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Parametric Modeling of Biomimetic Cortical Bone Microstructure for Additive Manufacturing

In this work we present a novel algorithm for generating in-silico biomimetic models of a cortical bone microstructure towards manufacturing biomimetic bone via additive manufacturing. The software provides a tool for physicians or biomedical engineers to develop models of cortical bone that include...

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Autores principales: Robles-Linares, José A., Ramírez-Cedillo, Erick, Siller, Hector R., Rodríguez, Ciro A., Martínez-López, J. Israel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471362/
https://www.ncbi.nlm.nih.gov/pubmed/30893894
http://dx.doi.org/10.3390/ma12060913
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author Robles-Linares, José A.
Ramírez-Cedillo, Erick
Siller, Hector R.
Rodríguez, Ciro A.
Martínez-López, J. Israel
author_facet Robles-Linares, José A.
Ramírez-Cedillo, Erick
Siller, Hector R.
Rodríguez, Ciro A.
Martínez-López, J. Israel
author_sort Robles-Linares, José A.
collection PubMed
description In this work we present a novel algorithm for generating in-silico biomimetic models of a cortical bone microstructure towards manufacturing biomimetic bone via additive manufacturing. The software provides a tool for physicians or biomedical engineers to develop models of cortical bone that include the inherent complexity of the microstructure. The correspondence of the produced virtual prototypes with natural bone tissue was assessed experimentally employing Digital Light Processing (DLP) of a thermoset polymer resin to recreate healthy and osteoporotic bone tissue microstructure. The proposed tool was successfully implemented to develop cortical bone structure based on osteon density, cement line thickness, and the Haversian and Volkmann channels to produce a user-designated bone porosity that matches within values reported from literature for these types of tissues. Characterization of the specimens using a Scanning Electron Microscopy with Focused Ion Beam (SEM/FIB) and Computer Tomography (CT) revealed that the manufacturability of intricated virtual prototype is possible for scaled-up versions of the tissue. Modeling based on the density, inclination and size range of the osteon and Haversian and Volkmann´s canals granted the development of a dynamic in-silico porosity (13.37–21.49%) that matches with models of healthy and osteoporotic bone. Correspondence of the designed porosity with the manufactured assessment (5.79–16.16%) shows that the introduced methodology is a step towards the development of more refined and lifelike porous structures such as cortical bone. Further research is required for validation of the proposed methodology model of the real bone tissue and as a patient-specific customization tool of synthetic bone.
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spelling pubmed-64713622019-04-27 Parametric Modeling of Biomimetic Cortical Bone Microstructure for Additive Manufacturing Robles-Linares, José A. Ramírez-Cedillo, Erick Siller, Hector R. Rodríguez, Ciro A. Martínez-López, J. Israel Materials (Basel) Article In this work we present a novel algorithm for generating in-silico biomimetic models of a cortical bone microstructure towards manufacturing biomimetic bone via additive manufacturing. The software provides a tool for physicians or biomedical engineers to develop models of cortical bone that include the inherent complexity of the microstructure. The correspondence of the produced virtual prototypes with natural bone tissue was assessed experimentally employing Digital Light Processing (DLP) of a thermoset polymer resin to recreate healthy and osteoporotic bone tissue microstructure. The proposed tool was successfully implemented to develop cortical bone structure based on osteon density, cement line thickness, and the Haversian and Volkmann channels to produce a user-designated bone porosity that matches within values reported from literature for these types of tissues. Characterization of the specimens using a Scanning Electron Microscopy with Focused Ion Beam (SEM/FIB) and Computer Tomography (CT) revealed that the manufacturability of intricated virtual prototype is possible for scaled-up versions of the tissue. Modeling based on the density, inclination and size range of the osteon and Haversian and Volkmann´s canals granted the development of a dynamic in-silico porosity (13.37–21.49%) that matches with models of healthy and osteoporotic bone. Correspondence of the designed porosity with the manufactured assessment (5.79–16.16%) shows that the introduced methodology is a step towards the development of more refined and lifelike porous structures such as cortical bone. Further research is required for validation of the proposed methodology model of the real bone tissue and as a patient-specific customization tool of synthetic bone. MDPI 2019-03-19 /pmc/articles/PMC6471362/ /pubmed/30893894 http://dx.doi.org/10.3390/ma12060913 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Robles-Linares, José A.
Ramírez-Cedillo, Erick
Siller, Hector R.
Rodríguez, Ciro A.
Martínez-López, J. Israel
Parametric Modeling of Biomimetic Cortical Bone Microstructure for Additive Manufacturing
title Parametric Modeling of Biomimetic Cortical Bone Microstructure for Additive Manufacturing
title_full Parametric Modeling of Biomimetic Cortical Bone Microstructure for Additive Manufacturing
title_fullStr Parametric Modeling of Biomimetic Cortical Bone Microstructure for Additive Manufacturing
title_full_unstemmed Parametric Modeling of Biomimetic Cortical Bone Microstructure for Additive Manufacturing
title_short Parametric Modeling of Biomimetic Cortical Bone Microstructure for Additive Manufacturing
title_sort parametric modeling of biomimetic cortical bone microstructure for additive manufacturing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471362/
https://www.ncbi.nlm.nih.gov/pubmed/30893894
http://dx.doi.org/10.3390/ma12060913
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