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Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation
Bioinspired stem cell-based hard tissue engineering includes numerous aspects: The synthesis and fabrication of appropriate scaffold materials, their analytical characterization, and guided osteogenesis using the sustained release of osteoinducing and/or osteoconducting drugs for mesenchymal stem ce...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471146/ https://www.ncbi.nlm.nih.gov/pubmed/30871062 http://dx.doi.org/10.3390/pharmaceutics11030117 |
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author | Götz, Werner Tobiasch, Edda Witzleben, Steffen Schulze, Margit |
author_facet | Götz, Werner Tobiasch, Edda Witzleben, Steffen Schulze, Margit |
author_sort | Götz, Werner |
collection | PubMed |
description | Bioinspired stem cell-based hard tissue engineering includes numerous aspects: The synthesis and fabrication of appropriate scaffold materials, their analytical characterization, and guided osteogenesis using the sustained release of osteoinducing and/or osteoconducting drugs for mesenchymal stem cell differentiation, growth, and proliferation. Here, the effect of silicon- and silicate-containing materials on osteogenesis at the molecular level has been a particular focus within the last decade. This review summarizes recently published scientific results, including material developments and analysis, with a special focus on silicon hybrid bone composites. First, the sources, bioavailability, and functions of silicon on various tissues are discussed. The second focus is on the effects of calcium-silicate biomineralization and corresponding analytical methods in investigating osteogenesis and bone formation. Finally, recent developments in the manufacturing of Si-containing scaffolds are discussed, including in vitro and in vivo studies, as well as recently filed patents that focus on the influence of silicon on hard tissue formation. |
format | Online Article Text |
id | pubmed-6471146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64711462019-04-27 Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation Götz, Werner Tobiasch, Edda Witzleben, Steffen Schulze, Margit Pharmaceutics Review Bioinspired stem cell-based hard tissue engineering includes numerous aspects: The synthesis and fabrication of appropriate scaffold materials, their analytical characterization, and guided osteogenesis using the sustained release of osteoinducing and/or osteoconducting drugs for mesenchymal stem cell differentiation, growth, and proliferation. Here, the effect of silicon- and silicate-containing materials on osteogenesis at the molecular level has been a particular focus within the last decade. This review summarizes recently published scientific results, including material developments and analysis, with a special focus on silicon hybrid bone composites. First, the sources, bioavailability, and functions of silicon on various tissues are discussed. The second focus is on the effects of calcium-silicate biomineralization and corresponding analytical methods in investigating osteogenesis and bone formation. Finally, recent developments in the manufacturing of Si-containing scaffolds are discussed, including in vitro and in vivo studies, as well as recently filed patents that focus on the influence of silicon on hard tissue formation. MDPI 2019-03-12 /pmc/articles/PMC6471146/ /pubmed/30871062 http://dx.doi.org/10.3390/pharmaceutics11030117 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Götz, Werner Tobiasch, Edda Witzleben, Steffen Schulze, Margit Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation |
title | Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation |
title_full | Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation |
title_fullStr | Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation |
title_full_unstemmed | Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation |
title_short | Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation |
title_sort | effects of silicon compounds on biomineralization, osteogenesis, and hard tissue formation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471146/ https://www.ncbi.nlm.nih.gov/pubmed/30871062 http://dx.doi.org/10.3390/pharmaceutics11030117 |
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