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Distribution of Gadolinium in Rat Heart Studied by Fast Field Cycling Relaxometry and Imaging SIMS
Research on microcirculatory alterations in human heart disease is essential to understand the genesis of myocardial contractile dysfunction and its evolution towards heart failure. The use of contrast agents in magnetic resonance imaging is an important tool in medical diagnostics related to this d...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471734/ https://www.ncbi.nlm.nih.gov/pubmed/30884846 http://dx.doi.org/10.3390/ijms20061339 |
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author | Bonechi, Claudia Consumi, Marco Matteucci, Marco Tamasi, Gabriella Donati, Alessandro Leone, Gemma Menichetti, Luca Kusmic, Claudia Rossi, Claudio Magnani, Agnese |
author_facet | Bonechi, Claudia Consumi, Marco Matteucci, Marco Tamasi, Gabriella Donati, Alessandro Leone, Gemma Menichetti, Luca Kusmic, Claudia Rossi, Claudio Magnani, Agnese |
author_sort | Bonechi, Claudia |
collection | PubMed |
description | Research on microcirculatory alterations in human heart disease is essential to understand the genesis of myocardial contractile dysfunction and its evolution towards heart failure. The use of contrast agents in magnetic resonance imaging is an important tool in medical diagnostics related to this dysfunction. Contrast agents significantly improve the imaging by enhancing the nuclear magnetic relaxation rates of water protons in the tissues where they are distributed. Gadolinium complexes are widely employed in clinical practice due to their high magnetic moment and relatively long electronic relaxation time. In this study, the behavior of gadolinium ion as a contrast agent was investigated by two complementary methods, relaxometry and secondary ion mass spectrometry. The study examined the distribution of blood flow within the microvascular network in ex vivo Langendorff isolated rat heart models, perfused with Omniscan(®) contrast agent. The combined use of secondary ion mass spectrometry and relaxometry allowed for both a qualitative mapping of agent distribution as well as the quantification of gadolinium ion concentration and persistence. This combination of a chemical mapping and temporal analysis of the molar concentration of gadolinium ion in heart tissue allows for new insights on the biomolecular mechanisms underlying the microcirculatory alterations in heart disease. |
format | Online Article Text |
id | pubmed-6471734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64717342019-04-26 Distribution of Gadolinium in Rat Heart Studied by Fast Field Cycling Relaxometry and Imaging SIMS Bonechi, Claudia Consumi, Marco Matteucci, Marco Tamasi, Gabriella Donati, Alessandro Leone, Gemma Menichetti, Luca Kusmic, Claudia Rossi, Claudio Magnani, Agnese Int J Mol Sci Article Research on microcirculatory alterations in human heart disease is essential to understand the genesis of myocardial contractile dysfunction and its evolution towards heart failure. The use of contrast agents in magnetic resonance imaging is an important tool in medical diagnostics related to this dysfunction. Contrast agents significantly improve the imaging by enhancing the nuclear magnetic relaxation rates of water protons in the tissues where they are distributed. Gadolinium complexes are widely employed in clinical practice due to their high magnetic moment and relatively long electronic relaxation time. In this study, the behavior of gadolinium ion as a contrast agent was investigated by two complementary methods, relaxometry and secondary ion mass spectrometry. The study examined the distribution of blood flow within the microvascular network in ex vivo Langendorff isolated rat heart models, perfused with Omniscan(®) contrast agent. The combined use of secondary ion mass spectrometry and relaxometry allowed for both a qualitative mapping of agent distribution as well as the quantification of gadolinium ion concentration and persistence. This combination of a chemical mapping and temporal analysis of the molar concentration of gadolinium ion in heart tissue allows for new insights on the biomolecular mechanisms underlying the microcirculatory alterations in heart disease. MDPI 2019-03-16 /pmc/articles/PMC6471734/ /pubmed/30884846 http://dx.doi.org/10.3390/ijms20061339 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bonechi, Claudia Consumi, Marco Matteucci, Marco Tamasi, Gabriella Donati, Alessandro Leone, Gemma Menichetti, Luca Kusmic, Claudia Rossi, Claudio Magnani, Agnese Distribution of Gadolinium in Rat Heart Studied by Fast Field Cycling Relaxometry and Imaging SIMS |
title | Distribution of Gadolinium in Rat Heart Studied by Fast Field Cycling Relaxometry and Imaging SIMS |
title_full | Distribution of Gadolinium in Rat Heart Studied by Fast Field Cycling Relaxometry and Imaging SIMS |
title_fullStr | Distribution of Gadolinium in Rat Heart Studied by Fast Field Cycling Relaxometry and Imaging SIMS |
title_full_unstemmed | Distribution of Gadolinium in Rat Heart Studied by Fast Field Cycling Relaxometry and Imaging SIMS |
title_short | Distribution of Gadolinium in Rat Heart Studied by Fast Field Cycling Relaxometry and Imaging SIMS |
title_sort | distribution of gadolinium in rat heart studied by fast field cycling relaxometry and imaging sims |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471734/ https://www.ncbi.nlm.nih.gov/pubmed/30884846 http://dx.doi.org/10.3390/ijms20061339 |
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