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Dietary Nutrients Involved in One-Carbon Metabolism and Colonic Mucosa-Associated Gut Microbiome in Individuals with an Endoscopically Normal Colon

One carbon (1C) metabolism nutrients influence epigenetic regulation and they are supplied by diet and synthesized by gut microbiota. We examined the association between dietary consumption of methyl donors (methionine, betaine and choline) and B vitamins (folate, B2, B6, and B12) and the community...

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Autores principales: Gurwara, Shawn, Ajami, Nadim J., Jang, Albert, Hessel, Frances C., Chen, Liang, Plew, Sarah, Wang, Zhensheng, Graham, David Y., Hair, Clark, White, Donna L., Kramer, Jennifer, Kourkoumpetis, Themistoklis, Hoffman, Kristi, Cole, Rhonda, Hou, Jason, Husain, Nisreen, Jarbrink-Sehgal, Maria, Hernaez, Ruben, Kanwal, Fasiha, Ketwaroo, Gyanprakash, Shah, Rajesh, Velez, Maria, Natarajan, Yamini, El-Serag, Hashem B., Petrosino, Joseph F., Jiao, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470629/
https://www.ncbi.nlm.nih.gov/pubmed/30871224
http://dx.doi.org/10.3390/nu11030613
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author Gurwara, Shawn
Ajami, Nadim J.
Jang, Albert
Hessel, Frances C.
Chen, Liang
Plew, Sarah
Wang, Zhensheng
Graham, David Y.
Hair, Clark
White, Donna L.
Kramer, Jennifer
Kourkoumpetis, Themistoklis
Hoffman, Kristi
Cole, Rhonda
Hou, Jason
Husain, Nisreen
Jarbrink-Sehgal, Maria
Hernaez, Ruben
Kanwal, Fasiha
Ketwaroo, Gyanprakash
Shah, Rajesh
Velez, Maria
Natarajan, Yamini
El-Serag, Hashem B.
Petrosino, Joseph F.
Jiao, Li
author_facet Gurwara, Shawn
Ajami, Nadim J.
Jang, Albert
Hessel, Frances C.
Chen, Liang
Plew, Sarah
Wang, Zhensheng
Graham, David Y.
Hair, Clark
White, Donna L.
Kramer, Jennifer
Kourkoumpetis, Themistoklis
Hoffman, Kristi
Cole, Rhonda
Hou, Jason
Husain, Nisreen
Jarbrink-Sehgal, Maria
Hernaez, Ruben
Kanwal, Fasiha
Ketwaroo, Gyanprakash
Shah, Rajesh
Velez, Maria
Natarajan, Yamini
El-Serag, Hashem B.
Petrosino, Joseph F.
Jiao, Li
author_sort Gurwara, Shawn
collection PubMed
description One carbon (1C) metabolism nutrients influence epigenetic regulation and they are supplied by diet and synthesized by gut microbiota. We examined the association between dietary consumption of methyl donors (methionine, betaine and choline) and B vitamins (folate, B2, B6, and B12) and the community composition and structure of the colonic mucosa-associated gut microbiota determined by 16S rRNA gene sequencing in 97 colonic biopsies of 35 men. We used the food frequency questionnaire to assess daily consumption of nutrients, and the UPARSE and SILVA databases for operational taxonomic unit classification. The difference in bacterial diversity and taxonomic relative abundance were compared between low versus high consumption of these nutrients. False discover rate (FDR) adjusted p value < 0.05 indicated statistical significance. The bacterial richness and composition differed significantly by the consumption of folate and B vitamins (p < 0.001). Compared with higher consumption, a lower consumption of these nutrients was associated with a lower abundance of Akkermansia (folate), Roseburia (vitamin B2), and Faecalibacterium (vitamins B2, B6, and B12) but a higher abundance of Erysipelatoclostridium (vitamin B2) (FDR p values < 0.05). The community composition and structure of the colonic bacteria differed significantly by dietary consumption of folate and B vitamins.
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spelling pubmed-64706292019-04-25 Dietary Nutrients Involved in One-Carbon Metabolism and Colonic Mucosa-Associated Gut Microbiome in Individuals with an Endoscopically Normal Colon Gurwara, Shawn Ajami, Nadim J. Jang, Albert Hessel, Frances C. Chen, Liang Plew, Sarah Wang, Zhensheng Graham, David Y. Hair, Clark White, Donna L. Kramer, Jennifer Kourkoumpetis, Themistoklis Hoffman, Kristi Cole, Rhonda Hou, Jason Husain, Nisreen Jarbrink-Sehgal, Maria Hernaez, Ruben Kanwal, Fasiha Ketwaroo, Gyanprakash Shah, Rajesh Velez, Maria Natarajan, Yamini El-Serag, Hashem B. Petrosino, Joseph F. Jiao, Li Nutrients Article One carbon (1C) metabolism nutrients influence epigenetic regulation and they are supplied by diet and synthesized by gut microbiota. We examined the association between dietary consumption of methyl donors (methionine, betaine and choline) and B vitamins (folate, B2, B6, and B12) and the community composition and structure of the colonic mucosa-associated gut microbiota determined by 16S rRNA gene sequencing in 97 colonic biopsies of 35 men. We used the food frequency questionnaire to assess daily consumption of nutrients, and the UPARSE and SILVA databases for operational taxonomic unit classification. The difference in bacterial diversity and taxonomic relative abundance were compared between low versus high consumption of these nutrients. False discover rate (FDR) adjusted p value < 0.05 indicated statistical significance. The bacterial richness and composition differed significantly by the consumption of folate and B vitamins (p < 0.001). Compared with higher consumption, a lower consumption of these nutrients was associated with a lower abundance of Akkermansia (folate), Roseburia (vitamin B2), and Faecalibacterium (vitamins B2, B6, and B12) but a higher abundance of Erysipelatoclostridium (vitamin B2) (FDR p values < 0.05). The community composition and structure of the colonic bacteria differed significantly by dietary consumption of folate and B vitamins. MDPI 2019-03-13 /pmc/articles/PMC6470629/ /pubmed/30871224 http://dx.doi.org/10.3390/nu11030613 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gurwara, Shawn
Ajami, Nadim J.
Jang, Albert
Hessel, Frances C.
Chen, Liang
Plew, Sarah
Wang, Zhensheng
Graham, David Y.
Hair, Clark
White, Donna L.
Kramer, Jennifer
Kourkoumpetis, Themistoklis
Hoffman, Kristi
Cole, Rhonda
Hou, Jason
Husain, Nisreen
Jarbrink-Sehgal, Maria
Hernaez, Ruben
Kanwal, Fasiha
Ketwaroo, Gyanprakash
Shah, Rajesh
Velez, Maria
Natarajan, Yamini
El-Serag, Hashem B.
Petrosino, Joseph F.
Jiao, Li
Dietary Nutrients Involved in One-Carbon Metabolism and Colonic Mucosa-Associated Gut Microbiome in Individuals with an Endoscopically Normal Colon
title Dietary Nutrients Involved in One-Carbon Metabolism and Colonic Mucosa-Associated Gut Microbiome in Individuals with an Endoscopically Normal Colon
title_full Dietary Nutrients Involved in One-Carbon Metabolism and Colonic Mucosa-Associated Gut Microbiome in Individuals with an Endoscopically Normal Colon
title_fullStr Dietary Nutrients Involved in One-Carbon Metabolism and Colonic Mucosa-Associated Gut Microbiome in Individuals with an Endoscopically Normal Colon
title_full_unstemmed Dietary Nutrients Involved in One-Carbon Metabolism and Colonic Mucosa-Associated Gut Microbiome in Individuals with an Endoscopically Normal Colon
title_short Dietary Nutrients Involved in One-Carbon Metabolism and Colonic Mucosa-Associated Gut Microbiome in Individuals with an Endoscopically Normal Colon
title_sort dietary nutrients involved in one-carbon metabolism and colonic mucosa-associated gut microbiome in individuals with an endoscopically normal colon
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470629/
https://www.ncbi.nlm.nih.gov/pubmed/30871224
http://dx.doi.org/10.3390/nu11030613
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