Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of Heptaptera anatolica

Seven known sesquiterpene coumarins and a new sesquiterpene coumarin, anatolicin (8), were isolated from the dichloromethane extract of the roots of Heptaptera anatolica. Structures of these compounds were elucidated based on their spectral properties. While some of these sesquiterpene coumarins sho...

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Autores principales: Tosun, Fatma, Beutler, John A., Ransom, Tanya T., Miski, Mahmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471333/
https://www.ncbi.nlm.nih.gov/pubmed/30909537
http://dx.doi.org/10.3390/molecules24061153
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author Tosun, Fatma
Beutler, John A.
Ransom, Tanya T.
Miski, Mahmut
author_facet Tosun, Fatma
Beutler, John A.
Ransom, Tanya T.
Miski, Mahmut
author_sort Tosun, Fatma
collection PubMed
description Seven known sesquiterpene coumarins and a new sesquiterpene coumarin, anatolicin (8), were isolated from the dichloromethane extract of the roots of Heptaptera anatolica. Structures of these compounds were elucidated based on their spectral properties. While some of these sesquiterpene coumarins showed modest cytotoxic activity against COLO205, KM12, A498, UO31, and TC32 cancer cell lines, selective cytotoxicity of anatolicin (8) and 14′-acetoxybadrakemin (7) were observed at nanomolar level against the UO31 kidney cancer cell line.
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spelling pubmed-64713332019-04-26 Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of Heptaptera anatolica Tosun, Fatma Beutler, John A. Ransom, Tanya T. Miski, Mahmut Molecules Article Seven known sesquiterpene coumarins and a new sesquiterpene coumarin, anatolicin (8), were isolated from the dichloromethane extract of the roots of Heptaptera anatolica. Structures of these compounds were elucidated based on their spectral properties. While some of these sesquiterpene coumarins showed modest cytotoxic activity against COLO205, KM12, A498, UO31, and TC32 cancer cell lines, selective cytotoxicity of anatolicin (8) and 14′-acetoxybadrakemin (7) were observed at nanomolar level against the UO31 kidney cancer cell line. MDPI 2019-03-23 /pmc/articles/PMC6471333/ /pubmed/30909537 http://dx.doi.org/10.3390/molecules24061153 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tosun, Fatma
Beutler, John A.
Ransom, Tanya T.
Miski, Mahmut
Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of Heptaptera anatolica
title Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of Heptaptera anatolica
title_full Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of Heptaptera anatolica
title_fullStr Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of Heptaptera anatolica
title_full_unstemmed Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of Heptaptera anatolica
title_short Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of Heptaptera anatolica
title_sort anatolicin, a highly potent and selective cytotoxic sesquiterpene coumarin from the root extract of heptaptera anatolica
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471333/
https://www.ncbi.nlm.nih.gov/pubmed/30909537
http://dx.doi.org/10.3390/molecules24061153
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