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Anti-Fatigue Activity of Aqueous Extracts of Sonchus arvensis L. in Exercise Trained Mice

Sonchus arvensis L. is a nutritious vegetable and herbal medicine that is consumed worldwide. The aim of this study was to evaluate the anti-fatigue effects and underlying effects of aqueous extract of Sonchus arvensis L. (SA). Male C57BL/6 mice from four groups designated vehicle, exercise, exercis...

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Autores principales: Yuan, Tian, Wu, Di, Sun, Keyu, Tan, Xintong, Wang, Jia, Zhao, Tong, Ren, Bo, Zhao, Beita, Liu, Zhigang, Liu, Xuebo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470720/
https://www.ncbi.nlm.nih.gov/pubmed/30934545
http://dx.doi.org/10.3390/molecules24061168
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author Yuan, Tian
Wu, Di
Sun, Keyu
Tan, Xintong
Wang, Jia
Zhao, Tong
Ren, Bo
Zhao, Beita
Liu, Zhigang
Liu, Xuebo
author_facet Yuan, Tian
Wu, Di
Sun, Keyu
Tan, Xintong
Wang, Jia
Zhao, Tong
Ren, Bo
Zhao, Beita
Liu, Zhigang
Liu, Xuebo
author_sort Yuan, Tian
collection PubMed
description Sonchus arvensis L. is a nutritious vegetable and herbal medicine that is consumed worldwide. The aim of this study was to evaluate the anti-fatigue effects and underlying effects of aqueous extract of Sonchus arvensis L. (SA). Male C57BL/6 mice from four groups designated vehicle, exercise, exercise with low dose (250 mg/kg) or high dose of SA (500 mg/kg), were trained by swimming exercise and orally administrated with SA every other day for 28 days. The anti-fatigue activity was determined by exhaustive swimming test, as well as the muscle structure, levels of blood hemoglobin, and metabolites including lactate and urea nitrogen. SA alleviated mice fatigue behaviors by eliminating metabolites, while improving muscle structure and hemoglobin levels. Moreover, SA enhanced glycogen synthesis of liver but not muscle via increasing GCK and PEPCK gene expressions. Importantly, SA improved antioxidant enzymes expression and activities in both liver and muscle, which was possibly related to its primary components polysaccharides and the antioxidant components including chlorogenic acid, luteolin, and chicoric acid. Taken together, the anti-fatigue effects of SA could be partly explained by its antioxidant activity and mediating effects on glycogen synthesis and metabolites elimination. Therefore, SA could be a potential nutraceutical for improving exercise performance and alleviating physical fatigue.
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spelling pubmed-64707202019-04-26 Anti-Fatigue Activity of Aqueous Extracts of Sonchus arvensis L. in Exercise Trained Mice Yuan, Tian Wu, Di Sun, Keyu Tan, Xintong Wang, Jia Zhao, Tong Ren, Bo Zhao, Beita Liu, Zhigang Liu, Xuebo Molecules Article Sonchus arvensis L. is a nutritious vegetable and herbal medicine that is consumed worldwide. The aim of this study was to evaluate the anti-fatigue effects and underlying effects of aqueous extract of Sonchus arvensis L. (SA). Male C57BL/6 mice from four groups designated vehicle, exercise, exercise with low dose (250 mg/kg) or high dose of SA (500 mg/kg), were trained by swimming exercise and orally administrated with SA every other day for 28 days. The anti-fatigue activity was determined by exhaustive swimming test, as well as the muscle structure, levels of blood hemoglobin, and metabolites including lactate and urea nitrogen. SA alleviated mice fatigue behaviors by eliminating metabolites, while improving muscle structure and hemoglobin levels. Moreover, SA enhanced glycogen synthesis of liver but not muscle via increasing GCK and PEPCK gene expressions. Importantly, SA improved antioxidant enzymes expression and activities in both liver and muscle, which was possibly related to its primary components polysaccharides and the antioxidant components including chlorogenic acid, luteolin, and chicoric acid. Taken together, the anti-fatigue effects of SA could be partly explained by its antioxidant activity and mediating effects on glycogen synthesis and metabolites elimination. Therefore, SA could be a potential nutraceutical for improving exercise performance and alleviating physical fatigue. MDPI 2019-03-25 /pmc/articles/PMC6470720/ /pubmed/30934545 http://dx.doi.org/10.3390/molecules24061168 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yuan, Tian
Wu, Di
Sun, Keyu
Tan, Xintong
Wang, Jia
Zhao, Tong
Ren, Bo
Zhao, Beita
Liu, Zhigang
Liu, Xuebo
Anti-Fatigue Activity of Aqueous Extracts of Sonchus arvensis L. in Exercise Trained Mice
title Anti-Fatigue Activity of Aqueous Extracts of Sonchus arvensis L. in Exercise Trained Mice
title_full Anti-Fatigue Activity of Aqueous Extracts of Sonchus arvensis L. in Exercise Trained Mice
title_fullStr Anti-Fatigue Activity of Aqueous Extracts of Sonchus arvensis L. in Exercise Trained Mice
title_full_unstemmed Anti-Fatigue Activity of Aqueous Extracts of Sonchus arvensis L. in Exercise Trained Mice
title_short Anti-Fatigue Activity of Aqueous Extracts of Sonchus arvensis L. in Exercise Trained Mice
title_sort anti-fatigue activity of aqueous extracts of sonchus arvensis l. in exercise trained mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470720/
https://www.ncbi.nlm.nih.gov/pubmed/30934545
http://dx.doi.org/10.3390/molecules24061168
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