Cargando…

Base-Promoted S(N)Ar Reactions of Fluoro- and Chloroarenes as a Route to N-Aryl Indoles and Carbazoles

KOH/DMSO-promoted C-N bond formation via nucleophilic aromatic substitution (S(N)Ar) between chloroarenes or fluoroarenes with indoles and carbazole under transition metal-free conditions affording the corresponding N-arylated indoles and carbazoles has been developed.

Detalles Bibliográficos
Autores principales:	Iqbal, Muhammad Asif, Mehmood, Hina, Lv, Jiaying, Hua, Ruimao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470585/ https://www.ncbi.nlm.nih.gov/pubmed/30909464 http://dx.doi.org/10.3390/molecules24061145

Ejemplares similares

Quinazolinone Synthesis through Base-Promoted S(N)Ar Reaction of ortho-Fluorobenzamides with Amides Followed by Cyclization
por: Iqbal, Muhammad Asif, et al.
Publicado: (2019)

Biaryl Formation via Base-Promoted Direct Coupling Reactions of Arenes with Aryl Halides
por: Iqbal, Muhammad Asif, et al.
Publicado: (2021)

Synthesis of Alkyl Aryl Sulfones via Reaction of N-Arylsulfonyl Hydroxyamines with Electron-Deficient Alkenes
por: Bin, Yunhui, et al.
Publicado: (2016)

Recent Progress Concerning the N-Arylation of Indoles
por: Oeser, Petr, et al.
Publicado: (2021)

Direct asymmetric N-propargylation of indoles and carbazoles catalyzed by lithium SPINOL phosphate
por: Wang, Yingcheng, et al.
Publicado: (2020)

Synthesis and Characterization ofTriphenylphosphine Adducts of Ferrocene-Based Palladacycles and Their Performance in the Suzuki and Sonogashira Reactions with Bromo- and Chloroarenes
por: Bai, Su-Zhen, et al.
Publicado: (2012)

Base-Promoted Annulation of Amidoximes with Alkynes: Simple Access to 2,4-Disubstituted Imidazoles
por: Mehmood, Hina, et al.
Publicado: (2020)

Palladium-catalyzed synthesis of N-arylated carbazoles using anilines and cyclic diaryliodonium salts
por: Riedmüller, Stefan, et al.
Publicado: (2013)

Computational exploration of the reaction mechanism of the Cu(+)-catalysed synthesis of indoles from N-aryl enaminones
por: Bernardo, Carlos E. P., et al.
Publicado: (2016)

Base-Promoted One-Pot Synthesis of Pyridine Derivatives via Aromatic Alkyne Annulation Using Benzamides as Nitrogen Source
por: Mehmood, Hina, et al.
Publicado: (2021)

Cascade trifluoromethylthiolation and cyclization of N-[(3-aryl)propioloyl]indoles
por: Bi, Ming-Xi, et al.
Publicado: (2020)

4-Fluoro-N-methyl-N-(1,2,3,4-tetrahydrocarbazol-3-yl)benzenesulfonamide
por: Rasmussen, Kaspar Gothardt, et al.
Publicado: (2009)

Determination of $^{44}Ar$(n,$\gamma$)$^{45}$Ar, and $^{46}$Ar(n,$\gamma$)$^{47}$Ar reaction rates by (d,p) transfer reactions
por: Sorlin, O, et al.
Publicado: (2002)

Catalytic α-Arylation of Imines Leading to N-Unprotected Indoles and Azaindoles
por: Marelli, Enrico, et al.
Publicado: (2016)

Straightforward synthesis of N-arylindoles via one-pot Fischer indolisation–indole N-arylation
por: Lintott, Mia, et al.
Publicado: (2023)

Important Role of NH-Carbazole in Aryl Amination Reactions Catalyzed by 2-Aminobiphenyl Palladacycles
por: Rama, Raquel J., et al.
Publicado: (2023)

Crystal structures of three N-(arylsulfonyl)-4-fluorobenzamides
por: Suchetan, P. A., et al.
Publicado: (2016)

Cobalt-Catalyzed Methoxycarbonylation of Substituted Dichlorobenzenes as an Example of a Facile Radical Anion Nucleophilic Substitution in Chloroarenes
por: Khaibulova, Tatyana S., et al.
Publicado: (2014)

Domino Aza-Michael-S(N)Ar-Heteroaromatization Route to C5-Substituted 1-Alkyl-1H-Indole-3-Carboxylic Esters
por: Ametsetor, Ebenezer, et al.
Publicado: (2022)

Crystal structure and Hirshfeld surface analysis of N-(2-chlorophenylcarbamothioyl)-4-fluorobenzamide and N-(4-bromophenylcarbamothioyl)-4-fluorobenzamide
por: Akhter, Sidra, et al.
Publicado: (2019)

2,6-Difluoro-N-(prop-2-ynyl)benzamide
por: Hussain, Zahid, et al.
Publicado: (2013)

Facile route for N(1)-aryl benzotriazoles from diazoamino arynes via CuI-mediated intramolecular N-arylation
por: Kale, Raju R., et al.
Publicado: (2010)

Asymmetric synthesis of N-allylic indoles via regio- and enantioselective allylation of aryl hydrazines
por: Xu, Kun, et al.
Publicado: (2015)

Investigation of the $^{37}$Ar(n , p) $^{37}\!$Cl, $^{37}$Ar(n , $\alpha)^{34}\!$S and $^{39}$Ar(n , $\alpha) ^{36}$S reactions at various stellar temperatures
por: Goeminne, G, et al.
Publicado: (2001)

Synthesis of Meso-Diarylaminocorroles via S(N)Ar Reactions
por: Ueta, Kento, et al.
Publicado: (2019)

Crystal structures of three N-aryl-2,2,2-tribromoacetamides
por: Sreenivasa, S., et al.
Publicado: (2015)

C(sp(3))-Arylation by Conformationally Accelerated Intramolecular Nucleophilic Aromatic Substitution (S(N)Ar)
por: Wales, Steven M., et al.
Publicado: (2022)

Cu(I)/Pd(II)-Catalyzed Intramolecular Hydroamidation and C-H Dehydrogenative Coupling of ortho-Alkynyl-N-arylbenzamides for Access to Isoindolo[2,1-a]Indol-6-Ones
por: Tang, Baoxin, et al.
Publicado: (2022)

N-Cyclohexyl-2-(5-fluoro-1H-indol-3-yl)-2-oxoacetamide
por: Tian, Dan-Li, et al.
Publicado: (2011)

Direct synthesis of aryl-annulated [c]carbazoles by gold(i)-catalysed cascade reaction of azide-diynes and arenes
por: Kawada, Yuiki, et al.
Publicado: (2018)

The Different Outcomes of Electrochemical Copolymerisation: 3-Hexylthiophene with Indole, Carbazole or Fluorene
por: Gebka, Karolina, et al.
Publicado: (2019)

Synthesis and characterization of a series of conducting polymers based on indole and carbazole
por: ERGİNER, Mehmet, et al.
Publicado: (2022)

Kinetics and Reaction Mechanism of Biothiols Involved in S(N)Ar Reactions: An Experimental Study
por: Campodónico, Paola R., et al.
Publicado: (2022)

DMSO–allyl bromide: a mild and efficient reagent for atom economic one-pot N-allylation and bromination of 2°-aryl amines, 2-aryl aminoamides, indoles and 7-aza indoles
por: Smile, Suresh Snoxma, et al.
Publicado: (2022)

Copper/N,N-Dimethylglycine Catalyzed Goldberg Reactions Between Aryl Bromides and Amides, Aryl Iodides and Secondary Acyclic Amides
por: Jiang, Liqin
Publicado: (2014)

An efficient and atom-economical route to N-aryl amino alcohols from primary amines
por: Xiao, Zhen, et al.
Publicado: (2018)

3-Bromo-9-(4-fluorobenzyl)-9H-carbazole
por: Wang, Cheng-Feng
Publicado: (2009)

N-Aryl Lactams by Regioselective Ozonation of N-Aryl Cyclic Amines
por: Saliu, Francesco, et al.
Publicado: (2012)

Autocatalytic Carbonyl Arylation through In Situ Release of Aryl Nucleophiles from N‐Aryl‐N′‐Silyldiazenes
por: Chauvier, Clément, et al.
Publicado: (2020)

Preparation and characterization of a $^{39}Ar$ sample and study of the $^{39}Ar(n_{th},\alpha)^{36}S$ reaction
por: Goeminne, G, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_uvb1irn6nqjiuug2ams2k9hnn1