Cargando…

Amyloid-Targeting PET Tracer [(18)F]Flutemetamol Accumulates in Atherosclerotic Plaques

Atherosclerosis is characterized by the accumulation of oxidized lipids in the artery wall, which triggers an inflammatory response. Oxidized low-density lipoprotein (ox-LDL) presents amyloid-like structural properties, and different amyloid species have recently been recognized in atherosclerotic p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hellberg, Sanna, Silvola, Johanna M.U., Liljenbäck, Heidi, Kiugel, Max, Eskola, Olli, Hakovirta, Harri, Hörkkö, Sohvi, Morisson-Iveson, Veronique, Hirani, Ella, Saukko, Pekka, Ylä-Herttuala, Seppo, Knuuti, Juhani, Saraste, Antti, Roivainen, Anne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471324/ https://www.ncbi.nlm.nih.gov/pubmed/30893771 http://dx.doi.org/10.3390/molecules24061072

Ejemplares similares

Positron Emission Tomography Imaging of Macrophages in Atherosclerosis with (18)F-GE-180, a Radiotracer for Translocator Protein (TSPO)
por: Hellberg, Sanna, et al.
Publicado: (2018)

Type 2 diabetes enhances arterial uptake of choline in atherosclerotic mice: an imaging study with positron emission tomography tracer (18)F-fluoromethylcholine
por: Hellberg, Sanna, et al.
Publicado: (2016)

Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaques
por: Silvola, Johanna M. U., et al.
Publicado: (2016)

Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography
por: Silvola, Johanna M. U., et al.
Publicado: (2018)

Evaluation of [(68)Ga]Ga-DOTA-TCTP-1 for the Detection of Metalloproteinase 2/9 Expression in Mouse Atherosclerotic Plaques
por: Kiugel, Max, et al.
Publicado: (2018)

Glucagon-like peptide-1 receptor expression after myocardial infarction: Imaging study using (68)Ga-NODAGA-exendin-4 positron emission tomography
por: Ståhle, Mia, et al.
Publicado: (2018)

Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular (18)F-FDG Uptake in Atherosclerotic Mice
por: Ståhle, Mia, et al.
Publicado: (2020)

Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-(18)F-Fluoroglutamine
por: Palani, Senthil, et al.
Publicado: (2022)

Corrigendum: Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-(18)F-Fluoroglutamine
por: Palani, Senthil, et al.
Publicado: (2022)

(68)Ga-DOTA chelate, a novel imaging agent for assessment of myocardial perfusion and infarction detection in a rodent model
por: Autio, Anu, et al.
Publicado: (2019)

Uptake of (68)gallium in atherosclerotic plaques in LDLR(-/-)ApoB(100/100 )mice
por: Silvola, Johanna MU, et al.
Publicado: (2011)

Imaging of α(v)β(3) integrin expression in experimental myocardial ischemia with [(68)Ga]NODAGA-RGD positron emission tomography
por: Grönman, Maria, et al.
Publicado: (2017)

Evaluation of [(68)Ga]Ga-NODAGA-RGD for PET Imaging of Rat Autoimmune Myocarditis
por: Jahandideh, Arghavan, et al.
Publicado: (2021)

Lipid accumulation, lipid oxidation, and low plasma levels of acquired antibodies against oxidized lipids associate with degeneration and rupture of the intracranial aneurysm wall
por: Frösen, Juhana, et al.
Publicado: (2013)

Comparison of (68)Ga-DOTA-Siglec-9 and (18)F-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry
por: Virtanen, Helena, et al.
Publicado: (2017)

Assessment of myocardial viability with [(15)O]water PET: A validation study in experimental myocardial infarction
por: Grönman, Maria, et al.
Publicado: (2019)

Association between [(68)Ga]NODAGA-RGDyK uptake and dynamics of angiogenesis in a human cell-based 3D model
por: Grönman, Maria, et al.
Publicado: (2021)

Vascular adhesion protein-1-targeted PET imaging in autoimmune myocarditis
por: Jahandideh, Arghavan, et al.
Publicado: (2023)

Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis
por: Elo, Petri, et al.
Publicado: (2021)

ESC 2019 guidelines for the diagnosis and management of chronic coronary syndromes: Recommendations for cardiovascular imaging
por: Saraste, Antti, et al.
Publicado: (2020)

Adenoviral intramyocardial VEGF-D(ΔNΔC) gene transfer increases myocardial perfusion reserve in refractory angina patients: a phase I/IIa study with 1-year follow-up
por: Hartikainen, Juha, et al.
Publicado: (2017)

AAV2-VEGF-B gene therapy failed to induce angiogenesis in ischemic porcine myocardium due to inflammatory responses
por: Korpela, Henna, et al.
Publicado: (2022)

[(18)F]FDG Accumulation in Early Coronary Atherosclerotic Lesions in Pigs
por: Tarkia, Miikka, et al.
Publicado: (2015)

Adventures in radiosynthesis of clinical grade [(68)Ga]Ga-DOTA-Siglec-9
por: Käkelä, Meeri, et al.
Publicado: (2018)

Phenotyping heart failure by nuclear imaging of myocardial perfusion, metabolism, and molecular targets
por: Saraste, Antti, et al.
Publicado: (2023)

Gene Therapy Used in Cancer Treatment
por: Wirth, Thomas, et al.
Publicado: (2014)

Therapeutic Potential of VEGF-B in Coronary Heart Disease and Heart Failure: Dream or Vision?
por: Mallick, Rahul, et al.
Publicado: (2022)

Lymphatic insufficiency leads to distinct myocardial infarct content assessed by magnetic resonance T(RAFFn), T(1ρ) and T(2) relaxation times
por: Ylä-Herttuala, Elias, et al.
Publicado: (2023)

Circulating N-terminal brain natriuretic peptide and cardiac function in response to acute systemic hypoxia in healthy humans
por: Heinonen, Ilkka, et al.
Publicado: (2014)

Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction
por: Vuorio, Taina, et al.
Publicado: (2018)

Quantification of porcine myocardial perfusion with modified dual bolus MRI – a prospective study with a PET reference
por: Husso, Minna, et al.
Publicado: (2019)

Promoting blood vessel growth in ischemic diseases: challenges in translating preclinical potential into clinical success
por: Dragneva, Galina, et al.
Publicado: (2013)

Dotted collar placed around carotid artery induces asymmetric neointimal lesion formation in rabbits without intravascular manipulations
por: Kivelä, Antti, et al.
Publicado: (2012)

Characterization of a new IN-I-PpoI fusion protein and a homology-arm containing transgene cassette that improve transgene expression persistence and 28S rRNA gene-targeted insertion of lentiviral vectors
por: Nousiainen, Alisa, et al.
Publicado: (2023)

In vivo PET imaging of beta-amyloid deposition in mouse models of Alzheimer's disease with a high specific activity PET imaging agent [(18)F]flutemetamol
por: Snellman, Anniina, et al.
Publicado: (2014)

Radiosynthesis and preclinical evaluation of [(68)Ga]Ga-NOTA-folate for PET imaging of folate receptor β-positive macrophages
por: Moisio, Olli, et al.
Publicado: (2020)

(18)F-FDG positron emission tomography/computed tomography of cardiac implantable electronic device infections
por: Salomäki, Soile Pauliina, et al.
Publicado: (2020)

A New Gene Therapy Approach for Cardiovascular Disease by Non-coding RNAs Acting in the Nucleus
por: Husso, Tiia, et al.
Publicado: (2014)

Nucleic Acid–Based Therapies for Atherosclerosis
por: Mäkinen, Petri, et al.
Publicado: (2020)

Novel RNAi-Based Therapies for Atherosclerosis
por: Ruotsalainen, Anna-Kaisa, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_fmrsb0mlas8cpnbj0ers5s7i5r