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A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice

In our previous studies, a standardized phlorotannin (brown seaweed polyphenol) supplement (PS) exhibited sleep-promoting effects via type A γ-aminobutyric acid-benzodiazepine receptors in mice. In addition, in human clinical trials, it decreased wake after sleep onset in adults with sleep disturban...

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Autores principales: Kwon, Sangoh, Yoon, Minseok, Lee, Jaekwang, Moon, Kwang-Deog, Kim, Dohyeon, Kim, Seon-Bong, Cho, Suengmok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471389/
https://www.ncbi.nlm.nih.gov/pubmed/30845636
http://dx.doi.org/10.3390/nu11030556
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author Kwon, Sangoh
Yoon, Minseok
Lee, Jaekwang
Moon, Kwang-Deog
Kim, Dohyeon
Kim, Seon-Bong
Cho, Suengmok
author_facet Kwon, Sangoh
Yoon, Minseok
Lee, Jaekwang
Moon, Kwang-Deog
Kim, Dohyeon
Kim, Seon-Bong
Cho, Suengmok
author_sort Kwon, Sangoh
collection PubMed
description In our previous studies, a standardized phlorotannin (brown seaweed polyphenol) supplement (PS) exhibited sleep-promoting effects via type A γ-aminobutyric acid-benzodiazepine receptors in mice. In addition, in human clinical trials, it decreased wake after sleep onset in adults with sleep disturbance. In this follow-up study, we investigated whether PS attenuates caffeine-induced sleep disruption in mice. The effects of PS were evaluated in a caffeine model by analyzing sleep architecture based on electroencephalogram and electromyogram findings, and were compared with the effects of a well-known sedative-hypnotic drug zolpidem (ZPD). As expected, oral administration of caffeine (25 mg/kg) significantly increased sleep latency and decreased the amount of non-rapid eye movement sleep (NREMS). In the caffeine + PS and caffeine + ZPD groups, PS (500 mg/kg) attenuated caffeine-induced sleep disruption, and its effects were comparable with those of ZPD (10 mg/kg). In particular, PS inhibited the arousal effects of caffeine without change in delta activity during NREMS, whereas ZPD produced a decrease in the delta activity. Considering global trends in coffee and energy drink consumption, our finding suggest that PS may be useful to relieve transitory insomnia symptoms caused by caffeine consumption, unlike the prescription drug ZPD.
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spelling pubmed-64713892019-04-25 A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice Kwon, Sangoh Yoon, Minseok Lee, Jaekwang Moon, Kwang-Deog Kim, Dohyeon Kim, Seon-Bong Cho, Suengmok Nutrients Article In our previous studies, a standardized phlorotannin (brown seaweed polyphenol) supplement (PS) exhibited sleep-promoting effects via type A γ-aminobutyric acid-benzodiazepine receptors in mice. In addition, in human clinical trials, it decreased wake after sleep onset in adults with sleep disturbance. In this follow-up study, we investigated whether PS attenuates caffeine-induced sleep disruption in mice. The effects of PS were evaluated in a caffeine model by analyzing sleep architecture based on electroencephalogram and electromyogram findings, and were compared with the effects of a well-known sedative-hypnotic drug zolpidem (ZPD). As expected, oral administration of caffeine (25 mg/kg) significantly increased sleep latency and decreased the amount of non-rapid eye movement sleep (NREMS). In the caffeine + PS and caffeine + ZPD groups, PS (500 mg/kg) attenuated caffeine-induced sleep disruption, and its effects were comparable with those of ZPD (10 mg/kg). In particular, PS inhibited the arousal effects of caffeine without change in delta activity during NREMS, whereas ZPD produced a decrease in the delta activity. Considering global trends in coffee and energy drink consumption, our finding suggest that PS may be useful to relieve transitory insomnia symptoms caused by caffeine consumption, unlike the prescription drug ZPD. MDPI 2019-03-06 /pmc/articles/PMC6471389/ /pubmed/30845636 http://dx.doi.org/10.3390/nu11030556 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kwon, Sangoh
Yoon, Minseok
Lee, Jaekwang
Moon, Kwang-Deog
Kim, Dohyeon
Kim, Seon-Bong
Cho, Suengmok
A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice
title A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice
title_full A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice
title_fullStr A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice
title_full_unstemmed A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice
title_short A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice
title_sort standardized phlorotannin supplement attenuates caffeine-induced sleep disruption in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471389/
https://www.ncbi.nlm.nih.gov/pubmed/30845636
http://dx.doi.org/10.3390/nu11030556
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