Cargando…
Antigen Targets for the Development of Immunotherapies in Leukemia
Immunotherapeutic approaches, including allogeneic stem cell transplantation and donor lymphocyte infusion, have significantly improved the prognosis of leukemia patients. Further efforts are now focusing on the development of immunotherapies that are able to target leukemic cells more specifically,...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471800/ https://www.ncbi.nlm.nih.gov/pubmed/30897713 http://dx.doi.org/10.3390/ijms20061397 |
_version_ | 1783412107599937536 |
---|---|
author | Bauer, Jens Nelde, Annika Bilich, Tatjana Walz, Juliane S. |
author_facet | Bauer, Jens Nelde, Annika Bilich, Tatjana Walz, Juliane S. |
author_sort | Bauer, Jens |
collection | PubMed |
description | Immunotherapeutic approaches, including allogeneic stem cell transplantation and donor lymphocyte infusion, have significantly improved the prognosis of leukemia patients. Further efforts are now focusing on the development of immunotherapies that are able to target leukemic cells more specifically, comprising monoclonal antibodies, chimeric antigen receptor (CAR) T cells, and dendritic cell- or peptide-based vaccination strategies. One main prerequisite for such antigen-specific approaches is the selection of suitable target structures on leukemic cells. In general, the targets for anti-cancer immunotherapies can be divided into two groups: (1) T-cell epitopes relying on the presentation of peptides via human leukocyte antigen (HLA) molecules and (2) surface structures, which are HLA-independently expressed on cancer cells. This review discusses the most promising tumor antigens as well as the underlying discovery and selection strategies for the development of anti-leukemia immunotherapies. |
format | Online Article Text |
id | pubmed-6471800 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64718002019-04-26 Antigen Targets for the Development of Immunotherapies in Leukemia Bauer, Jens Nelde, Annika Bilich, Tatjana Walz, Juliane S. Int J Mol Sci Review Immunotherapeutic approaches, including allogeneic stem cell transplantation and donor lymphocyte infusion, have significantly improved the prognosis of leukemia patients. Further efforts are now focusing on the development of immunotherapies that are able to target leukemic cells more specifically, comprising monoclonal antibodies, chimeric antigen receptor (CAR) T cells, and dendritic cell- or peptide-based vaccination strategies. One main prerequisite for such antigen-specific approaches is the selection of suitable target structures on leukemic cells. In general, the targets for anti-cancer immunotherapies can be divided into two groups: (1) T-cell epitopes relying on the presentation of peptides via human leukocyte antigen (HLA) molecules and (2) surface structures, which are HLA-independently expressed on cancer cells. This review discusses the most promising tumor antigens as well as the underlying discovery and selection strategies for the development of anti-leukemia immunotherapies. MDPI 2019-03-20 /pmc/articles/PMC6471800/ /pubmed/30897713 http://dx.doi.org/10.3390/ijms20061397 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bauer, Jens Nelde, Annika Bilich, Tatjana Walz, Juliane S. Antigen Targets for the Development of Immunotherapies in Leukemia |
title | Antigen Targets for the Development of Immunotherapies in Leukemia |
title_full | Antigen Targets for the Development of Immunotherapies in Leukemia |
title_fullStr | Antigen Targets for the Development of Immunotherapies in Leukemia |
title_full_unstemmed | Antigen Targets for the Development of Immunotherapies in Leukemia |
title_short | Antigen Targets for the Development of Immunotherapies in Leukemia |
title_sort | antigen targets for the development of immunotherapies in leukemia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471800/ https://www.ncbi.nlm.nih.gov/pubmed/30897713 http://dx.doi.org/10.3390/ijms20061397 |
work_keys_str_mv | AT bauerjens antigentargetsforthedevelopmentofimmunotherapiesinleukemia AT neldeannika antigentargetsforthedevelopmentofimmunotherapiesinleukemia AT bilichtatjana antigentargetsforthedevelopmentofimmunotherapiesinleukemia AT walzjulianes antigentargetsforthedevelopmentofimmunotherapiesinleukemia |