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Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats

Obesity is intimately related to a chronic inflammatory state, with augmentation of macrophage infiltration and pro-inflammatory cytokine secretion in white adipose tissue (WAT) and mitochondrial dysfunction in skeletal muscle. The specific aim of this study is to evaluate effects of tartary buckwhe...

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Autores principales: Kim, Seog-Young, Lee, Mak-Soon, Chang, Eugene, Jung, Sunyoon, Ko, Hyunmi, Lee, Eunyoung, Lee, Soojin, Kim, Chong-Tai, Kim, In-Hwan, Kim, Yangha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471111/
https://www.ncbi.nlm.nih.gov/pubmed/30889894
http://dx.doi.org/10.3390/nu11030654
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author Kim, Seog-Young
Lee, Mak-Soon
Chang, Eugene
Jung, Sunyoon
Ko, Hyunmi
Lee, Eunyoung
Lee, Soojin
Kim, Chong-Tai
Kim, In-Hwan
Kim, Yangha
author_facet Kim, Seog-Young
Lee, Mak-Soon
Chang, Eugene
Jung, Sunyoon
Ko, Hyunmi
Lee, Eunyoung
Lee, Soojin
Kim, Chong-Tai
Kim, In-Hwan
Kim, Yangha
author_sort Kim, Seog-Young
collection PubMed
description Obesity is intimately related to a chronic inflammatory state, with augmentation of macrophage infiltration and pro-inflammatory cytokine secretion in white adipose tissue (WAT) and mitochondrial dysfunction in skeletal muscle. The specific aim of this study is to evaluate effects of tartary buckwheat extract (TB) on obesity-induced adipose tissue inflammation and muscle peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α/sirtulin 1 (SIRT1) pathway in rats fed a high-fat diet. Sprague-Dawley rats were divided into four groups and fed either a normal diet (NOR), 45% high-fat diet (HF), HF + low dose of TB (TB-L; 5 g/kg diet), or HF + high dose of TB (TB-H; 10 g/kg diet) for 13 weeks. TB significantly reduced adipose tissue mass with decreased adipogenic gene expression of PPAR-γ and aP2. Serum nitric oxide levels and adipose tissue macrophage M1 polarization gene markers, such as iNOS, CD11c, and Arg1, and pro-inflammatory gene expression, including TNF-α, IL-6, and MCP-1, were remarkably downregulated in the TB-L and TB-H groups. Moreover, TB supplementation increased gene expression of PGC-1α and SIRT1, involved in muscle biogenesis and function. These results suggested that TB might attenuate obesity-induced inflammation and mitochondrial dysfunction by modulating adipose tissue inflammation and the muscle PGC-1α/SIRT1 pathway.
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spelling pubmed-64711112019-04-25 Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats Kim, Seog-Young Lee, Mak-Soon Chang, Eugene Jung, Sunyoon Ko, Hyunmi Lee, Eunyoung Lee, Soojin Kim, Chong-Tai Kim, In-Hwan Kim, Yangha Nutrients Article Obesity is intimately related to a chronic inflammatory state, with augmentation of macrophage infiltration and pro-inflammatory cytokine secretion in white adipose tissue (WAT) and mitochondrial dysfunction in skeletal muscle. The specific aim of this study is to evaluate effects of tartary buckwheat extract (TB) on obesity-induced adipose tissue inflammation and muscle peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α/sirtulin 1 (SIRT1) pathway in rats fed a high-fat diet. Sprague-Dawley rats were divided into four groups and fed either a normal diet (NOR), 45% high-fat diet (HF), HF + low dose of TB (TB-L; 5 g/kg diet), or HF + high dose of TB (TB-H; 10 g/kg diet) for 13 weeks. TB significantly reduced adipose tissue mass with decreased adipogenic gene expression of PPAR-γ and aP2. Serum nitric oxide levels and adipose tissue macrophage M1 polarization gene markers, such as iNOS, CD11c, and Arg1, and pro-inflammatory gene expression, including TNF-α, IL-6, and MCP-1, were remarkably downregulated in the TB-L and TB-H groups. Moreover, TB supplementation increased gene expression of PGC-1α and SIRT1, involved in muscle biogenesis and function. These results suggested that TB might attenuate obesity-induced inflammation and mitochondrial dysfunction by modulating adipose tissue inflammation and the muscle PGC-1α/SIRT1 pathway. MDPI 2019-03-18 /pmc/articles/PMC6471111/ /pubmed/30889894 http://dx.doi.org/10.3390/nu11030654 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Seog-Young
Lee, Mak-Soon
Chang, Eugene
Jung, Sunyoon
Ko, Hyunmi
Lee, Eunyoung
Lee, Soojin
Kim, Chong-Tai
Kim, In-Hwan
Kim, Yangha
Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats
title Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats
title_full Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats
title_fullStr Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats
title_full_unstemmed Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats
title_short Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats
title_sort tartary buckwheat extract attenuated the obesity-induced inflammation and increased muscle pgc-1a/sirt1 expression in high fat diet-induced obese rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471111/
https://www.ncbi.nlm.nih.gov/pubmed/30889894
http://dx.doi.org/10.3390/nu11030654
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