Cytochrome P450 2D6 profiles and their relationship with outcomes of primaquine anti-relapse therapy in Australian Defence Force personnel deployed to Papua New Guinea and East Timor

BACKGROUND: Primaquine, an 8-aminoquinoline with anti-hypnozoite activity against Plasmodium vivax, is metabolized by human cytochrome P450 2D6 (CYP2D6) to its active metabolite. Human CYP2D6 activities may influence the metabolism of primaquine and the risk of experiencing Plasmodium relapses follo...

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Detalles Bibliográficos
Autores principales: Chen, Nanhua, Dowd, Simone, Gatton, Michelle L., Auliff, Alyson, Edstein, Michael D., Cheng, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471761/
https://www.ncbi.nlm.nih.gov/pubmed/30999967
http://dx.doi.org/10.1186/s12936-019-2774-2

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