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Synthesis, In Vitro Antimicrobial and Cytotoxic Activities of Some New Pyrazolo[1,5-a]pyrimidine Derivatives

A new series of pyrazole 4–7 and pyrazolo[1,5-a]pyrimidine 8–13 were synthesized by using a simple, efficient procedure, and screened for their in-vitro antimicrobial and antitumor activities. Symmetrical and asymmetrical 3,6-diarylazo-2,5,7-triaminopyrazolo[1,5-a]pyrimidine were synthesized by the...

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Autores principales: Fouda, Ahmed M., Abbas, Hebat-Allah S., Ahmed, Eman H., Shati, Ali A., Alfaifi, Mohammad Y., Elbehairi, Serag Eldin I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471749/
https://www.ncbi.nlm.nih.gov/pubmed/30893820
http://dx.doi.org/10.3390/molecules24061080
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author Fouda, Ahmed M.
Abbas, Hebat-Allah S.
Ahmed, Eman H.
Shati, Ali A.
Alfaifi, Mohammad Y.
Elbehairi, Serag Eldin I.
author_facet Fouda, Ahmed M.
Abbas, Hebat-Allah S.
Ahmed, Eman H.
Shati, Ali A.
Alfaifi, Mohammad Y.
Elbehairi, Serag Eldin I.
author_sort Fouda, Ahmed M.
collection PubMed
description A new series of pyrazole 4–7 and pyrazolo[1,5-a]pyrimidine 8–13 were synthesized by using a simple, efficient procedure, and screened for their in-vitro antimicrobial and antitumor activities. Symmetrical and asymmetrical 3,6-diarylazo-2,5,7-triaminopyrazolo[1,5-a]pyrimidine were synthesized by the conventional method and also subjected to microwave irradiation and under ultrasound conditions. The biological results revealed that most of the tested compounds proved to be active as antibacterial and antifungal agents. The antitumor activity of the synthesized compounds was evaluated against human cancer cell lines, MCF-7, HCT-116, and HepG-2, as compared with Doxorubicin as a control.
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spelling pubmed-64717492019-04-26 Synthesis, In Vitro Antimicrobial and Cytotoxic Activities of Some New Pyrazolo[1,5-a]pyrimidine Derivatives Fouda, Ahmed M. Abbas, Hebat-Allah S. Ahmed, Eman H. Shati, Ali A. Alfaifi, Mohammad Y. Elbehairi, Serag Eldin I. Molecules Article A new series of pyrazole 4–7 and pyrazolo[1,5-a]pyrimidine 8–13 were synthesized by using a simple, efficient procedure, and screened for their in-vitro antimicrobial and antitumor activities. Symmetrical and asymmetrical 3,6-diarylazo-2,5,7-triaminopyrazolo[1,5-a]pyrimidine were synthesized by the conventional method and also subjected to microwave irradiation and under ultrasound conditions. The biological results revealed that most of the tested compounds proved to be active as antibacterial and antifungal agents. The antitumor activity of the synthesized compounds was evaluated against human cancer cell lines, MCF-7, HCT-116, and HepG-2, as compared with Doxorubicin as a control. MDPI 2019-03-19 /pmc/articles/PMC6471749/ /pubmed/30893820 http://dx.doi.org/10.3390/molecules24061080 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fouda, Ahmed M.
Abbas, Hebat-Allah S.
Ahmed, Eman H.
Shati, Ali A.
Alfaifi, Mohammad Y.
Elbehairi, Serag Eldin I.
Synthesis, In Vitro Antimicrobial and Cytotoxic Activities of Some New Pyrazolo[1,5-a]pyrimidine Derivatives
title Synthesis, In Vitro Antimicrobial and Cytotoxic Activities of Some New Pyrazolo[1,5-a]pyrimidine Derivatives
title_full Synthesis, In Vitro Antimicrobial and Cytotoxic Activities of Some New Pyrazolo[1,5-a]pyrimidine Derivatives
title_fullStr Synthesis, In Vitro Antimicrobial and Cytotoxic Activities of Some New Pyrazolo[1,5-a]pyrimidine Derivatives
title_full_unstemmed Synthesis, In Vitro Antimicrobial and Cytotoxic Activities of Some New Pyrazolo[1,5-a]pyrimidine Derivatives
title_short Synthesis, In Vitro Antimicrobial and Cytotoxic Activities of Some New Pyrazolo[1,5-a]pyrimidine Derivatives
title_sort synthesis, in vitro antimicrobial and cytotoxic activities of some new pyrazolo[1,5-a]pyrimidine derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471749/
https://www.ncbi.nlm.nih.gov/pubmed/30893820
http://dx.doi.org/10.3390/molecules24061080
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