Phenalenones from a Marine-Derived Fungus Penicillium sp.

Six new phenalenone derivatives (1–6), along with five known compounds (7–11) of the herqueinone class, were isolated from a marine-derived fungus Penicillium sp. The absolute configurations of these compounds were assigned based on chemical modifications and their specific rotations. 4-Hydroxyscler...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Sung Chul, Julianti, Elin, Ahn, Sungjin, Kim, Donghwa, Lee, Sang Kook, Noh, Minsoo, Oh, Dong-Chan, Oh, Ki-Bong, Shin, Jongheon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470642/
https://www.ncbi.nlm.nih.gov/pubmed/30889916
http://dx.doi.org/10.3390/md17030176
_version_ 1783411844216520704
author Park, Sung Chul
Julianti, Elin
Ahn, Sungjin
Kim, Donghwa
Lee, Sang Kook
Noh, Minsoo
Oh, Dong-Chan
Oh, Ki-Bong
Shin, Jongheon
author_facet Park, Sung Chul
Julianti, Elin
Ahn, Sungjin
Kim, Donghwa
Lee, Sang Kook
Noh, Minsoo
Oh, Dong-Chan
Oh, Ki-Bong
Shin, Jongheon
author_sort Park, Sung Chul
collection PubMed
description Six new phenalenone derivatives (1–6), along with five known compounds (7–11) of the herqueinone class, were isolated from a marine-derived fungus Penicillium sp. The absolute configurations of these compounds were assigned based on chemical modifications and their specific rotations. 4-Hydroxysclerodin (6) and an acetone adduct of a triketone (7) exhibited moderate anti-angiogenetic and anti-inflammatory activities, respectively, while ent-peniciherqueinone (1) and isoherqueinone (9) exhibited moderate abilities to induce adipogenesis without cytotoxicity.
format Online
Article
Text
id pubmed-6470642
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-64706422019-04-27 Phenalenones from a Marine-Derived Fungus Penicillium sp. Park, Sung Chul Julianti, Elin Ahn, Sungjin Kim, Donghwa Lee, Sang Kook Noh, Minsoo Oh, Dong-Chan Oh, Ki-Bong Shin, Jongheon Mar Drugs Article Six new phenalenone derivatives (1–6), along with five known compounds (7–11) of the herqueinone class, were isolated from a marine-derived fungus Penicillium sp. The absolute configurations of these compounds were assigned based on chemical modifications and their specific rotations. 4-Hydroxysclerodin (6) and an acetone adduct of a triketone (7) exhibited moderate anti-angiogenetic and anti-inflammatory activities, respectively, while ent-peniciherqueinone (1) and isoherqueinone (9) exhibited moderate abilities to induce adipogenesis without cytotoxicity. MDPI 2019-03-18 /pmc/articles/PMC6470642/ /pubmed/30889916 http://dx.doi.org/10.3390/md17030176 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Park, Sung Chul
Julianti, Elin
Ahn, Sungjin
Kim, Donghwa
Lee, Sang Kook
Noh, Minsoo
Oh, Dong-Chan
Oh, Ki-Bong
Shin, Jongheon
Phenalenones from a Marine-Derived Fungus Penicillium sp.
title Phenalenones from a Marine-Derived Fungus Penicillium sp.
title_full Phenalenones from a Marine-Derived Fungus Penicillium sp.
title_fullStr Phenalenones from a Marine-Derived Fungus Penicillium sp.
title_full_unstemmed Phenalenones from a Marine-Derived Fungus Penicillium sp.
title_short Phenalenones from a Marine-Derived Fungus Penicillium sp.
title_sort phenalenones from a marine-derived fungus penicillium sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470642/
https://www.ncbi.nlm.nih.gov/pubmed/30889916
http://dx.doi.org/10.3390/md17030176
work_keys_str_mv AT parksungchul phenalenonesfromamarinederivedfunguspenicilliumsp
AT juliantielin phenalenonesfromamarinederivedfunguspenicilliumsp
AT ahnsungjin phenalenonesfromamarinederivedfunguspenicilliumsp
AT kimdonghwa phenalenonesfromamarinederivedfunguspenicilliumsp
AT leesangkook phenalenonesfromamarinederivedfunguspenicilliumsp
AT nohminsoo phenalenonesfromamarinederivedfunguspenicilliumsp
AT ohdongchan phenalenonesfromamarinederivedfunguspenicilliumsp
AT ohkibong phenalenonesfromamarinederivedfunguspenicilliumsp
AT shinjongheon phenalenonesfromamarinederivedfunguspenicilliumsp

Ejemplares similares