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Antigen Targets for the Development of Immunotherapies in Leukemia

Immunotherapeutic approaches, including allogeneic stem cell transplantation and donor lymphocyte infusion, have significantly improved the prognosis of leukemia patients. Further efforts are now focusing on the development of immunotherapies that are able to target leukemic cells more specifically,...

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Autores principales: Bauer, Jens, Nelde, Annika, Bilich, Tatjana, Walz, Juliane S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471800/
https://www.ncbi.nlm.nih.gov/pubmed/30897713
http://dx.doi.org/10.3390/ijms20061397
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author Bauer, Jens
Nelde, Annika
Bilich, Tatjana
Walz, Juliane S.
author_facet Bauer, Jens
Nelde, Annika
Bilich, Tatjana
Walz, Juliane S.
author_sort Bauer, Jens
collection PubMed
description Immunotherapeutic approaches, including allogeneic stem cell transplantation and donor lymphocyte infusion, have significantly improved the prognosis of leukemia patients. Further efforts are now focusing on the development of immunotherapies that are able to target leukemic cells more specifically, comprising monoclonal antibodies, chimeric antigen receptor (CAR) T cells, and dendritic cell- or peptide-based vaccination strategies. One main prerequisite for such antigen-specific approaches is the selection of suitable target structures on leukemic cells. In general, the targets for anti-cancer immunotherapies can be divided into two groups: (1) T-cell epitopes relying on the presentation of peptides via human leukocyte antigen (HLA) molecules and (2) surface structures, which are HLA-independently expressed on cancer cells. This review discusses the most promising tumor antigens as well as the underlying discovery and selection strategies for the development of anti-leukemia immunotherapies.
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spelling pubmed-64718002019-04-26 Antigen Targets for the Development of Immunotherapies in Leukemia Bauer, Jens Nelde, Annika Bilich, Tatjana Walz, Juliane S. Int J Mol Sci Review Immunotherapeutic approaches, including allogeneic stem cell transplantation and donor lymphocyte infusion, have significantly improved the prognosis of leukemia patients. Further efforts are now focusing on the development of immunotherapies that are able to target leukemic cells more specifically, comprising monoclonal antibodies, chimeric antigen receptor (CAR) T cells, and dendritic cell- or peptide-based vaccination strategies. One main prerequisite for such antigen-specific approaches is the selection of suitable target structures on leukemic cells. In general, the targets for anti-cancer immunotherapies can be divided into two groups: (1) T-cell epitopes relying on the presentation of peptides via human leukocyte antigen (HLA) molecules and (2) surface structures, which are HLA-independently expressed on cancer cells. This review discusses the most promising tumor antigens as well as the underlying discovery and selection strategies for the development of anti-leukemia immunotherapies. MDPI 2019-03-20 /pmc/articles/PMC6471800/ /pubmed/30897713 http://dx.doi.org/10.3390/ijms20061397 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bauer, Jens
Nelde, Annika
Bilich, Tatjana
Walz, Juliane S.
Antigen Targets for the Development of Immunotherapies in Leukemia
title Antigen Targets for the Development of Immunotherapies in Leukemia
title_full Antigen Targets for the Development of Immunotherapies in Leukemia
title_fullStr Antigen Targets for the Development of Immunotherapies in Leukemia
title_full_unstemmed Antigen Targets for the Development of Immunotherapies in Leukemia
title_short Antigen Targets for the Development of Immunotherapies in Leukemia
title_sort antigen targets for the development of immunotherapies in leukemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471800/
https://www.ncbi.nlm.nih.gov/pubmed/30897713
http://dx.doi.org/10.3390/ijms20061397
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