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Pregnancy Loss and Iodine Status: The LIFE Prospective Cohort Study

Iodine deficiency in pregnancy is a common problem in the United States and parts of Europe, but whether iodine deficiency is associated with increased pregnancy loss has not been well studied. The LIFE study provided an excellent opportunity to examine the relationship between iodine status and pre...

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Autores principales: Mills, James L., Ali, Mehnaz, Buck Louis, Germaine M., Kannan, Kurunthachalam, Weck, Jennifer, Wan, Yanjian, Maisog, Joe, Giannakou, Andreas, Sundaram, Rajeshwari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471412/
https://www.ncbi.nlm.nih.gov/pubmed/30823683
http://dx.doi.org/10.3390/nu11030534
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author Mills, James L.
Ali, Mehnaz
Buck Louis, Germaine M.
Kannan, Kurunthachalam
Weck, Jennifer
Wan, Yanjian
Maisog, Joe
Giannakou, Andreas
Sundaram, Rajeshwari
author_facet Mills, James L.
Ali, Mehnaz
Buck Louis, Germaine M.
Kannan, Kurunthachalam
Weck, Jennifer
Wan, Yanjian
Maisog, Joe
Giannakou, Andreas
Sundaram, Rajeshwari
author_sort Mills, James L.
collection PubMed
description Iodine deficiency in pregnancy is a common problem in the United States and parts of Europe, but whether iodine deficiency is associated with increased pregnancy loss has not been well studied. The LIFE study provided an excellent opportunity to examine the relationship between iodine status and pregnancy loss because women were monitored prospectively to ensure excellent ascertainment of conceptions. The LIFE study, a population-based prospective cohort study, monitored 501 women who had discontinued contraception within two months to become pregnant; 329 became pregnant, had urinary iodine concentrations measured on samples collected at enrollment, and were followed up to determine pregnancy outcomes. Of the 329, 196 had live births (59.5%), 92 (28.0%) had losses, and 41 (12.5%) withdrew or were lost to follow up. Urinary iodine concentrations were in the deficiency range in 59.6% of the participants. The risk of loss, however, was not elevated in the mildly deficient group (hazard ratio 0.69, 95% confidence interval 0.34, 1.38), the moderately deficient group (hazard ratio 0.81, 95% confidence interval 0.43, 1.51), or the severely deficient group (hazard ratio 0.69, 95% confidence interval 0.32, 1.50). Iodine deficiency, even when moderate to severe, was not associated with increased rates of pregnancy loss. This study provides some reassurance that iodine deficiency at levels seen in many developed countries does not increase the risk of pregnancy loss.
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spelling pubmed-64714122019-04-25 Pregnancy Loss and Iodine Status: The LIFE Prospective Cohort Study Mills, James L. Ali, Mehnaz Buck Louis, Germaine M. Kannan, Kurunthachalam Weck, Jennifer Wan, Yanjian Maisog, Joe Giannakou, Andreas Sundaram, Rajeshwari Nutrients Article Iodine deficiency in pregnancy is a common problem in the United States and parts of Europe, but whether iodine deficiency is associated with increased pregnancy loss has not been well studied. The LIFE study provided an excellent opportunity to examine the relationship between iodine status and pregnancy loss because women were monitored prospectively to ensure excellent ascertainment of conceptions. The LIFE study, a population-based prospective cohort study, monitored 501 women who had discontinued contraception within two months to become pregnant; 329 became pregnant, had urinary iodine concentrations measured on samples collected at enrollment, and were followed up to determine pregnancy outcomes. Of the 329, 196 had live births (59.5%), 92 (28.0%) had losses, and 41 (12.5%) withdrew or were lost to follow up. Urinary iodine concentrations were in the deficiency range in 59.6% of the participants. The risk of loss, however, was not elevated in the mildly deficient group (hazard ratio 0.69, 95% confidence interval 0.34, 1.38), the moderately deficient group (hazard ratio 0.81, 95% confidence interval 0.43, 1.51), or the severely deficient group (hazard ratio 0.69, 95% confidence interval 0.32, 1.50). Iodine deficiency, even when moderate to severe, was not associated with increased rates of pregnancy loss. This study provides some reassurance that iodine deficiency at levels seen in many developed countries does not increase the risk of pregnancy loss. MDPI 2019-03-01 /pmc/articles/PMC6471412/ /pubmed/30823683 http://dx.doi.org/10.3390/nu11030534 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mills, James L.
Ali, Mehnaz
Buck Louis, Germaine M.
Kannan, Kurunthachalam
Weck, Jennifer
Wan, Yanjian
Maisog, Joe
Giannakou, Andreas
Sundaram, Rajeshwari
Pregnancy Loss and Iodine Status: The LIFE Prospective Cohort Study
title Pregnancy Loss and Iodine Status: The LIFE Prospective Cohort Study
title_full Pregnancy Loss and Iodine Status: The LIFE Prospective Cohort Study
title_fullStr Pregnancy Loss and Iodine Status: The LIFE Prospective Cohort Study
title_full_unstemmed Pregnancy Loss and Iodine Status: The LIFE Prospective Cohort Study
title_short Pregnancy Loss and Iodine Status: The LIFE Prospective Cohort Study
title_sort pregnancy loss and iodine status: the life prospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471412/
https://www.ncbi.nlm.nih.gov/pubmed/30823683
http://dx.doi.org/10.3390/nu11030534
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