Two New Piperazine-Triones from a Marine-Derived Streptomycetes sp. Strain SMS636

Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the isol...

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Autores principales: Xu, Xiuli, Han, Jiahui, Lin, Rui, Polyak, Steven W., Song, Fuhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471054/
https://www.ncbi.nlm.nih.gov/pubmed/30901830
http://dx.doi.org/10.3390/md17030186
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author Xu, Xiuli
Han, Jiahui
Lin, Rui
Polyak, Steven W.
Song, Fuhang
author_facet Xu, Xiuli
Han, Jiahui
Lin, Rui
Polyak, Steven W.
Song, Fuhang
author_sort Xu, Xiuli
collection PubMed
description Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the isolated compounds were confirmed by comprehensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR. Compound 4 exhibited moderate antibacterial activities against Staphylococcus aureus and methicillin resistant S. aureus (MRSA) with Minimum Inhibitory Concentration (MIC) values of 12.5 and 25 μg/mL, respectively. Compound 6 displayed significant antibacterial activities against S. aureus, MRSA and Bacillus Calmette-Guérin (BCG) with MIC values of 0.78, 0.78 and 1.25 μg/mL, respectively.
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spelling pubmed-64710542019-04-27 Two New Piperazine-Triones from a Marine-Derived Streptomycetes sp. Strain SMS636 Xu, Xiuli Han, Jiahui Lin, Rui Polyak, Steven W. Song, Fuhang Mar Drugs Article Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the isolated compounds were confirmed by comprehensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR. Compound 4 exhibited moderate antibacterial activities against Staphylococcus aureus and methicillin resistant S. aureus (MRSA) with Minimum Inhibitory Concentration (MIC) values of 12.5 and 25 μg/mL, respectively. Compound 6 displayed significant antibacterial activities against S. aureus, MRSA and Bacillus Calmette-Guérin (BCG) with MIC values of 0.78, 0.78 and 1.25 μg/mL, respectively. MDPI 2019-03-21 /pmc/articles/PMC6471054/ /pubmed/30901830 http://dx.doi.org/10.3390/md17030186 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xu, Xiuli
Han, Jiahui
Lin, Rui
Polyak, Steven W.
Song, Fuhang
Two New Piperazine-Triones from a Marine-Derived Streptomycetes sp. Strain SMS636
title Two New Piperazine-Triones from a Marine-Derived Streptomycetes sp. Strain SMS636
title_full Two New Piperazine-Triones from a Marine-Derived Streptomycetes sp. Strain SMS636
title_fullStr Two New Piperazine-Triones from a Marine-Derived Streptomycetes sp. Strain SMS636
title_full_unstemmed Two New Piperazine-Triones from a Marine-Derived Streptomycetes sp. Strain SMS636
title_short Two New Piperazine-Triones from a Marine-Derived Streptomycetes sp. Strain SMS636
title_sort two new piperazine-triones from a marine-derived streptomycetes sp. strain sms636
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471054/
https://www.ncbi.nlm.nih.gov/pubmed/30901830
http://dx.doi.org/10.3390/md17030186
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