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Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation

Bioinspired stem cell-based hard tissue engineering includes numerous aspects: The synthesis and fabrication of appropriate scaffold materials, their analytical characterization, and guided osteogenesis using the sustained release of osteoinducing and/or osteoconducting drugs for mesenchymal stem ce...

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Autores principales: Götz, Werner, Tobiasch, Edda, Witzleben, Steffen, Schulze, Margit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471146/
https://www.ncbi.nlm.nih.gov/pubmed/30871062
http://dx.doi.org/10.3390/pharmaceutics11030117
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author Götz, Werner
Tobiasch, Edda
Witzleben, Steffen
Schulze, Margit
author_facet Götz, Werner
Tobiasch, Edda
Witzleben, Steffen
Schulze, Margit
author_sort Götz, Werner
collection PubMed
description Bioinspired stem cell-based hard tissue engineering includes numerous aspects: The synthesis and fabrication of appropriate scaffold materials, their analytical characterization, and guided osteogenesis using the sustained release of osteoinducing and/or osteoconducting drugs for mesenchymal stem cell differentiation, growth, and proliferation. Here, the effect of silicon- and silicate-containing materials on osteogenesis at the molecular level has been a particular focus within the last decade. This review summarizes recently published scientific results, including material developments and analysis, with a special focus on silicon hybrid bone composites. First, the sources, bioavailability, and functions of silicon on various tissues are discussed. The second focus is on the effects of calcium-silicate biomineralization and corresponding analytical methods in investigating osteogenesis and bone formation. Finally, recent developments in the manufacturing of Si-containing scaffolds are discussed, including in vitro and in vivo studies, as well as recently filed patents that focus on the influence of silicon on hard tissue formation.
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spelling pubmed-64711462019-04-27 Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation Götz, Werner Tobiasch, Edda Witzleben, Steffen Schulze, Margit Pharmaceutics Review Bioinspired stem cell-based hard tissue engineering includes numerous aspects: The synthesis and fabrication of appropriate scaffold materials, their analytical characterization, and guided osteogenesis using the sustained release of osteoinducing and/or osteoconducting drugs for mesenchymal stem cell differentiation, growth, and proliferation. Here, the effect of silicon- and silicate-containing materials on osteogenesis at the molecular level has been a particular focus within the last decade. This review summarizes recently published scientific results, including material developments and analysis, with a special focus on silicon hybrid bone composites. First, the sources, bioavailability, and functions of silicon on various tissues are discussed. The second focus is on the effects of calcium-silicate biomineralization and corresponding analytical methods in investigating osteogenesis and bone formation. Finally, recent developments in the manufacturing of Si-containing scaffolds are discussed, including in vitro and in vivo studies, as well as recently filed patents that focus on the influence of silicon on hard tissue formation. MDPI 2019-03-12 /pmc/articles/PMC6471146/ /pubmed/30871062 http://dx.doi.org/10.3390/pharmaceutics11030117 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Götz, Werner
Tobiasch, Edda
Witzleben, Steffen
Schulze, Margit
Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation
title Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation
title_full Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation
title_fullStr Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation
title_full_unstemmed Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation
title_short Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation
title_sort effects of silicon compounds on biomineralization, osteogenesis, and hard tissue formation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471146/
https://www.ncbi.nlm.nih.gov/pubmed/30871062
http://dx.doi.org/10.3390/pharmaceutics11030117
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