 http://dx.doi.org/10.3390/molecules24061154

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