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Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole
Mesostructured ordered silica-based materials are the promising candidates for local drug delivery systems in bone disease due to their uniform pore size and distribution, and high surface area which affect their excellent adsorption properties, good biocompatibility and bioactivity, and versatile f...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470757/ https://www.ncbi.nlm.nih.gov/pubmed/30875887 http://dx.doi.org/10.3390/ijms20061311 |
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author | Czarnobaj, Katarzyna Prokopowicz, Magdalena Greber, Katarzyna |
author_facet | Czarnobaj, Katarzyna Prokopowicz, Magdalena Greber, Katarzyna |
author_sort | Czarnobaj, Katarzyna |
collection | PubMed |
description | Mesostructured ordered silica-based materials are the promising candidates for local drug delivery systems in bone disease due to their uniform pore size and distribution, and high surface area which affect their excellent adsorption properties, good biocompatibility and bioactivity, and versatile functionalization so that their properties can be controlled. Ordered mesoporous silica (MCM-41 type) was synthesized by a surfactant-assisted sol-gel process using tetraethoxysilane as a silica precursor and hexadecyltrimethylammonium bromide as the structure-directing agent. Functionalized silica materials containing various types of organic groups (3-aminopropyl, 3-mercaptopropyl, or 3-glycidyloxypropyl groups) were synthesized by the post-grafting method onto pre-made mesoporous silica. Comparative studies of their structural characteristics, the surface mineralization activity and release properties for the model drug Metronidazole (MT) were then conducted. It has been found that porosity parameters, mineralization activity and adsorption/release of metronidazole from mesoporous channels of silica can be regulated using functional groups which are chemically bounded with an outer silica surface. The preferential mineral nucleation was found on negatively charged surfaces—MCM-41, and mercaptopropyl and glycidyloxypropyl functionalized silica (MCM-SH and MCM-epoxy, respectively) in simulated body fluid (SBF solution), as well as a sustained release of MT. In contrast to them, aminopropyl-functionalized samples (MCM-NH(2)) achieved a high MT release rate. These results confirm the potential of silica-based materials for local therapeutic applications (as drug carriers and bone substitutes) in bone disease. |
format | Online Article Text |
id | pubmed-6470757 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64707572019-04-26 Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole Czarnobaj, Katarzyna Prokopowicz, Magdalena Greber, Katarzyna Int J Mol Sci Article Mesostructured ordered silica-based materials are the promising candidates for local drug delivery systems in bone disease due to their uniform pore size and distribution, and high surface area which affect their excellent adsorption properties, good biocompatibility and bioactivity, and versatile functionalization so that their properties can be controlled. Ordered mesoporous silica (MCM-41 type) was synthesized by a surfactant-assisted sol-gel process using tetraethoxysilane as a silica precursor and hexadecyltrimethylammonium bromide as the structure-directing agent. Functionalized silica materials containing various types of organic groups (3-aminopropyl, 3-mercaptopropyl, or 3-glycidyloxypropyl groups) were synthesized by the post-grafting method onto pre-made mesoporous silica. Comparative studies of their structural characteristics, the surface mineralization activity and release properties for the model drug Metronidazole (MT) were then conducted. It has been found that porosity parameters, mineralization activity and adsorption/release of metronidazole from mesoporous channels of silica can be regulated using functional groups which are chemically bounded with an outer silica surface. The preferential mineral nucleation was found on negatively charged surfaces—MCM-41, and mercaptopropyl and glycidyloxypropyl functionalized silica (MCM-SH and MCM-epoxy, respectively) in simulated body fluid (SBF solution), as well as a sustained release of MT. In contrast to them, aminopropyl-functionalized samples (MCM-NH(2)) achieved a high MT release rate. These results confirm the potential of silica-based materials for local therapeutic applications (as drug carriers and bone substitutes) in bone disease. MDPI 2019-03-15 /pmc/articles/PMC6470757/ /pubmed/30875887 http://dx.doi.org/10.3390/ijms20061311 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Czarnobaj, Katarzyna Prokopowicz, Magdalena Greber, Katarzyna Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole |
title | Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole |
title_full | Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole |
title_fullStr | Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole |
title_full_unstemmed | Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole |
title_short | Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole |
title_sort | use of materials based on polymeric silica as bone-targeted drug delivery systems for metronidazole |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470757/ https://www.ncbi.nlm.nih.gov/pubmed/30875887 http://dx.doi.org/10.3390/ijms20061311 |
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