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A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice
In our previous studies, a standardized phlorotannin (brown seaweed polyphenol) supplement (PS) exhibited sleep-promoting effects via type A γ-aminobutyric acid-benzodiazepine receptors in mice. In addition, in human clinical trials, it decreased wake after sleep onset in adults with sleep disturban...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471389/ https://www.ncbi.nlm.nih.gov/pubmed/30845636 http://dx.doi.org/10.3390/nu11030556 |
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author | Kwon, Sangoh Yoon, Minseok Lee, Jaekwang Moon, Kwang-Deog Kim, Dohyeon Kim, Seon-Bong Cho, Suengmok |
author_facet | Kwon, Sangoh Yoon, Minseok Lee, Jaekwang Moon, Kwang-Deog Kim, Dohyeon Kim, Seon-Bong Cho, Suengmok |
author_sort | Kwon, Sangoh |
collection | PubMed |
description | In our previous studies, a standardized phlorotannin (brown seaweed polyphenol) supplement (PS) exhibited sleep-promoting effects via type A γ-aminobutyric acid-benzodiazepine receptors in mice. In addition, in human clinical trials, it decreased wake after sleep onset in adults with sleep disturbance. In this follow-up study, we investigated whether PS attenuates caffeine-induced sleep disruption in mice. The effects of PS were evaluated in a caffeine model by analyzing sleep architecture based on electroencephalogram and electromyogram findings, and were compared with the effects of a well-known sedative-hypnotic drug zolpidem (ZPD). As expected, oral administration of caffeine (25 mg/kg) significantly increased sleep latency and decreased the amount of non-rapid eye movement sleep (NREMS). In the caffeine + PS and caffeine + ZPD groups, PS (500 mg/kg) attenuated caffeine-induced sleep disruption, and its effects were comparable with those of ZPD (10 mg/kg). In particular, PS inhibited the arousal effects of caffeine without change in delta activity during NREMS, whereas ZPD produced a decrease in the delta activity. Considering global trends in coffee and energy drink consumption, our finding suggest that PS may be useful to relieve transitory insomnia symptoms caused by caffeine consumption, unlike the prescription drug ZPD. |
format | Online Article Text |
id | pubmed-6471389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64713892019-04-25 A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice Kwon, Sangoh Yoon, Minseok Lee, Jaekwang Moon, Kwang-Deog Kim, Dohyeon Kim, Seon-Bong Cho, Suengmok Nutrients Article In our previous studies, a standardized phlorotannin (brown seaweed polyphenol) supplement (PS) exhibited sleep-promoting effects via type A γ-aminobutyric acid-benzodiazepine receptors in mice. In addition, in human clinical trials, it decreased wake after sleep onset in adults with sleep disturbance. In this follow-up study, we investigated whether PS attenuates caffeine-induced sleep disruption in mice. The effects of PS were evaluated in a caffeine model by analyzing sleep architecture based on electroencephalogram and electromyogram findings, and were compared with the effects of a well-known sedative-hypnotic drug zolpidem (ZPD). As expected, oral administration of caffeine (25 mg/kg) significantly increased sleep latency and decreased the amount of non-rapid eye movement sleep (NREMS). In the caffeine + PS and caffeine + ZPD groups, PS (500 mg/kg) attenuated caffeine-induced sleep disruption, and its effects were comparable with those of ZPD (10 mg/kg). In particular, PS inhibited the arousal effects of caffeine without change in delta activity during NREMS, whereas ZPD produced a decrease in the delta activity. Considering global trends in coffee and energy drink consumption, our finding suggest that PS may be useful to relieve transitory insomnia symptoms caused by caffeine consumption, unlike the prescription drug ZPD. MDPI 2019-03-06 /pmc/articles/PMC6471389/ /pubmed/30845636 http://dx.doi.org/10.3390/nu11030556 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kwon, Sangoh Yoon, Minseok Lee, Jaekwang Moon, Kwang-Deog Kim, Dohyeon Kim, Seon-Bong Cho, Suengmok A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice |
title | A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice |
title_full | A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice |
title_fullStr | A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice |
title_full_unstemmed | A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice |
title_short | A Standardized Phlorotannin Supplement Attenuates Caffeine-Induced Sleep Disruption in Mice |
title_sort | standardized phlorotannin supplement attenuates caffeine-induced sleep disruption in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471389/ https://www.ncbi.nlm.nih.gov/pubmed/30845636 http://dx.doi.org/10.3390/nu11030556 |
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