Performance Evaluation of Miniature Integrated Electrochemical Cells Fabricated Using LTCC Technology †

Miniaturized and integrated analytical devices, including chemical sensors, are at the forefront of modern analytical chemistry. The construction of novel analytical tools takes advantage of contemporary micro- and nanotechnologies, as well as materials science and technology. Two electrochemical techniques were used in experiments: electrochemical impedance spectroscopy and cyclic voltammetry. The goal of this study was to investigate electron transfer resistance in a model solution containing [Formula: see text] ions and protein adsorption using integrated electrochemical cells with different geometry. Tests performed at various [Formula: see text] concentration allowed to verify that these cells work properly. The influence of bovine serum albumin adsorbing to the surface of the integrated electrochemical cells was investigated. In electrochemical impedance spectroscopy, the value of [Formula: see text] increased with protein adsorption and the relative change of [Formula: see text] was in range 21% to 55%. In cyclic voltammetry the decreasing amperometric response of the working electrode was used as evidence of protein adsorption on the electrode.