FcRn-Dependent Transcytosis of Monoclonal Antibody in Human Nasal Epithelial Cells In Vitro: A Prerequisite for a New Delivery Route for Therapy?

Monoclonal antibodies (mAbs) are promising therapies to treat airway chronic inflammatory disease (asthma or nasal polyps). To date, no study has specifically assessed, in vitro, the potential function of neonatal Fc receptor (FcRn) in IgG transcytosis through the human nasal airway epithelium. The...

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Detalles Bibliográficos
Autores principales: Bequignon, Emilie, Dhommée, Christine, Angely, Christelle, Thomas, Lucie, Bottier, Mathieu, Escudier, Estelle, Isabey, Daniel, Coste, André, Louis, Bruno, Papon, Jean-François, Gouilleux-Gruart, Valérie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470570/
https://www.ncbi.nlm.nih.gov/pubmed/30893823
http://dx.doi.org/10.3390/ijms20061379

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