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Role of Natural Products in Modulating Histone Deacetylases in Cancer

Histone deacetylases (HDACs) are enzymes that can control transcription by modifying chromatin conformation, molecular interactions between the DNA and the proteins as well as the histone tail, through the catalysis of the acetyl functional sites removal of proteins from the lysine residues. Also, H...

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Autores principales: Merarchi, Myriam, Sethi, Gautam, Shanmugam, Muthu K., Fan, Lu, Arfuso, Frank, Ahn, Kwang Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471757/
https://www.ncbi.nlm.nih.gov/pubmed/30884859
http://dx.doi.org/10.3390/molecules24061047
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author Merarchi, Myriam
Sethi, Gautam
Shanmugam, Muthu K.
Fan, Lu
Arfuso, Frank
Ahn, Kwang Seok
author_facet Merarchi, Myriam
Sethi, Gautam
Shanmugam, Muthu K.
Fan, Lu
Arfuso, Frank
Ahn, Kwang Seok
author_sort Merarchi, Myriam
collection PubMed
description Histone deacetylases (HDACs) are enzymes that can control transcription by modifying chromatin conformation, molecular interactions between the DNA and the proteins as well as the histone tail, through the catalysis of the acetyl functional sites removal of proteins from the lysine residues. Also, HDACs have been implicated in the post transcriptional process through the regulation of the proteins acetylation, and it has been found that HDAC inhibitors (HDACi) constitute a promising class of pharmacological drugs to treat various chronic diseases, including cancer. Indeed, it has been demonstrated that in several cancers, elevated HDAC enzyme activities may be associated with aberrant proliferation, survival and metastasis. Hence, the discovery and development of novel HDACi from natural products, which are known to affect the activation of various oncogenic molecules, has attracted significant attention over the last decade. This review will briefly emphasize the potential of natural products in modifying HDAC activity and thereby attenuating initiation, progression and promotion of tumors.
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spelling pubmed-64717572019-04-26 Role of Natural Products in Modulating Histone Deacetylases in Cancer Merarchi, Myriam Sethi, Gautam Shanmugam, Muthu K. Fan, Lu Arfuso, Frank Ahn, Kwang Seok Molecules Review Histone deacetylases (HDACs) are enzymes that can control transcription by modifying chromatin conformation, molecular interactions between the DNA and the proteins as well as the histone tail, through the catalysis of the acetyl functional sites removal of proteins from the lysine residues. Also, HDACs have been implicated in the post transcriptional process through the regulation of the proteins acetylation, and it has been found that HDAC inhibitors (HDACi) constitute a promising class of pharmacological drugs to treat various chronic diseases, including cancer. Indeed, it has been demonstrated that in several cancers, elevated HDAC enzyme activities may be associated with aberrant proliferation, survival and metastasis. Hence, the discovery and development of novel HDACi from natural products, which are known to affect the activation of various oncogenic molecules, has attracted significant attention over the last decade. This review will briefly emphasize the potential of natural products in modifying HDAC activity and thereby attenuating initiation, progression and promotion of tumors. MDPI 2019-03-16 /pmc/articles/PMC6471757/ /pubmed/30884859 http://dx.doi.org/10.3390/molecules24061047 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Merarchi, Myriam
Sethi, Gautam
Shanmugam, Muthu K.
Fan, Lu
Arfuso, Frank
Ahn, Kwang Seok
Role of Natural Products in Modulating Histone Deacetylases in Cancer
title Role of Natural Products in Modulating Histone Deacetylases in Cancer
title_full Role of Natural Products in Modulating Histone Deacetylases in Cancer
title_fullStr Role of Natural Products in Modulating Histone Deacetylases in Cancer
title_full_unstemmed Role of Natural Products in Modulating Histone Deacetylases in Cancer
title_short Role of Natural Products in Modulating Histone Deacetylases in Cancer
title_sort role of natural products in modulating histone deacetylases in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471757/
https://www.ncbi.nlm.nih.gov/pubmed/30884859
http://dx.doi.org/10.3390/molecules24061047
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