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Two-step Synthesis of Solasodine Pivalate from Diosgenin Pivalate

A two-step synthesis of solasodine pivalate from diosgenin pivalate is described. The key transformation involves the reaction of diosgenin pivalate with benzyl carbamate (CbzNH(2)) promoted by TMSOTf. During the reaction the F-ring of the spiroketal moiety opens up with a simultaneous introduction...

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Detalles Bibliográficos
Autores principales:	Wojtkielewicz, Agnieszka, Kiełczewska, Urszula, Morzycki, Jacek W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471385/ https://www.ncbi.nlm.nih.gov/pubmed/30901960 http://dx.doi.org/10.3390/molecules24061132

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