One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells

Epirubicin-capped silver nanoparticles (NPs) were synthesized through a one-pot method by using epirubicin as both the functional drug and the reducing agent of Ag(+) to Ag(0). The preparation process was accomplished in 1 h. In addition, the obtained epirubicin-capped silver nanoparticle was charac...

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Detalles Bibliográficos
Autores principales: Ding, Jun, Chen, Guilin, Chen, Guofang, Guo, Mingquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470558/
https://www.ncbi.nlm.nih.gov/pubmed/30884757
http://dx.doi.org/10.3390/pharmaceutics11030123
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author Ding, Jun
Chen, Guilin
Chen, Guofang
Guo, Mingquan
author_facet Ding, Jun
Chen, Guilin
Chen, Guofang
Guo, Mingquan
author_sort Ding, Jun
collection PubMed
description Epirubicin-capped silver nanoparticles (NPs) were synthesized through a one-pot method by using epirubicin as both the functional drug and the reducing agent of Ag(+) to Ag(0). The preparation process was accomplished in 1 h. In addition, the obtained epirubicin-capped silver nanoparticle was characterized by transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and infrared spectroscopy. The results showed that a layer of polymer epirubicin had formed around the silver nanoparticle, which was 30-40 nm in diameter. We further investigated the antitumor activity of the prepared epirubicin-capped silver nanoparticle, and the half maximal inhibitory concentration (IC(50)) against Hep G2 cells was 1.92 μg/mL, indicating a good antitumor property of the nanoparticle at low dosage.
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spelling pubmed-64705582019-04-27 One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells Ding, Jun Chen, Guilin Chen, Guofang Guo, Mingquan Pharmaceutics Article Epirubicin-capped silver nanoparticles (NPs) were synthesized through a one-pot method by using epirubicin as both the functional drug and the reducing agent of Ag(+) to Ag(0). The preparation process was accomplished in 1 h. In addition, the obtained epirubicin-capped silver nanoparticle was characterized by transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and infrared spectroscopy. The results showed that a layer of polymer epirubicin had formed around the silver nanoparticle, which was 30-40 nm in diameter. We further investigated the antitumor activity of the prepared epirubicin-capped silver nanoparticle, and the half maximal inhibitory concentration (IC(50)) against Hep G2 cells was 1.92 μg/mL, indicating a good antitumor property of the nanoparticle at low dosage. MDPI 2019-03-15 /pmc/articles/PMC6470558/ /pubmed/30884757 http://dx.doi.org/10.3390/pharmaceutics11030123 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ding, Jun
Chen, Guilin
Chen, Guofang
Guo, Mingquan
One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells
title One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells
title_full One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells
title_fullStr One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells
title_full_unstemmed One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells
title_short One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells
title_sort one-pot synthesis of epirubicin-capped silver nanoparticles and their anticancer activity against hep g2 cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470558/
https://www.ncbi.nlm.nih.gov/pubmed/30884757
http://dx.doi.org/10.3390/pharmaceutics11030123
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