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The Toxic Effects and Mechanisms of Nano-Cu on the Spleen of Rats
Research has shown that nano-copper (nano-Cu) can cause damage to the spleen and immune system yet their mechanisms of cytotoxicity are poorly understood. Our aim is to explore the potential immunotoxicity in the spleen of rats after nano-Cu exposure. The results of hematologic parameters, lymphocyt...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471436/ https://www.ncbi.nlm.nih.gov/pubmed/30909528 http://dx.doi.org/10.3390/ijms20061469 |
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author | Zhou, Xuerong Zhao, Ling Luo, Jie Tang, Huaqiao Xu, Min Wang, Yanyan Yang, Xiaoyu Chen, Helin Li, Yinglun Ye, Gang Shi, Fei Lv, Cheng Jing, Bo |
author_facet | Zhou, Xuerong Zhao, Ling Luo, Jie Tang, Huaqiao Xu, Min Wang, Yanyan Yang, Xiaoyu Chen, Helin Li, Yinglun Ye, Gang Shi, Fei Lv, Cheng Jing, Bo |
author_sort | Zhou, Xuerong |
collection | PubMed |
description | Research has shown that nano-copper (nano-Cu) can cause damage to the spleen and immune system yet their mechanisms of cytotoxicity are poorly understood. Our aim is to explore the potential immunotoxicity in the spleen of rats after nano-Cu exposure. The results of hematologic parameters, lymphocyte subsets, immunoglobulins, and histopathology indicated that copper obviously changed the immune function of the spleen. The levels of antioxidants (SOD, CAT, GSH-Px), oxidants (iNOS, NO, MDA), and anti-oxidative signalling pathway of Nrf2 (Nrf2 and HO-1) were strongly induced by nano-Cu. The expression of mRNA and protein of pro-/anti-inflammatory (IFN-γ, TNF-α, MIP-1α, MCP-1, MIF, IL-1/-2/-4/-6) cytokines were increased by nano-Cu. The expression of regulatory signal pathways, MAPKs and PI3-K/Akt were activated, which might be involved in the inflammatory responses and immunomodulatory processes of sub-acute nano-Cu exposure. The immune function of the spleen was repressed by nano-Cu induced oxidative stress and inflammation. |
format | Online Article Text |
id | pubmed-6471436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64714362019-04-26 The Toxic Effects and Mechanisms of Nano-Cu on the Spleen of Rats Zhou, Xuerong Zhao, Ling Luo, Jie Tang, Huaqiao Xu, Min Wang, Yanyan Yang, Xiaoyu Chen, Helin Li, Yinglun Ye, Gang Shi, Fei Lv, Cheng Jing, Bo Int J Mol Sci Article Research has shown that nano-copper (nano-Cu) can cause damage to the spleen and immune system yet their mechanisms of cytotoxicity are poorly understood. Our aim is to explore the potential immunotoxicity in the spleen of rats after nano-Cu exposure. The results of hematologic parameters, lymphocyte subsets, immunoglobulins, and histopathology indicated that copper obviously changed the immune function of the spleen. The levels of antioxidants (SOD, CAT, GSH-Px), oxidants (iNOS, NO, MDA), and anti-oxidative signalling pathway of Nrf2 (Nrf2 and HO-1) were strongly induced by nano-Cu. The expression of mRNA and protein of pro-/anti-inflammatory (IFN-γ, TNF-α, MIP-1α, MCP-1, MIF, IL-1/-2/-4/-6) cytokines were increased by nano-Cu. The expression of regulatory signal pathways, MAPKs and PI3-K/Akt were activated, which might be involved in the inflammatory responses and immunomodulatory processes of sub-acute nano-Cu exposure. The immune function of the spleen was repressed by nano-Cu induced oxidative stress and inflammation. MDPI 2019-03-22 /pmc/articles/PMC6471436/ /pubmed/30909528 http://dx.doi.org/10.3390/ijms20061469 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhou, Xuerong Zhao, Ling Luo, Jie Tang, Huaqiao Xu, Min Wang, Yanyan Yang, Xiaoyu Chen, Helin Li, Yinglun Ye, Gang Shi, Fei Lv, Cheng Jing, Bo The Toxic Effects and Mechanisms of Nano-Cu on the Spleen of Rats |
title | The Toxic Effects and Mechanisms of Nano-Cu on the Spleen of Rats |
title_full | The Toxic Effects and Mechanisms of Nano-Cu on the Spleen of Rats |
title_fullStr | The Toxic Effects and Mechanisms of Nano-Cu on the Spleen of Rats |
title_full_unstemmed | The Toxic Effects and Mechanisms of Nano-Cu on the Spleen of Rats |
title_short | The Toxic Effects and Mechanisms of Nano-Cu on the Spleen of Rats |
title_sort | toxic effects and mechanisms of nano-cu on the spleen of rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471436/ https://www.ncbi.nlm.nih.gov/pubmed/30909528 http://dx.doi.org/10.3390/ijms20061469 |
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