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Microbial Transformation of Flavonoids by Isaria fumosorosea ACCC 37814
Glycosylation is an efficient strategy to modulate the solubility, stability, bioavailability and bioactivity of drug-like natural products. Biological methods, such as whole-cell biocatalyst, promise a simple but highly effective approach to glycosylate biologically active small molecules with rema...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471136/ https://www.ncbi.nlm.nih.gov/pubmed/30875913 http://dx.doi.org/10.3390/molecules24061028 |
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author | Dou, Fangmin Wang, Zhi Li, Guiying Dun, Baoqing |
author_facet | Dou, Fangmin Wang, Zhi Li, Guiying Dun, Baoqing |
author_sort | Dou, Fangmin |
collection | PubMed |
description | Glycosylation is an efficient strategy to modulate the solubility, stability, bioavailability and bioactivity of drug-like natural products. Biological methods, such as whole-cell biocatalyst, promise a simple but highly effective approach to glycosylate biologically active small molecules with remarkable regio- and stereo-selectivity. Herein, we use the entomopathogenic filamentous fungus Isaria fumosorosea ACCC 37814 to biotransform a panel of phenolic natural products, including flavonoids and anthraquinone, into their glycosides. Six new flavonoid (4-O-methyl)glucopyranosides are obtained and structurally characterized using high resolution mass and nuclear magnetic resonance spectroscopic techniques. These compounds further expand the structural diversity of flavonoid glycosides and may be used in biological study. |
format | Online Article Text |
id | pubmed-6471136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64711362019-04-26 Microbial Transformation of Flavonoids by Isaria fumosorosea ACCC 37814 Dou, Fangmin Wang, Zhi Li, Guiying Dun, Baoqing Molecules Article Glycosylation is an efficient strategy to modulate the solubility, stability, bioavailability and bioactivity of drug-like natural products. Biological methods, such as whole-cell biocatalyst, promise a simple but highly effective approach to glycosylate biologically active small molecules with remarkable regio- and stereo-selectivity. Herein, we use the entomopathogenic filamentous fungus Isaria fumosorosea ACCC 37814 to biotransform a panel of phenolic natural products, including flavonoids and anthraquinone, into their glycosides. Six new flavonoid (4-O-methyl)glucopyranosides are obtained and structurally characterized using high resolution mass and nuclear magnetic resonance spectroscopic techniques. These compounds further expand the structural diversity of flavonoid glycosides and may be used in biological study. MDPI 2019-03-15 /pmc/articles/PMC6471136/ /pubmed/30875913 http://dx.doi.org/10.3390/molecules24061028 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Dou, Fangmin Wang, Zhi Li, Guiying Dun, Baoqing Microbial Transformation of Flavonoids by Isaria fumosorosea ACCC 37814 |
title | Microbial Transformation of Flavonoids by Isaria fumosorosea ACCC 37814 |
title_full | Microbial Transformation of Flavonoids by Isaria fumosorosea ACCC 37814 |
title_fullStr | Microbial Transformation of Flavonoids by Isaria fumosorosea ACCC 37814 |
title_full_unstemmed | Microbial Transformation of Flavonoids by Isaria fumosorosea ACCC 37814 |
title_short | Microbial Transformation of Flavonoids by Isaria fumosorosea ACCC 37814 |
title_sort | microbial transformation of flavonoids by isaria fumosorosea accc 37814 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471136/ https://www.ncbi.nlm.nih.gov/pubmed/30875913 http://dx.doi.org/10.3390/molecules24061028 |
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