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Obesity Is Associated with Changes in Iron Nutrition Status and Its Homeostatic Regulation in Pregnancy

The influence of obesity on maternal iron homeostasis and nutrition status during pregnancy remains only partially clarified. Our study objectives were (1) to describe how obesity influences broad iron nutrition spectrum biomarkers such as available or circulating iron (serum transferrin receptor (s...

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Autores principales: Flores-Quijano, María Eugenia, Vega-Sánchez, Rodrigo, Tolentino-Dolores, Mari Cruz, López-Alarcón, Mardia Guadalupe, Flores-Urrutia, Mónica Crissel, López-Olvera, Ana Daniela, Talavera, Juan O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471435/
https://www.ncbi.nlm.nih.gov/pubmed/30909605
http://dx.doi.org/10.3390/nu11030693
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author Flores-Quijano, María Eugenia
Vega-Sánchez, Rodrigo
Tolentino-Dolores, Mari Cruz
López-Alarcón, Mardia Guadalupe
Flores-Urrutia, Mónica Crissel
López-Olvera, Ana Daniela
Talavera, Juan O
author_facet Flores-Quijano, María Eugenia
Vega-Sánchez, Rodrigo
Tolentino-Dolores, Mari Cruz
López-Alarcón, Mardia Guadalupe
Flores-Urrutia, Mónica Crissel
López-Olvera, Ana Daniela
Talavera, Juan O
author_sort Flores-Quijano, María Eugenia
collection PubMed
description The influence of obesity on maternal iron homeostasis and nutrition status during pregnancy remains only partially clarified. Our study objectives were (1) to describe how obesity influences broad iron nutrition spectrum biomarkers such as available or circulating iron (serum transferrin receptor (sTfr) and serum iron), iron reserves (ferritin), and functional iron (hemoglobin); and (2) to depict the regulating role of hepcidin. The above was carried out while considering influential factors such as initial iron nutrition status, iron intake, and the presence of inflammation. Ninety three non-anemic pregnant adult women were included, 40 with obesity (Ob) and 53 with adequate weight (AW); all took ≈30 mg/day of supplementary iron. Information on iron intake and blood samples were obtained at gestational weeks 13, 20, 27, and 35. A series of repeated measure analyses were performed using General Linear Models to discern the effect of obesity on each iron indicator; iron intake, hepcidin, and C-reactive protein were successively introduced as covariates. Available and circulating iron was lower in obese women: sTfr was higher (p = 0.07) and serum iron was lower (p = 0.01); and ferritin and hemoglobin were not different between groups. Hepcidin was higher in the Ob group (p = 0.01) and was a significant predictor variable for all biomarkers. Obesity during pregnancy dysregulates iron homeostasis, resembling “obesity hypoferremia”.
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spelling pubmed-64714352019-04-25 Obesity Is Associated with Changes in Iron Nutrition Status and Its Homeostatic Regulation in Pregnancy Flores-Quijano, María Eugenia Vega-Sánchez, Rodrigo Tolentino-Dolores, Mari Cruz López-Alarcón, Mardia Guadalupe Flores-Urrutia, Mónica Crissel López-Olvera, Ana Daniela Talavera, Juan O Nutrients Article The influence of obesity on maternal iron homeostasis and nutrition status during pregnancy remains only partially clarified. Our study objectives were (1) to describe how obesity influences broad iron nutrition spectrum biomarkers such as available or circulating iron (serum transferrin receptor (sTfr) and serum iron), iron reserves (ferritin), and functional iron (hemoglobin); and (2) to depict the regulating role of hepcidin. The above was carried out while considering influential factors such as initial iron nutrition status, iron intake, and the presence of inflammation. Ninety three non-anemic pregnant adult women were included, 40 with obesity (Ob) and 53 with adequate weight (AW); all took ≈30 mg/day of supplementary iron. Information on iron intake and blood samples were obtained at gestational weeks 13, 20, 27, and 35. A series of repeated measure analyses were performed using General Linear Models to discern the effect of obesity on each iron indicator; iron intake, hepcidin, and C-reactive protein were successively introduced as covariates. Available and circulating iron was lower in obese women: sTfr was higher (p = 0.07) and serum iron was lower (p = 0.01); and ferritin and hemoglobin were not different between groups. Hepcidin was higher in the Ob group (p = 0.01) and was a significant predictor variable for all biomarkers. Obesity during pregnancy dysregulates iron homeostasis, resembling “obesity hypoferremia”. MDPI 2019-03-23 /pmc/articles/PMC6471435/ /pubmed/30909605 http://dx.doi.org/10.3390/nu11030693 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Flores-Quijano, María Eugenia
Vega-Sánchez, Rodrigo
Tolentino-Dolores, Mari Cruz
López-Alarcón, Mardia Guadalupe
Flores-Urrutia, Mónica Crissel
López-Olvera, Ana Daniela
Talavera, Juan O
Obesity Is Associated with Changes in Iron Nutrition Status and Its Homeostatic Regulation in Pregnancy
title Obesity Is Associated with Changes in Iron Nutrition Status and Its Homeostatic Regulation in Pregnancy
title_full Obesity Is Associated with Changes in Iron Nutrition Status and Its Homeostatic Regulation in Pregnancy
title_fullStr Obesity Is Associated with Changes in Iron Nutrition Status and Its Homeostatic Regulation in Pregnancy
title_full_unstemmed Obesity Is Associated with Changes in Iron Nutrition Status and Its Homeostatic Regulation in Pregnancy
title_short Obesity Is Associated with Changes in Iron Nutrition Status and Its Homeostatic Regulation in Pregnancy
title_sort obesity is associated with changes in iron nutrition status and its homeostatic regulation in pregnancy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471435/
https://www.ncbi.nlm.nih.gov/pubmed/30909605
http://dx.doi.org/10.3390/nu11030693
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