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Wire Electrodes Embedded in Artificial Conduit for Long-term Monitoring of the Peripheral Nerve Signal

Massive efforts to develop neural interfaces have been made for controlling prosthetic limbs according to the will of the patient, with the ultimate goal being long-term implantation. One of the major struggles is that the electrode’s performance degrades over time due to scar formation. Herein, we...

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Autores principales: Jung, Woohyun, Jung, Sunyoung, Kim, Ockchul, Park, HyungDal, Choi, Wonsuk, Son, Donghee, Chung, Seok, Kim, Jinseok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471311/
https://www.ncbi.nlm.nih.gov/pubmed/30871203
http://dx.doi.org/10.3390/mi10030184
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author Jung, Woohyun
Jung, Sunyoung
Kim, Ockchul
Park, HyungDal
Choi, Wonsuk
Son, Donghee
Chung, Seok
Kim, Jinseok
author_facet Jung, Woohyun
Jung, Sunyoung
Kim, Ockchul
Park, HyungDal
Choi, Wonsuk
Son, Donghee
Chung, Seok
Kim, Jinseok
author_sort Jung, Woohyun
collection PubMed
description Massive efforts to develop neural interfaces have been made for controlling prosthetic limbs according to the will of the patient, with the ultimate goal being long-term implantation. One of the major struggles is that the electrode’s performance degrades over time due to scar formation. Herein, we have developed peripheral nerve electrodes with a cone-shaped flexible artificial conduit capable of protecting wire electrodes from scar formation. The wire electrodes, which are composed of biocompatible alloy materials, were embedded in the conduit where the inside was filled with collagen to allow the damaged nerves to regenerate into the conduit and interface with the wire electrodes. After implanting the wire electrodes into the sciatic nerve of a rat, we successfully recorded the peripheral neural signals while providing mechanical stimulation. Remarkably, we observed the external stimuli-induced nerve signals at 19 weeks after implantation. This is possibly due to axon regeneration inside our platform. To verify the tissue response of our electrodes to the sciatic nerve, we performed immunohistochemistry (IHC) and observed axon regeneration without scar tissue forming inside the conduit. Thus, our strategy has proven that our neural interface can play a significant role in the long-term monitoring of the peripheral nerve signal.
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spelling pubmed-64713112019-04-27 Wire Electrodes Embedded in Artificial Conduit for Long-term Monitoring of the Peripheral Nerve Signal Jung, Woohyun Jung, Sunyoung Kim, Ockchul Park, HyungDal Choi, Wonsuk Son, Donghee Chung, Seok Kim, Jinseok Micromachines (Basel) Article Massive efforts to develop neural interfaces have been made for controlling prosthetic limbs according to the will of the patient, with the ultimate goal being long-term implantation. One of the major struggles is that the electrode’s performance degrades over time due to scar formation. Herein, we have developed peripheral nerve electrodes with a cone-shaped flexible artificial conduit capable of protecting wire electrodes from scar formation. The wire electrodes, which are composed of biocompatible alloy materials, were embedded in the conduit where the inside was filled with collagen to allow the damaged nerves to regenerate into the conduit and interface with the wire electrodes. After implanting the wire electrodes into the sciatic nerve of a rat, we successfully recorded the peripheral neural signals while providing mechanical stimulation. Remarkably, we observed the external stimuli-induced nerve signals at 19 weeks after implantation. This is possibly due to axon regeneration inside our platform. To verify the tissue response of our electrodes to the sciatic nerve, we performed immunohistochemistry (IHC) and observed axon regeneration without scar tissue forming inside the conduit. Thus, our strategy has proven that our neural interface can play a significant role in the long-term monitoring of the peripheral nerve signal. MDPI 2019-03-13 /pmc/articles/PMC6471311/ /pubmed/30871203 http://dx.doi.org/10.3390/mi10030184 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jung, Woohyun
Jung, Sunyoung
Kim, Ockchul
Park, HyungDal
Choi, Wonsuk
Son, Donghee
Chung, Seok
Kim, Jinseok
Wire Electrodes Embedded in Artificial Conduit for Long-term Monitoring of the Peripheral Nerve Signal
title Wire Electrodes Embedded in Artificial Conduit for Long-term Monitoring of the Peripheral Nerve Signal
title_full Wire Electrodes Embedded in Artificial Conduit for Long-term Monitoring of the Peripheral Nerve Signal
title_fullStr Wire Electrodes Embedded in Artificial Conduit for Long-term Monitoring of the Peripheral Nerve Signal
title_full_unstemmed Wire Electrodes Embedded in Artificial Conduit for Long-term Monitoring of the Peripheral Nerve Signal
title_short Wire Electrodes Embedded in Artificial Conduit for Long-term Monitoring of the Peripheral Nerve Signal
title_sort wire electrodes embedded in artificial conduit for long-term monitoring of the peripheral nerve signal
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471311/
https://www.ncbi.nlm.nih.gov/pubmed/30871203
http://dx.doi.org/10.3390/mi10030184
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