Cargando…

Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer’s Disease

Alzheimer’s Disease affects approximately 33 million people worldwide and is characterized by progressive loss of memory at the cognitive level. The formation of toxic amyloid oligomers, extracellular amyloid plaques and amyloid angiopathy in brain by amyloid beta peptides are considered a part of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Ştefănescu, Raluca, Stanciu, Gabriela Dumitriṭa, Luca, Andrei, Caba, Ioana Cezara, Tamba, Bogdan Ionel, Mihai, Cosmin Teodor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471768/
https://www.ncbi.nlm.nih.gov/pubmed/30909659
http://dx.doi.org/10.3390/molecules24061167
_version_ 1783412100176019456
author Ştefănescu, Raluca
Stanciu, Gabriela Dumitriṭa
Luca, Andrei
Caba, Ioana Cezara
Tamba, Bogdan Ionel
Mihai, Cosmin Teodor
author_facet Ştefănescu, Raluca
Stanciu, Gabriela Dumitriṭa
Luca, Andrei
Caba, Ioana Cezara
Tamba, Bogdan Ionel
Mihai, Cosmin Teodor
author_sort Ştefănescu, Raluca
collection PubMed
description Alzheimer’s Disease affects approximately 33 million people worldwide and is characterized by progressive loss of memory at the cognitive level. The formation of toxic amyloid oligomers, extracellular amyloid plaques and amyloid angiopathy in brain by amyloid beta peptides are considered a part of the identified mechanism involved in disease pathogenesis. The optimal treatment approach leads toward finding a chemical compound able to form a noncovalent complex with the amyloid peptide thus blocking the process of amyloid aggregation. This direction gained an increasing interest lately, many studies demonstrating that mass spectrometry is a valuable method useful for the identification and characterization of such molecules able to interact with amyloid peptides. In the present review we aim to identify in the scientific literature low molecular weight chemical compounds for which there is mass spectrometric evidence of noncovalent complex formation with amyloid peptides and also there are toxicity reduction results which verify the effects of these compounds on amyloid beta toxicity towards cell cultures and transgenic mouse models developing Alzheimer’s Disease.
format Online
Article
Text
id pubmed-6471768
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-64717682019-04-26 Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer’s Disease Ştefănescu, Raluca Stanciu, Gabriela Dumitriṭa Luca, Andrei Caba, Ioana Cezara Tamba, Bogdan Ionel Mihai, Cosmin Teodor Molecules Review Alzheimer’s Disease affects approximately 33 million people worldwide and is characterized by progressive loss of memory at the cognitive level. The formation of toxic amyloid oligomers, extracellular amyloid plaques and amyloid angiopathy in brain by amyloid beta peptides are considered a part of the identified mechanism involved in disease pathogenesis. The optimal treatment approach leads toward finding a chemical compound able to form a noncovalent complex with the amyloid peptide thus blocking the process of amyloid aggregation. This direction gained an increasing interest lately, many studies demonstrating that mass spectrometry is a valuable method useful for the identification and characterization of such molecules able to interact with amyloid peptides. In the present review we aim to identify in the scientific literature low molecular weight chemical compounds for which there is mass spectrometric evidence of noncovalent complex formation with amyloid peptides and also there are toxicity reduction results which verify the effects of these compounds on amyloid beta toxicity towards cell cultures and transgenic mouse models developing Alzheimer’s Disease. MDPI 2019-03-24 /pmc/articles/PMC6471768/ /pubmed/30909659 http://dx.doi.org/10.3390/molecules24061167 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ştefănescu, Raluca
Stanciu, Gabriela Dumitriṭa
Luca, Andrei
Caba, Ioana Cezara
Tamba, Bogdan Ionel
Mihai, Cosmin Teodor
Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer’s Disease
title Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer’s Disease
title_full Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer’s Disease
title_fullStr Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer’s Disease
title_full_unstemmed Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer’s Disease
title_short Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer’s Disease
title_sort contributions of mass spectrometry to the identification of low molecular weight molecules able to reduce the toxicity of amyloid-β peptide to cell cultures and transgenic mouse models of alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471768/
https://www.ncbi.nlm.nih.gov/pubmed/30909659
http://dx.doi.org/10.3390/molecules24061167
work_keys_str_mv AT stefanescuraluca contributionsofmassspectrometrytotheidentificationoflowmolecularweightmoleculesabletoreducethetoxicityofamyloidbpeptidetocellculturesandtransgenicmousemodelsofalzheimersdisease
AT stanciugabrieladumitrita contributionsofmassspectrometrytotheidentificationoflowmolecularweightmoleculesabletoreducethetoxicityofamyloidbpeptidetocellculturesandtransgenicmousemodelsofalzheimersdisease
AT lucaandrei contributionsofmassspectrometrytotheidentificationoflowmolecularweightmoleculesabletoreducethetoxicityofamyloidbpeptidetocellculturesandtransgenicmousemodelsofalzheimersdisease
AT cabaioanacezara contributionsofmassspectrometrytotheidentificationoflowmolecularweightmoleculesabletoreducethetoxicityofamyloidbpeptidetocellculturesandtransgenicmousemodelsofalzheimersdisease
AT tambabogdanionel contributionsofmassspectrometrytotheidentificationoflowmolecularweightmoleculesabletoreducethetoxicityofamyloidbpeptidetocellculturesandtransgenicmousemodelsofalzheimersdisease
AT mihaicosminteodor contributionsofmassspectrometrytotheidentificationoflowmolecularweightmoleculesabletoreducethetoxicityofamyloidbpeptidetocellculturesandtransgenicmousemodelsofalzheimersdisease