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Autologous Platelet Concentrates in Treatment of Furcation Defects—A Systematic Review and Meta-Analysis

Background: The aim of this review was to evaluate the adjunctive effect of autologous platelet concentrates (APCs) for the treatment of furcation defects, in terms of scientific quality of the clinical trials and regeneration parameters assessment. Methods: A systematic search was carried out in th...

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Autores principales: Panda, Sourav, Karanxha, Lorena, Goker, Funda, Satpathy, Anurag, Taschieri, Silvio, Francetti, Luca, Chandra Das, Abhaya, Kumar, Manoj, Panda, Sital, Del Fabbro, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470588/
https://www.ncbi.nlm.nih.gov/pubmed/30884920
http://dx.doi.org/10.3390/ijms20061347
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author Panda, Sourav
Karanxha, Lorena
Goker, Funda
Satpathy, Anurag
Taschieri, Silvio
Francetti, Luca
Chandra Das, Abhaya
Kumar, Manoj
Panda, Sital
Del Fabbro, Massimo
author_facet Panda, Sourav
Karanxha, Lorena
Goker, Funda
Satpathy, Anurag
Taschieri, Silvio
Francetti, Luca
Chandra Das, Abhaya
Kumar, Manoj
Panda, Sital
Del Fabbro, Massimo
author_sort Panda, Sourav
collection PubMed
description Background: The aim of this review was to evaluate the adjunctive effect of autologous platelet concentrates (APCs) for the treatment of furcation defects, in terms of scientific quality of the clinical trials and regeneration parameters assessment. Methods: A systematic search was carried out in the electronic databases MEDLINE, SCOPUS, CENTRAL (Cochrane Central Register of Controlled Trials), and EMBASE, together with hand searching of relevant journals. Two independent reviewers screened the articles yielded in the initial search and retrieved the full-text version of potentially eligible studies. Relevant data and outcomes were extracted from the included studies. Risk of bias assessment was also carried out. The outcome variables, relative to baseline and post-operative defect characteristics (probing pocket depth (PPD), horizontal and vertical clinical attachment loss (HCAL, VCAL), horizontal and vertical furcation depth (HFD, VFD) were considered for meta-analysis. Results: Ten randomized trials were included in this review. Only one study was judged at high risk of bias, while seven had a low risk, testifying to the good level of the evidence of this review. The meta-analysis showed a favorable effect regarding all outcome variables, for APCs used in adjunct to open flap debridement (p < 0.001). Regarding APCs in adjunct to bone grafting, a significant advantage was found only for HCAL (p < 0.001, mean difference 0.74, 95% CI 0.54, 0.94). The sub-group analysis showed that both platelet-rich fibrin and platelet-rich plasma in adjunct with open flap debridement, yielded significantly favorable results. No meta-analysis was performed for APCs in combination with guided tissue regeneration (GTR) as only one study was found. Conclusion: For the treatment of furcation defects APCs may be beneficial as an adjunct to open flap debridement alone and bone grafting, while limited evidence of an effect of APCs when used in combination with GTR was found.
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spelling pubmed-64705882019-04-26 Autologous Platelet Concentrates in Treatment of Furcation Defects—A Systematic Review and Meta-Analysis Panda, Sourav Karanxha, Lorena Goker, Funda Satpathy, Anurag Taschieri, Silvio Francetti, Luca Chandra Das, Abhaya Kumar, Manoj Panda, Sital Del Fabbro, Massimo Int J Mol Sci Review Background: The aim of this review was to evaluate the adjunctive effect of autologous platelet concentrates (APCs) for the treatment of furcation defects, in terms of scientific quality of the clinical trials and regeneration parameters assessment. Methods: A systematic search was carried out in the electronic databases MEDLINE, SCOPUS, CENTRAL (Cochrane Central Register of Controlled Trials), and EMBASE, together with hand searching of relevant journals. Two independent reviewers screened the articles yielded in the initial search and retrieved the full-text version of potentially eligible studies. Relevant data and outcomes were extracted from the included studies. Risk of bias assessment was also carried out. The outcome variables, relative to baseline and post-operative defect characteristics (probing pocket depth (PPD), horizontal and vertical clinical attachment loss (HCAL, VCAL), horizontal and vertical furcation depth (HFD, VFD) were considered for meta-analysis. Results: Ten randomized trials were included in this review. Only one study was judged at high risk of bias, while seven had a low risk, testifying to the good level of the evidence of this review. The meta-analysis showed a favorable effect regarding all outcome variables, for APCs used in adjunct to open flap debridement (p < 0.001). Regarding APCs in adjunct to bone grafting, a significant advantage was found only for HCAL (p < 0.001, mean difference 0.74, 95% CI 0.54, 0.94). The sub-group analysis showed that both platelet-rich fibrin and platelet-rich plasma in adjunct with open flap debridement, yielded significantly favorable results. No meta-analysis was performed for APCs in combination with guided tissue regeneration (GTR) as only one study was found. Conclusion: For the treatment of furcation defects APCs may be beneficial as an adjunct to open flap debridement alone and bone grafting, while limited evidence of an effect of APCs when used in combination with GTR was found. MDPI 2019-03-17 /pmc/articles/PMC6470588/ /pubmed/30884920 http://dx.doi.org/10.3390/ijms20061347 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Panda, Sourav
Karanxha, Lorena
Goker, Funda
Satpathy, Anurag
Taschieri, Silvio
Francetti, Luca
Chandra Das, Abhaya
Kumar, Manoj
Panda, Sital
Del Fabbro, Massimo
Autologous Platelet Concentrates in Treatment of Furcation Defects—A Systematic Review and Meta-Analysis
title Autologous Platelet Concentrates in Treatment of Furcation Defects—A Systematic Review and Meta-Analysis
title_full Autologous Platelet Concentrates in Treatment of Furcation Defects—A Systematic Review and Meta-Analysis
title_fullStr Autologous Platelet Concentrates in Treatment of Furcation Defects—A Systematic Review and Meta-Analysis
title_full_unstemmed Autologous Platelet Concentrates in Treatment of Furcation Defects—A Systematic Review and Meta-Analysis
title_short Autologous Platelet Concentrates in Treatment of Furcation Defects—A Systematic Review and Meta-Analysis
title_sort autologous platelet concentrates in treatment of furcation defects—a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470588/
https://www.ncbi.nlm.nih.gov/pubmed/30884920
http://dx.doi.org/10.3390/ijms20061347
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