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Polyethylene Glycol: The Future of Posttraumatic Nerve Repair? Systemic Review
Peripheral nerve injury is a common posttraumatic complication. The precise surgical repair of nerve lesion does not always guarantee satisfactory motor and sensory function recovery. Therefore, enhancement of the regeneration process is a subject of many research strategies. It is believed that pol...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471459/ https://www.ncbi.nlm.nih.gov/pubmed/30909624 http://dx.doi.org/10.3390/ijms20061478 |
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author | Paskal, Adriana M. Paskal, Wiktor Pietruski, Piotr Wlodarski, Pawel K. |
author_facet | Paskal, Adriana M. Paskal, Wiktor Pietruski, Piotr Wlodarski, Pawel K. |
author_sort | Paskal, Adriana M. |
collection | PubMed |
description | Peripheral nerve injury is a common posttraumatic complication. The precise surgical repair of nerve lesion does not always guarantee satisfactory motor and sensory function recovery. Therefore, enhancement of the regeneration process is a subject of many research strategies. It is believed that polyethylene glycol (PEG) mediates axolemmal fusion, thus enabling the direct restoration of axon continuity. It also inhibits Wallerian degeneration and recovers nerve conduction. This systemic review, performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, describes and summarizes published studies on PEG treatment efficiency in various nerve injury types and repair techniques. Sixteen original experimental studies in animal models and one in humans were analyzed. PEG treatment superiority was reported in almost all experiments (based on favorable electrophysiological, histological, or behavioral results). To date, only one study attempted to transfer the procedure into the clinical phase. However, some technical aspects, e.g., the maximal delay between trauma and successful treatment, await determination. PEG therapy is a promising prospect that may improve the surgical treatment of peripheral nerve injuries in the clinical practice. |
format | Online Article Text |
id | pubmed-6471459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64714592019-04-26 Polyethylene Glycol: The Future of Posttraumatic Nerve Repair? Systemic Review Paskal, Adriana M. Paskal, Wiktor Pietruski, Piotr Wlodarski, Pawel K. Int J Mol Sci Review Peripheral nerve injury is a common posttraumatic complication. The precise surgical repair of nerve lesion does not always guarantee satisfactory motor and sensory function recovery. Therefore, enhancement of the regeneration process is a subject of many research strategies. It is believed that polyethylene glycol (PEG) mediates axolemmal fusion, thus enabling the direct restoration of axon continuity. It also inhibits Wallerian degeneration and recovers nerve conduction. This systemic review, performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, describes and summarizes published studies on PEG treatment efficiency in various nerve injury types and repair techniques. Sixteen original experimental studies in animal models and one in humans were analyzed. PEG treatment superiority was reported in almost all experiments (based on favorable electrophysiological, histological, or behavioral results). To date, only one study attempted to transfer the procedure into the clinical phase. However, some technical aspects, e.g., the maximal delay between trauma and successful treatment, await determination. PEG therapy is a promising prospect that may improve the surgical treatment of peripheral nerve injuries in the clinical practice. MDPI 2019-03-24 /pmc/articles/PMC6471459/ /pubmed/30909624 http://dx.doi.org/10.3390/ijms20061478 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Paskal, Adriana M. Paskal, Wiktor Pietruski, Piotr Wlodarski, Pawel K. Polyethylene Glycol: The Future of Posttraumatic Nerve Repair? Systemic Review |
title | Polyethylene Glycol: The Future of Posttraumatic Nerve Repair? Systemic Review |
title_full | Polyethylene Glycol: The Future of Posttraumatic Nerve Repair? Systemic Review |
title_fullStr | Polyethylene Glycol: The Future of Posttraumatic Nerve Repair? Systemic Review |
title_full_unstemmed | Polyethylene Glycol: The Future of Posttraumatic Nerve Repair? Systemic Review |
title_short | Polyethylene Glycol: The Future of Posttraumatic Nerve Repair? Systemic Review |
title_sort | polyethylene glycol: the future of posttraumatic nerve repair? systemic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471459/ https://www.ncbi.nlm.nih.gov/pubmed/30909624 http://dx.doi.org/10.3390/ijms20061478 |
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