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Metabolism of Stilbenoids by Human Faecal Microbiota
Stilbenoids are dietary phenolics with notable biological effects on humans. Epidemiological, clinical, and nutritional studies from recent years have confirmed the significant biological effects of stilbenoids, such as oxidative stress protection and the prevention of degenerative diseases, includi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471231/ https://www.ncbi.nlm.nih.gov/pubmed/30909544 http://dx.doi.org/10.3390/molecules24061155 |
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author | Jarosova, Veronika Vesely, Ondrej Marsik, Petr Jaimes, Jose Diogenes Smejkal, Karel Kloucek, Pavel Havlik, Jaroslav |
author_facet | Jarosova, Veronika Vesely, Ondrej Marsik, Petr Jaimes, Jose Diogenes Smejkal, Karel Kloucek, Pavel Havlik, Jaroslav |
author_sort | Jarosova, Veronika |
collection | PubMed |
description | Stilbenoids are dietary phenolics with notable biological effects on humans. Epidemiological, clinical, and nutritional studies from recent years have confirmed the significant biological effects of stilbenoids, such as oxidative stress protection and the prevention of degenerative diseases, including cancer, cardiovascular diseases, and neurodegenerative diseases. Stilbenoids are intensively metabolically transformed by colon microbiota, and their corresponding metabolites might show different or stronger biological activity than their parent molecules. The aim of the present study was to determine the metabolism of six stilbenoids (resveratrol, oxyresveratrol, piceatannol, thunalbene, batatasin III, and pinostilbene), mediated by colon microbiota. Stilbenoids were fermented in an in vitro faecal fermentation system using fresh faeces from five different donors as an inoculum. The samples of metabolized stilbenoids were collected at 0, 2, 4, 8, 24, and 48 h. Significant differences in the microbial transformation among stilbene derivatives were observed by liquid chromatography mass spectrometry (LC/MS). Four stilbenoids (resveratrol, oxyresveratrol, piceatannol and thunalbene) were metabolically transformed by double bond reduction, dihydroxylation, and demethylation, while batatasin III and pinostilbene were stable under conditions simulating the colon environment. Strong inter-individual differences in speed, intensity, and pathways of metabolism were observed among the faecal samples obtained from the donors. |
format | Online Article Text |
id | pubmed-6471231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64712312019-04-26 Metabolism of Stilbenoids by Human Faecal Microbiota Jarosova, Veronika Vesely, Ondrej Marsik, Petr Jaimes, Jose Diogenes Smejkal, Karel Kloucek, Pavel Havlik, Jaroslav Molecules Article Stilbenoids are dietary phenolics with notable biological effects on humans. Epidemiological, clinical, and nutritional studies from recent years have confirmed the significant biological effects of stilbenoids, such as oxidative stress protection and the prevention of degenerative diseases, including cancer, cardiovascular diseases, and neurodegenerative diseases. Stilbenoids are intensively metabolically transformed by colon microbiota, and their corresponding metabolites might show different or stronger biological activity than their parent molecules. The aim of the present study was to determine the metabolism of six stilbenoids (resveratrol, oxyresveratrol, piceatannol, thunalbene, batatasin III, and pinostilbene), mediated by colon microbiota. Stilbenoids were fermented in an in vitro faecal fermentation system using fresh faeces from five different donors as an inoculum. The samples of metabolized stilbenoids were collected at 0, 2, 4, 8, 24, and 48 h. Significant differences in the microbial transformation among stilbene derivatives were observed by liquid chromatography mass spectrometry (LC/MS). Four stilbenoids (resveratrol, oxyresveratrol, piceatannol and thunalbene) were metabolically transformed by double bond reduction, dihydroxylation, and demethylation, while batatasin III and pinostilbene were stable under conditions simulating the colon environment. Strong inter-individual differences in speed, intensity, and pathways of metabolism were observed among the faecal samples obtained from the donors. MDPI 2019-03-23 /pmc/articles/PMC6471231/ /pubmed/30909544 http://dx.doi.org/10.3390/molecules24061155 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jarosova, Veronika Vesely, Ondrej Marsik, Petr Jaimes, Jose Diogenes Smejkal, Karel Kloucek, Pavel Havlik, Jaroslav Metabolism of Stilbenoids by Human Faecal Microbiota |
title | Metabolism of Stilbenoids by Human Faecal Microbiota |
title_full | Metabolism of Stilbenoids by Human Faecal Microbiota |
title_fullStr | Metabolism of Stilbenoids by Human Faecal Microbiota |
title_full_unstemmed | Metabolism of Stilbenoids by Human Faecal Microbiota |
title_short | Metabolism of Stilbenoids by Human Faecal Microbiota |
title_sort | metabolism of stilbenoids by human faecal microbiota |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471231/ https://www.ncbi.nlm.nih.gov/pubmed/30909544 http://dx.doi.org/10.3390/molecules24061155 |
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