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Infinite Assembly of Folded Proteins in Evolution, Disease, and Engineering

Mutations and changes in a protein's environment are well known for their potential to induce misfolding and aggregation, including amyloid formation. Alternatively, such perturbations can trigger new interactions that lead to the polymerization of folded proteins. In contrast to aggregation, t...

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Detalles Bibliográficos
Autores principales: Garcia‐Seisdedos, Hector, Villegas, José A., Levy, Emmanuel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471489/
https://www.ncbi.nlm.nih.gov/pubmed/30133878
http://dx.doi.org/10.1002/anie.201806092