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UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca(2+) Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries
Ultraviolet (UV) filters are chemicals widely used in personal care products (PCPs). Due to their effect as endocrine disruptor compounds (EDCs), the toxicity of UV filters is a current concern for human health. EDC exposure may be correlated to cardiovascular diseases (CVD), but to our knowledge, n...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471535/ https://www.ncbi.nlm.nih.gov/pubmed/30893788 http://dx.doi.org/10.3390/ijms20061376 |
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author | Lorigo, Margarida Quintaneiro, Carla Lemos, Manuel C. Martinez-de-Oliveira, José Breitenfeld, Luiza Cairrao, Elisa |
author_facet | Lorigo, Margarida Quintaneiro, Carla Lemos, Manuel C. Martinez-de-Oliveira, José Breitenfeld, Luiza Cairrao, Elisa |
author_sort | Lorigo, Margarida |
collection | PubMed |
description | Ultraviolet (UV) filters are chemicals widely used in personal care products (PCPs). Due to their effect as endocrine disruptor compounds (EDCs), the toxicity of UV filters is a current concern for human health. EDC exposure may be correlated to cardiovascular diseases (CVD), but to our knowledge, no studies assessed the UV filters effects as human EDCs at the vascular level. Octylmethoxycinnamate (OMC) is the world’s most widely used UV-B filter, present in more than 90% of PCPs. Due to its demonstrated multiple hormonal activities in animal models, this substance is also suspected to be a human EDC. The purpose of this study was to assess the rapid/short-term effects of OMC on arterial tonus and analyse its mode of action (MOA). Using human umbilical arteries, the endocrine effects of OMC were evaluated in in vitro (cellular and organ) experiments by planar cell surface area (PCSA) and organ bath, respectively. Our data show that OMC induces a rapid/short-term smooth muscle relaxation acting through an endothelium-independent MOA, which seems to be shared with oestrogens, involving an activation of soluble guanylyl cyclase (sGC) that increases the cyclic guanosine monophosphate (cGMP) intracellular levels and an inhibition of L-type voltage-operated Ca(2+) channels (L-Type VOCC). |
format | Online Article Text |
id | pubmed-6471535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64715352019-04-26 UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca(2+) Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries Lorigo, Margarida Quintaneiro, Carla Lemos, Manuel C. Martinez-de-Oliveira, José Breitenfeld, Luiza Cairrao, Elisa Int J Mol Sci Article Ultraviolet (UV) filters are chemicals widely used in personal care products (PCPs). Due to their effect as endocrine disruptor compounds (EDCs), the toxicity of UV filters is a current concern for human health. EDC exposure may be correlated to cardiovascular diseases (CVD), but to our knowledge, no studies assessed the UV filters effects as human EDCs at the vascular level. Octylmethoxycinnamate (OMC) is the world’s most widely used UV-B filter, present in more than 90% of PCPs. Due to its demonstrated multiple hormonal activities in animal models, this substance is also suspected to be a human EDC. The purpose of this study was to assess the rapid/short-term effects of OMC on arterial tonus and analyse its mode of action (MOA). Using human umbilical arteries, the endocrine effects of OMC were evaluated in in vitro (cellular and organ) experiments by planar cell surface area (PCSA) and organ bath, respectively. Our data show that OMC induces a rapid/short-term smooth muscle relaxation acting through an endothelium-independent MOA, which seems to be shared with oestrogens, involving an activation of soluble guanylyl cyclase (sGC) that increases the cyclic guanosine monophosphate (cGMP) intracellular levels and an inhibition of L-type voltage-operated Ca(2+) channels (L-Type VOCC). MDPI 2019-03-19 /pmc/articles/PMC6471535/ /pubmed/30893788 http://dx.doi.org/10.3390/ijms20061376 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lorigo, Margarida Quintaneiro, Carla Lemos, Manuel C. Martinez-de-Oliveira, José Breitenfeld, Luiza Cairrao, Elisa UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca(2+) Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries |
title | UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca(2+) Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries |
title_full | UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca(2+) Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries |
title_fullStr | UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca(2+) Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries |
title_full_unstemmed | UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca(2+) Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries |
title_short | UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca(2+) Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries |
title_sort | uv-b filter octylmethoxycinnamate induces vasorelaxation by ca(2+) channel inhibition and guanylyl cyclase activation in human umbilical arteries |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471535/ https://www.ncbi.nlm.nih.gov/pubmed/30893788 http://dx.doi.org/10.3390/ijms20061376 |
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