Cargando…

Zoledronate Enhances Osteocyte-Mediated Osteoclast Differentiation by IL-6/RANKL Axis

Bisphosphonates are one of the most widely used synthetic pyrophosphate analogues for the treatment of bone resorbing diseases such as osteoporosis, multiple myeloma, and bone metastases. Although the therapeutic usefulness of bisphosphonates mainly depends on their anti-osteoclastogenic effect, a s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Hyung Joon, Kim, Ha Jin, Choi, YunJeong, Bae, Moon-Kyoung, Hwang, Dae Seok, Shin, Sang-Hun, Lee, Jae-Yeol
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471260/ https://www.ncbi.nlm.nih.gov/pubmed/30909508 http://dx.doi.org/10.3390/ijms20061467

Ejemplares similares

Sclerostin Stimulates Osteocyte Support of Osteoclast Activity by a RANKL-Dependent Pathway
por: Wijenayaka, Asiri R., et al.
Publicado: (2011)

TNF-α Directly Enhances Osteocyte RANKL Expression and Promotes Osteoclast Formation
por: Marahleh, Aseel, et al.
Publicado: (2019)

Calcium-Phosphate Crystals Promote RANKL Expression via the Downregulation of DUSP1
por: Choi, YunJeong, et al.
Publicado: (2019)

Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone
por: Xiong, Jinhu, et al.
Publicado: (2015)

Osteoclast-derived IGF1 induces RANKL production in osteocytes and contributes to pagetic lesion formation
por: Miyagawa, Kazuaki, et al.
Publicado: (2023)

Serum amyloid A inhibits RANKL-induced osteoclast formation
por: Oh, Eunseo, et al.
Publicado: (2015)

Magnolol Inhibits Osteoclast Differentiation via Suppression of RANKL Expression
por: Hwang, Youn-Hwan, et al.
Publicado: (2018)

Connective tissue growth factor (CTGF) regulates the fusion of osteoclast precursors by inhibiting Bcl6 in periodontitis
por: Choi, YunJeong, et al.
Publicado: (2020)

Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence
por: Kim, Ha-Neui, et al.
Publicado: (2020)

The crucial role of osteocyte-derived RANKL in bone homeostasis
por: Nakashima, Tomoki, et al.
Publicado: (2012)

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation
por: Kim, Kabsun, et al.
Publicado: (2015)

Identification of an intronic enhancer regulating RANKL expression in osteocytic cells
por: Yan, Minglu, et al.
Publicado: (2023)

Suppressive effects of (-)-tubaic acid on RANKL-induced osteoclast differentiation and bone resorption
por: Lim, Soomin, et al.
Publicado: (2023)

Signaling crosstalk between RANKL and interferons in osteoclast differentiation
por: Takayanagi, Hiroshi, et al.
Publicado: (2002)

IRF2 enhances RANKL-induced osteoclast differentiation via regulating NF-κB/NFATc1 signaling
por: Kim, Inyoung, et al.
Publicado: (2021)

Osteocyte Network; a Negative Regulatory System for Bone Mass Augmented by the Induction of Rankl in Osteoblasts and Sost in Osteocytes at Unloading
por: Moriishi, Takeshi, et al.
Publicado: (2012)

Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption
por: Kitaura, Hideki, et al.
Publicado: (2020)

How zoledronic acid improves osteoporosis by acting on osteoclasts
por: Wang, Biao, et al.
Publicado: (2022)

Heme oxygenase-1 (HO-1)/carbon monoxide (CO) axis suppresses RANKL-induced osteoclastic differentiation by inhibiting redox-sensitive NF-κB activation
por: Bak, Sun-Uk, et al.
Publicado: (2017)

Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression
por: Shoji-Matsunaga, Ayumi, et al.
Publicado: (2017)

Effect of TNF-α on osteocyte RANKL expression during orthodontic tooth movement
por: Marahleh, Aseel, et al.
Publicado: (2021)

Structural insights into the binding of zoledronic acid with RANKL via computational simulations
por: Wang, Ruijie, et al.
Publicado: (2022)

Carboxypeptidase E Is a Novel Modulator of RANKL-Induced Osteoclast Differentiation
por: Kim, Hyun-Ju, et al.
Publicado: (2014)

Vav1 inhibits RANKL-induced osteoclast differentiation and bone resorption
por: Jang, Jin Sun, et al.
Publicado: (2019)

Tumor necrosis factor-α antagonist diminishes osteocytic RANKL and sclerostin expression in diabetes rats with periodontitis
por: Kim, Ji-Hye, et al.
Publicado: (2017)

Mechanical Loading Reduces Inflammation-Induced Human Osteocyte-to-Osteoclast Communication
por: Pathak, Janak L., et al.
Publicado: (2015)

Selective Regulation of MAPK Signaling Mediates RANKL-dependent Osteoclast Differentiation
por: Lee, Kyunghee, et al.
Publicado: (2016)

FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2
por: Park, Min Young, et al.
Publicado: (2017)

Effects of Melandrium firmum Rohrbach on RANKL-induced osteoclast differentiation and OVX rats
por: Kim, Minsun, et al.
Publicado: (2021)

Minimally effective concentration of zoledronic acid to suppress osteoclasts in vitro
por: Li, Pengfei, et al.
Publicado: (2018)

S100A9 Increases IL-6 and RANKL Expressions through MAPKs and STAT3 Signaling Pathways in Osteocyte-Like Cells
por: Takagi, Ryosuke, et al.
Publicado: (2020)

ECSIT is essential for RANKL-induced stimulation of mitochondria in osteoclasts and a target for the anti-osteoclastogenic effects of estrogens
por: Marques-Carvalho, Adriana, et al.
Publicado: (2023)

Letrozole Suppresses the Fusion of Osteoclast Precursors through Inhibition of p38-Mediated DC-STAMP Pathway
por: Kim, Hyung Joon, et al.
Publicado: (2020)

NRROS Negatively Regulates Osteoclast Differentiation by Inhibiting RANKL-Mediated NF-κB and Reactive Oxygen Species Pathways
por: Kim, Jung Ha, et al.
Publicado: (2015)

Effect of Denosumab on the Change of Osteoclast Precursors Compared to Zoledronate Treatment in Postmenopausal Women with Osteoporosis
por: Kong, Sung Hye, et al.
Publicado: (2022)

RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro
por: Sutherland, Karen A, et al.
Publicado: (2009)

Fucoidan, a Sulfated Polysaccharide, Inhibits Osteoclast Differentiation and Function by Modulating RANKL Signaling
por: Kim, Young Woo, et al.
Publicado: (2014)

Effect on Osteoclast Differentiation and ER Stress Downregulation by Amygdalin and RANKL Binding Interaction
por: Trang, Nguyen Minh, et al.
Publicado: (2022)

Loss of menin in osteoblast lineage affects osteocyte–osteoclast crosstalk causing osteoporosis
por: Liu, Peng, et al.
Publicado: (2017)

Triple Culture of Primary Human Osteoblasts, Osteoclasts and Osteocytes as an In Vitro Bone Model
por: Bernhardt, Anne, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nsrto3gctv3p0fkrijn5bmasl2