Offspring of Mice Exposed to a Low-Protein Diet in Utero Demonstrate Changes in mTOR Signaling in Pancreatic Islets of Langerhans, Associated with Altered Glucagon and Insulin Expression and a Lower β-Cell Mass

Low birth weight is a risk factor for gestational and type 2 diabetes (T2D). Since mammalian target of rapamycin (mTOR) controls pancreatic β-cell mass and hormone release, we hypothesized that nutritional insult in utero might permanently alter mTOR signaling. Mice were fed a low-protein (LP, 8%) o...

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Detalles Bibliográficos
Autores principales: King, Renee, Hill, Jessica L., Saha, Bibek, Tong, Yuzhen, Strutt, Brenda J., Russell, Mark A., Morgan, Noel G., Richardson, Sarah J., Hill, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471519/
https://www.ncbi.nlm.nih.gov/pubmed/30871106
http://dx.doi.org/10.3390/nu11030605

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