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Synthesis, Evaluation, and Mechanism Study of New Tepotinib Derivatives as Antiproliferative Agents

Inspired by the potent inhibition activity of the c-Met (mesenchymal−epithelial transition factor) inhibitor Tepotinib, a series of new Tepotinib derivatives were synthesized and evaluated for their ability to act as antiproliferative agents to find the leading compounds with good activity and limit...

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Detalles Bibliográficos
Autores principales: Zhang, Niu-niu, An, Bai-jiao, Zhou, Yan, Li, Xing-shu, Yan, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470795/
https://www.ncbi.nlm.nih.gov/pubmed/30934578
http://dx.doi.org/10.3390/molecules24061173