Base-Promoted S(N)Ar Reactions of Fluoro- and Chloroarenes as a Route to N-Aryl Indoles and Carbazoles

KOH/DMSO-promoted C-N bond formation via nucleophilic aromatic substitution (S(N)Ar) between chloroarenes or fluoroarenes with indoles and carbazole under transition metal-free conditions affording the corresponding N-arylated indoles and carbazoles has been developed.

Detalles Bibliográficos
Autores principales: Iqbal, Muhammad Asif, Mehmood, Hina, Lv, Jiaying, Hua, Ruimao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470585/
https://www.ncbi.nlm.nih.gov/pubmed/30909464
http://dx.doi.org/10.3390/molecules24061145
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author Iqbal, Muhammad Asif
Mehmood, Hina
Lv, Jiaying
Hua, Ruimao
author_facet Iqbal, Muhammad Asif
Mehmood, Hina
Lv, Jiaying
Hua, Ruimao
author_sort Iqbal, Muhammad Asif
collection PubMed
description KOH/DMSO-promoted C-N bond formation via nucleophilic aromatic substitution (S(N)Ar) between chloroarenes or fluoroarenes with indoles and carbazole under transition metal-free conditions affording the corresponding N-arylated indoles and carbazoles has been developed.
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spelling pubmed-64705852019-04-26 Base-Promoted S(N)Ar Reactions of Fluoro- and Chloroarenes as a Route to N-Aryl Indoles and Carbazoles Iqbal, Muhammad Asif Mehmood, Hina Lv, Jiaying Hua, Ruimao Molecules Article KOH/DMSO-promoted C-N bond formation via nucleophilic aromatic substitution (S(N)Ar) between chloroarenes or fluoroarenes with indoles and carbazole under transition metal-free conditions affording the corresponding N-arylated indoles and carbazoles has been developed. MDPI 2019-03-22 /pmc/articles/PMC6470585/ /pubmed/30909464 http://dx.doi.org/10.3390/molecules24061145 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Iqbal, Muhammad Asif
Mehmood, Hina
Lv, Jiaying
Hua, Ruimao
Base-Promoted S(N)Ar Reactions of Fluoro- and Chloroarenes as a Route to N-Aryl Indoles and Carbazoles
title Base-Promoted S(N)Ar Reactions of Fluoro- and Chloroarenes as a Route to N-Aryl Indoles and Carbazoles
title_full Base-Promoted S(N)Ar Reactions of Fluoro- and Chloroarenes as a Route to N-Aryl Indoles and Carbazoles
title_fullStr Base-Promoted S(N)Ar Reactions of Fluoro- and Chloroarenes as a Route to N-Aryl Indoles and Carbazoles
title_full_unstemmed Base-Promoted S(N)Ar Reactions of Fluoro- and Chloroarenes as a Route to N-Aryl Indoles and Carbazoles
title_short Base-Promoted S(N)Ar Reactions of Fluoro- and Chloroarenes as a Route to N-Aryl Indoles and Carbazoles
title_sort base-promoted s(n)ar reactions of fluoro- and chloroarenes as a route to n-aryl indoles and carbazoles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470585/
https://www.ncbi.nlm.nih.gov/pubmed/30909464
http://dx.doi.org/10.3390/molecules24061145
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