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Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO-1) Inhibitors Based on Ortho-Naphthaquinone-Containing Natural Product

There is great interest in developing small molecules agents capable of reversing tumor immune escape to restore the body’s immune system. As an immunosuppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO-1) is considered a promising target for oncology immunotherapy. Currently, none of IDO-1 inhib...

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Detalles Bibliográficos
Autores principales:	Zhao, Hongchuan, Sun, Pu, Guo, Wei, Wang, Yi, Zhang, Ao, Meng, Linghua, Ding, Chunyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471201/ https://www.ncbi.nlm.nih.gov/pubmed/30889860 http://dx.doi.org/10.3390/molecules24061059

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