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Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole

Mesostructured ordered silica-based materials are the promising candidates for local drug delivery systems in bone disease due to their uniform pore size and distribution, and high surface area which affect their excellent adsorption properties, good biocompatibility and bioactivity, and versatile f...

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Detalles Bibliográficos
Autores principales: Czarnobaj, Katarzyna, Prokopowicz, Magdalena, Greber, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470757/
https://www.ncbi.nlm.nih.gov/pubmed/30875887
http://dx.doi.org/10.3390/ijms20061311
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author Czarnobaj, Katarzyna
Prokopowicz, Magdalena
Greber, Katarzyna
author_facet Czarnobaj, Katarzyna
Prokopowicz, Magdalena
Greber, Katarzyna
author_sort Czarnobaj, Katarzyna
collection PubMed
description Mesostructured ordered silica-based materials are the promising candidates for local drug delivery systems in bone disease due to their uniform pore size and distribution, and high surface area which affect their excellent adsorption properties, good biocompatibility and bioactivity, and versatile functionalization so that their properties can be controlled. Ordered mesoporous silica (MCM-41 type) was synthesized by a surfactant-assisted sol-gel process using tetraethoxysilane as a silica precursor and hexadecyltrimethylammonium bromide as the structure-directing agent. Functionalized silica materials containing various types of organic groups (3-aminopropyl, 3-mercaptopropyl, or 3-glycidyloxypropyl groups) were synthesized by the post-grafting method onto pre-made mesoporous silica. Comparative studies of their structural characteristics, the surface mineralization activity and release properties for the model drug Metronidazole (MT) were then conducted. It has been found that porosity parameters, mineralization activity and adsorption/release of metronidazole from mesoporous channels of silica can be regulated using functional groups which are chemically bounded with an outer silica surface. The preferential mineral nucleation was found on negatively charged surfaces—MCM-41, and mercaptopropyl and glycidyloxypropyl functionalized silica (MCM-SH and MCM-epoxy, respectively) in simulated body fluid (SBF solution), as well as a sustained release of MT. In contrast to them, aminopropyl-functionalized samples (MCM-NH(2)) achieved a high MT release rate. These results confirm the potential of silica-based materials for local therapeutic applications (as drug carriers and bone substitutes) in bone disease.
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spelling pubmed-64707572019-04-26 Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole Czarnobaj, Katarzyna Prokopowicz, Magdalena Greber, Katarzyna Int J Mol Sci Article Mesostructured ordered silica-based materials are the promising candidates for local drug delivery systems in bone disease due to their uniform pore size and distribution, and high surface area which affect their excellent adsorption properties, good biocompatibility and bioactivity, and versatile functionalization so that their properties can be controlled. Ordered mesoporous silica (MCM-41 type) was synthesized by a surfactant-assisted sol-gel process using tetraethoxysilane as a silica precursor and hexadecyltrimethylammonium bromide as the structure-directing agent. Functionalized silica materials containing various types of organic groups (3-aminopropyl, 3-mercaptopropyl, or 3-glycidyloxypropyl groups) were synthesized by the post-grafting method onto pre-made mesoporous silica. Comparative studies of their structural characteristics, the surface mineralization activity and release properties for the model drug Metronidazole (MT) were then conducted. It has been found that porosity parameters, mineralization activity and adsorption/release of metronidazole from mesoporous channels of silica can be regulated using functional groups which are chemically bounded with an outer silica surface. The preferential mineral nucleation was found on negatively charged surfaces—MCM-41, and mercaptopropyl and glycidyloxypropyl functionalized silica (MCM-SH and MCM-epoxy, respectively) in simulated body fluid (SBF solution), as well as a sustained release of MT. In contrast to them, aminopropyl-functionalized samples (MCM-NH(2)) achieved a high MT release rate. These results confirm the potential of silica-based materials for local therapeutic applications (as drug carriers and bone substitutes) in bone disease. MDPI 2019-03-15 /pmc/articles/PMC6470757/ /pubmed/30875887 http://dx.doi.org/10.3390/ijms20061311 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Czarnobaj, Katarzyna
Prokopowicz, Magdalena
Greber, Katarzyna
Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole
title Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole
title_full Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole
title_fullStr Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole
title_full_unstemmed Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole
title_short Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole
title_sort use of materials based on polymeric silica as bone-targeted drug delivery systems for metronidazole
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470757/
https://www.ncbi.nlm.nih.gov/pubmed/30875887
http://dx.doi.org/10.3390/ijms20061311
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