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Hyaluronic Acid-Modified and TPCA-1-Loaded Gold Nanocages Alleviate Inflammation
Gold nanocages (AuNCs) are biocompatible and porous nanogold particles that have been widely used in biomedical fields. In this study, hyaluronic acid (HA) and peptide- modified gold nanocages (HA-AuNCs/T/P) loaded with 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide (TPCA-1) were...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470612/ https://www.ncbi.nlm.nih.gov/pubmed/30934538 http://dx.doi.org/10.3390/pharmaceutics11030143 |
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author | Zhao, Jingnan |
author_facet | Zhao, Jingnan |
author_sort | Zhao, Jingnan |
collection | PubMed |
description | Gold nanocages (AuNCs) are biocompatible and porous nanogold particles that have been widely used in biomedical fields. In this study, hyaluronic acid (HA) and peptide- modified gold nanocages (HA-AuNCs/T/P) loaded with 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide (TPCA-1) were prepared to investigate their potential for combating inflammation. TPCA-1 was released from AuNCs, intracellularly when HA was hydrolyzed by hyaluronidase. HA-AuNCs/T/P show a much higher intracellular uptake than AuNCs/T/P, and exhibit a much higher efficacy on the suppression of tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) than free TPCA-1, suggesting great improvement to the anti-inflammatory efficacy of TPCA-1 through the application of AuNCs. HA-AuNCs/T/P can also reduce the production of reactive oxygen species in inflammatory cells. This study suggests that HA-AuNCs/T/P may be potential agents for anti-inflammatory treatment, and are worthy of further investigation. |
format | Online Article Text |
id | pubmed-6470612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64706122019-04-27 Hyaluronic Acid-Modified and TPCA-1-Loaded Gold Nanocages Alleviate Inflammation Zhao, Jingnan Pharmaceutics Communication Gold nanocages (AuNCs) are biocompatible and porous nanogold particles that have been widely used in biomedical fields. In this study, hyaluronic acid (HA) and peptide- modified gold nanocages (HA-AuNCs/T/P) loaded with 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide (TPCA-1) were prepared to investigate their potential for combating inflammation. TPCA-1 was released from AuNCs, intracellularly when HA was hydrolyzed by hyaluronidase. HA-AuNCs/T/P show a much higher intracellular uptake than AuNCs/T/P, and exhibit a much higher efficacy on the suppression of tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) than free TPCA-1, suggesting great improvement to the anti-inflammatory efficacy of TPCA-1 through the application of AuNCs. HA-AuNCs/T/P can also reduce the production of reactive oxygen species in inflammatory cells. This study suggests that HA-AuNCs/T/P may be potential agents for anti-inflammatory treatment, and are worthy of further investigation. MDPI 2019-03-25 /pmc/articles/PMC6470612/ /pubmed/30934538 http://dx.doi.org/10.3390/pharmaceutics11030143 Text en © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Zhao, Jingnan Hyaluronic Acid-Modified and TPCA-1-Loaded Gold Nanocages Alleviate Inflammation |
title | Hyaluronic Acid-Modified and TPCA-1-Loaded Gold Nanocages Alleviate Inflammation |
title_full | Hyaluronic Acid-Modified and TPCA-1-Loaded Gold Nanocages Alleviate Inflammation |
title_fullStr | Hyaluronic Acid-Modified and TPCA-1-Loaded Gold Nanocages Alleviate Inflammation |
title_full_unstemmed | Hyaluronic Acid-Modified and TPCA-1-Loaded Gold Nanocages Alleviate Inflammation |
title_short | Hyaluronic Acid-Modified and TPCA-1-Loaded Gold Nanocages Alleviate Inflammation |
title_sort | hyaluronic acid-modified and tpca-1-loaded gold nanocages alleviate inflammation |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470612/ https://www.ncbi.nlm.nih.gov/pubmed/30934538 http://dx.doi.org/10.3390/pharmaceutics11030143 |
work_keys_str_mv | AT zhaojingnan hyaluronicacidmodifiedandtpca1loadedgoldnanocagesalleviateinflammation |