Discovery of Stealthin Derivatives and Implication of the Amidotransferase FlsN3 in the Biosynthesis of Nitrogen-Containing Fluostatins

Diazobenzofluorene-containing atypical angucyclines exhibit promising biological activities. Here we report the inactivation of an amidotransferase-encoding gene flsN3 in Micromonospora rosaria SCSIO N160, a producer of fluostatins. Bioinformatics analysis indicated that FlsN3 was involved in the di...

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Detalles Bibliográficos
Autores principales: Huang, Chunshuai, Yang, Chunfang, Fang, Zhuangjie, Zhang, Liping, Zhang, Wenjun, Zhu, Yiguang, Zhang, Changsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470958/
https://www.ncbi.nlm.nih.gov/pubmed/30836614
http://dx.doi.org/10.3390/md17030150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470958/
https://www.ncbi.nlm.nih.gov/pubmed/30836614
http://dx.doi.org/10.3390/md17030150

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